Bis-Mal-Lysine-PEG4-TFP ester

Product Name: Bis-Mal-Lysine-PEG4-TFP ester
CAS No.: 1426164-53-5
Chemical Name: Bis-Mal-Lysine-PEG4-TFP ester
Synonyms: Bis-Mal-Lysine-PEG4-TFP ester;Bis-MAL-Lysine-dPEG??-TFP ester (QBD-10631);2,3,5,6-Tetrafluorophenyl (S)-26-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-18-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)-17,24-dioxo-4,7,10,13-tetraoxa-16,23-diazahexacosanoate;4,7,10,13-Tetraoxa-16,23-diazahexacosanoic acid, 26-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-18-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]-17,24-dioxo-, 2,3,5,6-tetrafluorophenyl ester, (18S)-
CBNumber: CB23062405
Molecular Formula: C37H45F4N5O13
Formula Weight: 843.77
MOL File: 1426164-53-5.mol

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Bis-Mal-Lysine-PEG4-TFP ester Property

Boiling point:: 1012.1±65.0 °C(Predicted)
Density: 1.364±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
form: Solid
pka: 14.12±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M198148
Product name: Bis-Mal-Lysine-PEG4-TFPester
Packaging: 1mg
Price: $45
Updated: 2021/12/16

BroadPharm

Product number: BP-22617
Product name: Bis-Mal-Lysine-PEG4-TFPester
Purity: 98%
Packaging: 100mg
Price: $360
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1240
Product name: Bis-Mal-Lysine-PEG4-TFP ester
Packaging: 100mg
Price: $701
Updated: 2021/12/16

BroadPharm

Product number: BP-22617
Product name: Bis-Mal-Lysine-PEG4-TFPester
Purity: 98%
Packaging: 500mg
Price: $1100
Updated: 2021/12/16

BroadPharm

Product number: BP-22617
Product name: Bis-Mal-Lysine-PEG4-TFPester
Purity: 98%
Packaging: 1g
Price: $1650
Updated: 2021/12/16

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Bis-Mal-Lysine-PEG4-TFP ester Chemical Properties,Usage,Production

Description

Bis-Mal-Lysine-PEG4-TFP ester contains two malimide end groups which can react with thiol groups from pH 6.5 to 7.5 to form thiolester bonds. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG linker increases the compound's water solubility in aqueous environments.

Uses

Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bis-Mal-Lysine-PEG4-TFP ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bis-Mal-Lysine-PEG4-TFP ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Bis-Mal-Lysine-PEG4-TFP ester 1426164-53-5
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-03-27

1426164-53-5, Bis-Mal-Lysine-PEG4-TFP esterRelated Search:

alpha, oMega-DisucciniMidyl hexaethylene glycol alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) Mal-PEG2-amine Mal-PEG3-NHS ester Mal-PEG6-COOH N-Succinimidyl 3-maleimidopropionate Mal-PEG4-NHS ester 3,4-Dibromo-Mal-PEG2-Amine Maleimido-Tri(Ethylene Glycol)-Propionic Acid Mal-PEG2-COOH N-[4-(-Carboxycyclohexylmethyl)]maleimide Mal-PEG4-Acid Mal-PEG2-NHS ester Maleimide-PEG4-NHS Ester Maleimide-PEG2-NHS Ester 3-Maleimidopropionic acid Mal-PEG2-acid Mal-Amido-PEG4-acid

Bis-Mal-Lysine-PEG4-TFP ester

4,7,10,13-Tetraoxa-16,23-diazahexacosanoic acid, 26-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-18-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]-17,24-dioxo-, 2,3,5,6-tetrafluorophenyl ester, (18S)-

Bis-MAL-Lysine-dPEG??-TFP ester (QBD-10631)

2,3,5,6-Tetrafluorophenyl (S)-26-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-18-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)-17,24-dioxo-4,7,10,13-tetraoxa-16,23-diazahexacosanoate

1426164-53-5

C37H45F4N5O13