ChemicalBook > CAS DataBase List > Tos-PEG4-t-butyl ester

Tos-PEG4-t-butyl ester

Product Name
Tos-PEG4-t-butyl ester
CAS No.
217817-01-1
Chemical Name
Tos-PEG4-t-butyl ester
Synonyms
Tos-PEG4-Boc;Tos-PEG3-COOtBu;Tos-PEG3-CH2CH2COOtBu;Tos-PEG4-t-butyl ester;Tos-PEG4-t-butyl ester (Tos-PEG4-Boc);tert-butyl 3-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)propanoate;tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate;tert-butyl 3-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]propanoate;3-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester;Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester
CBNumber
CB63062690
Molecular Formula
C20H32O8S
Formula Weight
432.53
MOL File
217817-01-1.mol
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Tos-PEG4-t-butyl ester Property

Boiling point:
528.5±45.0 °C(Predicted)
Density 
1.154±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-20636
Product name
Tos-PEG4-t-butylester
Purity
98%
Packaging
250mg
Price
$220
Updated
2021/12/16
Activate Scientific
Product number
AS104012
Product name
Tos-PEG3-CH2CH2COOtBu
Purity
95+%
Packaging
1g
Price
$421
Updated
2021/12/16
Apolloscientific
Product number
BIPG1863
Product name
Tos-PEG4-t-butyl ester
Packaging
250mg
Price
$428
Updated
2021/12/16
BroadPharm
Product number
BP-20636
Product name
Tos-PEG4-t-butylester
Purity
98%
Packaging
1g
Price
$450
Updated
2021/12/16
Matrix Scientific
Product number
179768
Product name
3-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester
Purity
95%
Packaging
1g
Price
$660
Updated
2021/12/16
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Tos-PEG4-t-butyl ester Chemical Properties,Usage,Production

Description

Tos-PEG4-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].

IC 50

PEGs; Alkyl/ether

References

[1] Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520. DOI:10.1021/acs.jmedchem.8b01826

Tos-PEG4-t-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tos-PEG4-t-butyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Tos-PEG4-COOtBu 217817-01-1
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-27

217817-01-1, Tos-PEG4-t-butyl esterRelated Search:

Tos-PEG3-t-butyl ester Tos-PEG2-t-butyl ester Tos-PEG4-CH2CO2H Tos-PEG6-t-Butyl ester Tos-PEG3-CH2CO2tBu Tos-PEG5-CH2CO2H Tos-PEG5-CH2CO2t-butyl ester Tos-PEG5 t-butyl ester Tos-PEG9-t-butyl ester Tos-PEG7-t-butyl ester Tos-PEG10-CH2CH2COOtBu Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) Tos-PEG1-COOtBu Tos-PEG8-COOtBu TOS-PEG5-THP Tos-PEG13-t-butyl ester TETRAETHYLENE GLYCOL DI-P-TOSYLATE Tri(Ethylene Glycol) DI-P-Toluenesulfonate

  • tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate
  • tert-butyl 3-[2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethoxy]propanoate
  • Tos-PEG4-t-butyl ester
  • Tos-PEG3-CH2CH2COOtBu
  • Tos-PEG4-Boc
  • Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester
  • Tos-PEG3-COOtBu
  • 3-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid tert-butyl ester
  • Tos-PEG4-t-butyl ester (Tos-PEG4-Boc)
  • tert-butyl 3-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)propanoate
  • Tos-PEG3-CH2CH2COOtBu/Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester
  • 217817-01-1