2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

Product Name: 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
CAS No.: 1675201-83-8
Chemical Name: 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
Synonyms: BMS-1;T3655;CS-2413;avelumab/PD-L1;PD-1PD-L1 inhibitor;PD1-PDL1 inhibitor 1;PD-1/PD-L1 inhibitor 1(C1);BMS-1 (PD-1/PD-L1 inhibitor 1);PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1);PD-1/PD-L1 inhibitor Impurity 8 (BMS 1)
CBNumber: CB23049190
Molecular Formula: C29H33NO5
Formula Weight: 475.58
MOL File: 1675201-83-8.mol

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2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Property

Boiling point:: 630.2±55.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
form: solid
pka: 2.34±0.20(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19914
Product name: PD-1/PD-L1 Inhibitor 1
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 19914
Product name: PD-1/PD-L1 Inhibitor 1
Purity: ≥98%
Packaging: 5mg
Price: $112
Updated: 2024/03/01

Cayman Chemical

Product number: 19914
Product name: PD-1/PD-L1 Inhibitor 1
Purity: ≥98%
Packaging: 10mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 19914
Product name: PD-1/PD-L1 Inhibitor 1
Purity: ≥98%
Packaging: 25mg
Price: $384
Updated: 2024/03/01

ApexBio Technology

Product number: B6172
Product name: PD-1/PD-L1inhibitor1
Packaging: 5mg
Price: $103
Updated: 2021/12/16

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2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Chemical Properties,Usage,Production

Description

PD-1/PD-L1 Inhibitor 1 (1675201-83-8) inhibits (IC50 = <100nM) the formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1

Uses

BMS-1 is a PD-L1 inhibitor which is used in combination with LIF inhibitors for the treatment of cancers.

in vitro

pd-1/pd-l1 inhibitor 1 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (pd-1) with its ligand protein (pd-l1). pd-1/pd-l1 inhibitor 1 was also found to act as an immunomodulator. in preclinical studies, pd-1/pd-l1 inhibitor 1 was able to block pd-1/pd-ll interactions with an ic50 value between 6 and 100 nm, which was measured by a homogenous time-resolved fluorescence (htrf) binding assay. thus, pd-1/pd-l1 inhibitor 1 might potentially be used for the treatment of cancer as well as infectious diseases, such as hepatitis c [1].

IC 50

0.006-0.10 μm

References

1) Chupak?et al. (2015), Compounds Useful as Immunomodulators; WO2015/034820

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Suppliers

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View Lastest Price from 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- manufacturers

Career Henan Chemical Co

Product: 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- 1675201-83-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-18

1675201-83-8, 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-Related Search:

ZM 447439 AAL-993 Brefeldin A SU 4312 BMS-986020 BMS-852927 XL-652 BMS-986142 BMS 303141 BMS813160 Insulin-like Growth Factor-1 Receptor Inhibitor PD-L1 inhibitor 1 AC480 (BMS-599626) BMS-986205 3-chloro-2-(1,1-difluorobut-3-enyl)-6-methoxyquinoxaline GSK591

T3655

(2S)-1-{2,6-Dimethoxy-4-[(2-methyl-3-biphenylyl)methoxy]benzyl}-2-piperidinecarboxylic acid

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

PD1-PDL1 inhibitor 1

PD-1PD-L1 inhibitor

(2S)-1-[[2,6-Dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid

avelumab/PD-L1

PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1)

BMS-1

BMS-1 (PD-1/PD-L1 inhibitor 1)

CS-2413

PD1/PDL1 INHIBITOR 1;PD 1/PD L1 INHIBITOR 1

PD-1/PD-L1 inhibitor 1(C1)

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

(S)-1-(2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid

PD-1/PD-L1 inhibitor Impurity 8 (BMS 1)

PD-1/PD-L1 inhibitor 1, small molecule inhibitor

1675201-83-8