Tos-PEG4-t-butyl ester

Product Name: Tos-PEG4-t-butyl ester
CAS No.: 217817-01-1
Chemical Name: Tos-PEG4-t-butyl ester
Synonyms: Tos-PEG4-Boc;Tos-PEG3-COOtBu;Tos-PEG3-CH2CH2COOtBu;Tos-PEG4-t-butyl ester;Tos-PEG4-t-butyl ester (Tos-PEG4-Boc);tert-butyl 3-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)propanoate;tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate;tert-butyl 3-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]propanoate;3-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester;Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester
CBNumber: CB63062690
Molecular Formula: C20H32O8S
Formula Weight: 432.53
MOL File: 217817-01-1.mol

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Tos-PEG4-t-butyl ester Property

Boiling point:: 528.5±45.0 °C(Predicted)
Density: 1.154±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-20636
Product name: Tos-PEG4-t-butylester
Purity: 98%
Packaging: 250mg
Price: $220
Updated: 2021/12/16

Activate Scientific

Product number: AS104012
Product name: Tos-PEG3-CH2CH2COOtBu
Purity: 95+%
Packaging: 1g
Price: $421
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1863
Product name: Tos-PEG4-t-butyl ester
Packaging: 250mg
Price: $428
Updated: 2021/12/16

BroadPharm

Product number: BP-20636
Product name: Tos-PEG4-t-butylester
Purity: 98%
Packaging: 1g
Price: $450
Updated: 2021/12/16

Matrix Scientific

Product number: 179768
Product name: 3-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester
Purity: 95%
Packaging: 1g
Price: $660
Updated: 2021/12/16

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Tos-PEG4-t-butyl ester Chemical Properties,Usage,Production

Description

Tos-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].

IC 50

PEGs; Alkyl/ether

References

[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826

Tos-PEG4-t-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Tos-PEG4-t-butyl ester Suppliers

China 52 India 1 United Kingdom 1 United States 5 Global 59

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Nanjing Junnahe Biopharmaceutical Co., Ltd

Tel: 025-58367986 17351780683
Fax: QQ3209878052
Email: amy.xiang@ally-chem.com
Country: China
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Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Nanjing Ally Chemical S&T Co., Ltd.

Tel: 025-025-58367986 18913956109
Fax: QQ:3209878052
Email: amy.xiang@ally-chem.com
Country: China
ProdList: 567
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Jinan elephant international trading co., LTD

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Country: China
ProdList: 6355
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Shanghai Yihe Biological Technology Co., Ltd.

Tel: 021-68882955 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 4991
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Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
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Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
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Henan Alfachem Co.,Ltd.

Tel: 0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9999
Advantage: 58

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View Lastest Price from Tos-PEG4-t-butyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Tos-PEG4-COOtBu 217817-01-1
Price: US $0.00/g
Min. Order: 5g
Purity: >98.00%
Supply Ability: 5g
Release date: 2024-03-27

217817-01-1, Tos-PEG4-t-butyl esterRelated Search:

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tert-butyl 3-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]propanoate

Tos-PEG4-t-butyl ester

Tos-PEG3-CH2CH2COOtBu

Tos-PEG4-Boc

Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester

Tos-PEG3-COOtBu

3-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc)

tert-butyl 3-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)propanoate

Tos-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester

217817-01-1