2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
- Product Name
- 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
- CAS No.
- 1675201-83-8
- Chemical Name
- 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
- Synonyms
- BMS-1;T3655;CS-2413;avelumab/PD-L1;PD-1PD-L1 inhibitor;PD1-PDL1 inhibitor 1;PD-1/PD-L1 inhibitor 1(C1);BMS-1 (PD-1/PD-L1 inhibitor 1);PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1);PD-1/PD-L1 inhibitor Impurity 8 (BMS 1)
- CBNumber
- CB23049190
- Molecular Formula
- C29H33NO5
- Formula Weight
- 475.58
- MOL File
- 1675201-83-8.mol
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Property
- Boiling point:
- 630.2±55.0 °C(Predicted)
- Density
- 1.182±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
- form
- solid
- pka
- 2.34±0.20(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19914
- Product name
- PD-1/PD-L1 Inhibitor 1
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 19914
- Product name
- PD-1/PD-L1 Inhibitor 1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $112
- Updated
- 2024/03/01
- Product number
- 19914
- Product name
- PD-1/PD-L1 Inhibitor 1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $207
- Updated
- 2024/03/01
- Product number
- 19914
- Product name
- PD-1/PD-L1 Inhibitor 1
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- CS-5545
- Product name
- BMS-1
- Purity
- 99.61%
- Packaging
- 100mg
- Price
- $1056
- Updated
- 2021/12/16
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Chemical Properties,Usage,Production
Description
PD-1/PD-L1 Inhibitor 1 (1675201-83-8) inhibits (IC50 = <100nM) the formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1
Uses
BMS-1 is a PD-L1 inhibitor which is used in combination with LIF inhibitors for the treatment of cancers.
in vitro
pd-1/pd-l1 inhibitor 1 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (pd-1) with its ligand protein (pd-l1). pd-1/pd-l1 inhibitor 1 was also found to act as an immunomodulator. in preclinical studies, pd-1/pd-l1 inhibitor 1 was able to block pd-1/pd-ll interactions with an ic50 value between 6 and 100 nm, which was measured by a homogenous time-resolved fluorescence (htrf) binding assay. thus, pd-1/pd-l1 inhibitor 1 might potentially be used for the treatment of cancer as well as infectious diseases, such as hepatitis c [1].
IC 50
0.006-0.10 μm
References
1) Chupak?et al. (2015), Compounds Useful as Immunomodulators; WO2015/034820
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Preparation Products And Raw materials
Raw materials
Preparation Products
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- Product
- 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- 1675201-83-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-18