ChemicalBook > CAS DataBase List > Tos-PEG5-CH2CO2t-butyl ester

Tos-PEG5-CH2CO2t-butyl ester

Product Name
Tos-PEG5-CH2CO2t-butyl ester
CAS No.
169751-73-9
Chemical Name
Tos-PEG5-CH2CO2t-butyl ester
Synonyms
Tos-PEG4-CH2-Boc;Tos-PEG5-CH2CO2tBu;Tos-PEG4-CH2COOtBu;Tos-PEG4-t-butyl acetate;Tos-PEG5-CH2CO2t-butyl ester;tert-butyl 14-(tosyloxy)-3,6,9,12-tetraoxatetradecanoate;2-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-;tert-Butyl 14-(tosyloxy)-3,6,9,12-tetraoxatetradecan-1-oate;tert-butyl 2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]acetate;2-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
CBNumber
CB23062692
Molecular Formula
C21H34O9S
Formula Weight
462.55
MOL File
169751-73-9.mol
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Tos-PEG5-CH2CO2t-butyl ester Property

Boiling point:
550.0±50.0 °C(Predicted)
Density 
1.163±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific
Product number
AS104010
Product name
Tos-PEG4-CH2COOtBu
Purity
95+%
Packaging
250mg
Price
$256
Updated
2021/12/16
Activate Scientific
Product number
AS104010
Product name
Tos-PEG4-CH2COOtBu
Purity
95+%
Packaging
1g
Price
$583
Updated
2021/12/16
BroadPharm
Product number
BP-22123
Product name
Tos-PEG5-CH2CO2tBu
Purity
98%
Packaging
500mg
Price
$620
Updated
2021/12/16
Apolloscientific
Product number
BIPG1860
Product name
Tos-PEG5-CH2CO2t-butyl ester
Packaging
250mg
Price
$701
Updated
2021/12/16
Matrix Scientific
Product number
179756
Product name
[2-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
Purity
95%
Packaging
1g
Price
$1073
Updated
2021/12/16
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Tos-PEG5-CH2CO2t-butyl ester Chemical Properties,Usage,Production

Description

Tos-PEG5-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tos-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6

Tos-PEG5-CH2CO2t-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Tos-PEG5-CH2CO2t-butyl ester Suppliers

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169751-73-9, Tos-PEG5-CH2CO2t-butyl esterRelated Search:

Tos-PEG2-t-butyl ester Tos-PEG4-CH2CO2H Tos-PEG4-t-butyl ester Tos-PEG6-t-Butyl ester Tos-PEG3-CH2CO2tBu Tos-PEG9-t-butyl ester Tos-PEG7-t-butyl ester Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) Tos-PEG21-Tos Tri(Ethylene Glycol) DI-P-Toluenesulfonate TETRAETHYLENE GLYCOL DI-P-TOSYLATE Tos-PEG13-t-butyl ester TOS-PEG5-THP Tos-PEG5 t-butyl ester Tos-PEG10-CH2CH2COOtBu Tos-PEG3-t-butyl ester Tos-PEG13-Tos (2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid tert-butyl ester

  • Tos-PEG5-CH2CO2t-butyl ester
  • Tos-PEG4-CH2COOtBu
  • Tos-PEG5-CH2CO2tBu
  • Tos-PEG4-CH2-Boc
  • 3,6,9,12-Tetraoxatetradecanoic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
  • tert-butyl 2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]acetate
  • 2-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
  • Tos-PEG4-t-butyl acetate
  • tert-Butyl 14-(tosyloxy)-3,6,9,12-tetraoxatetradecan-1-oate
  • 2-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-
  • Tos-PEG4-CH2COOtBu/3,6,9,12-Tetraoxatetradecanoic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
  • tert-butyl 14-(tosyloxy)-3,6,9,12-tetraoxatetradecanoate
  • 169751-73-9
  • C21H34O9S