Verbascoside

Description Natural occurrences Mechanism of action

Product Name: Verbascoside
CAS No.: 61276-17-3
Chemical Name: Verbascoside
Synonyms: ACTEOSIDE;ISOVERBASCOSIDE;Acetoside;KUSAGININ;Kusagi;TJC 160;NSC 603831;Russetinol;Verbacoside;VERBASCOSIDE
CBNumber: CB2306760
Molecular Formula: C29H36O15
Formula Weight: 624.59
MOL File: 61276-17-3.mol

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Verbascoside Property

Melting point:: 232℃
Boiling point:: 908.8±65.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Ethyl Acetate (Very Slightly), Methanol (Slightly)
pka: 9.31±0.10(Predicted)
form: Solid
color: White to Pale Yellow
Stability:: Hygroscopic
InChIKey: FBSKJMQYURKNSU-ZLSOWSIRSA-N
LogP: 0.077 (est)
CAS DataBase Reference: 61276-17-3(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 2
RTECS: LZ5786000
HS Code: 29389090
Toxicity: LD50 oral in rat: > 5gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1711455
Product name: Verbascoside
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $539
Updated: 2024/03/01

Sigma-Aldrich

Product number: 00820580
Product name: Verbascoside
Purity: primary pharmaceutical reference standard
Packaging: 10mg
Price: $570
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89289
Product name: Verbascoside
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $435
Updated: 2023/01/07

TCI Chemical

Product number: V0153
Product name: Verbascoside
Purity: >97.0%(HPLC)
Packaging: 10mg
Price: $141
Updated: 2024/03/01

TCI Chemical

Product number: V0153
Product name: Verbascoside
Purity: >97.0%(HPLC)
Packaging: 50mg
Price: $494
Updated: 2024/03/01

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Verbascoside Chemical Properties,Usage,Production

Description

Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

Natural occurrences

Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.

Mechanism of action

It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.

Chemical Properties

White solid

Uses

Verbascoside is an agent producing effects on anti-GBM nephritis in rats. Effective agent against glomerulonephritis. Phenolic anti-oxidant agent.

Definition

ChEBI: Acteoside is a glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid. It has a role as a neuroprotective agent, an antileishmanial agent, an anti-inflammatory agent, a plant metabolite and an antibacterial agent. It is a cinnamate ester, a disaccharide derivative, a member of catechols, a polyphenol and a glycoside. It is functionally related to a hydroxytyrosol and a trans-caffeic acid.

Enzyme inhibitor

This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.

Verbascoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Verbascoside Suppliers

China 260 France 2 Germany 5 India 3 Japan 1 United Kingdom 7 United States 29 USA 1 Global 308

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View Lastest Price from Verbascoside manufacturers

Sinoway Industrial co., ltd.

Product: Desertliving Cistanche Extract 61276-17-3
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: Echinacoside 80%
Supply Ability: 20 tons
Release date: 2021-07-28

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: 3,4-Dihydroxyphenethyl alcohol acteoside 61276-17-3
Price: US $31.88/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-27

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: VERBASCOSIDE WITH HPLC 61276-17-3
Price: US $31.87/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-27

61276-17-3, VerbascosideRelated Search:

Nicergoline CHLOROPHOSPHONAZO III Alkyl polyglucoside Cabergoline 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL STEVIA Dihydroergotoxine mesylate CALYCOSIN CALYCOSIN 7-O-GLUCOSIDE 6-O-ACETYLACTEOSIDE Forsythoside B CISTANOSIDE C ECHINACOSIDE ergotamine Angoroside C Isoacteoside CAMPNEOSIDE I MARTYNOSIDE

glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos

ACTEOSIDE :B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-A-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-,

Acetoside

Extract from Verbena minutiflora (B864379)

[(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

VERBASCOSIDE WITH HPLC

2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate]

3,4-Dihydroxyphenethyl alcohol acteoside

Verbacoside

Acteoside(Verbascoside)

Distinctive PhytosteM Lilac

Verbascoside ,98%

NSC 603831

Russetinol

StereosperMin

TJC 160

Verbascoside(Acteoside)

Verbascoside, froM Cistanche deserticola Y.C.Ma

VERBASCOSIDE

ISOVERBASCOSIDE

KUSAGININ

B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-

4-(3-(3,4-dihydroxyphenyl)-2-propenoate),(e)-beta-d-yl)

Verbascoside [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

ACTEOSIDE

β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

Nano Liposomal Acteoside

Verbascoside, 98%, from Cistanche deserticola Y.C.Ma

Acteoside Kusaginin 61276-17-3

Kusagi

Acteoside Standard

2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-Deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]-beta-D-glucopyranoside

Verbascoside USP/EP/BP

Cistanche Deserticola Extract Acteoside

(2R,3R,4R,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-5-hydroxy-2-(hydroxymethyl)-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate

Verbascoside (15 mg)

61276-17-3

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

chemical reagent

pharmaceutical intermediate

phytochemical

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