ChemicalBook > CAS DataBase List > 1-(2-Methoxyethyl)piperazine

1-(2-Methoxyethyl)piperazine

Product Name
1-(2-Methoxyethyl)piperazine
CAS No.
13484-40-7
Chemical Name
1-(2-Methoxyethyl)piperazine
Synonyms
gx1011-aM;RARECHEM AH CK 0124;Methoxyethylpiperazine;1-(2-METHOXYETHYL)PIPERAZINE;N-(2-Methoxyethyl)piperazine;4-(2-Methoxyethyl)piperazine;1-N- Methoxyethyl piperazine;1-(2-Methoxyethyl)piperzazine;1-(2-Methoxyethyl)piperazine>Piperazine, 1-(2-methoxyethyl)-
CBNumber
CB2315317
Molecular Formula
C7H16N2O
Formula Weight
144.21
MOL File
13484-40-7.mol
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1-(2-Methoxyethyl)piperazine Property

Melting point:
100-101 °C
Boiling point:
193-194 °C (lit.)
Density 
0.970 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.4730(lit.)
Flash point:
188 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
9.15±0.10(Predicted)
form 
Liquid
color 
Clear colorless to yellow
BRN 
105098
InChIKey
BMEMBBFDTYHTLH-UHFFFAOYSA-N
CAS DataBase Reference
13484-40-7(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-36/37/38
Safety Statements 
26-36/37/39-45-37/39
RIDADR 
UN 2735 8/PG 3
WGK Germany 
3
F 
10-34
Hazard Note 
Irritant
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H227Combustible liquid

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
571423
Product name
1-(2-Methoxyethyl)piperazine
Purity
97%
Packaging
1g
Price
$42.3
Updated
2023/01/07
TCI Chemical
Product number
M2169
Product name
1-(2-Methoxyethyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$81
Updated
2025/07/31
TCI Chemical
Product number
M2169
Product name
1-(2-Methoxyethyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$205
Updated
2025/07/31
TRC
Product number
M304298
Product name
1-(2-Methoxyethyl)piperazine
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
M304298
Product name
1-(2-Methoxyethyl)piperazine
Packaging
1g
Price
$75
Updated
2021/12/16
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1-(2-Methoxyethyl)piperazine Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

Reactant for:• ;Preparation of biologically and pharmacologically active molecules1,2,3,4,5

Uses

Reactant for:

  • Preparation of biologically and pharmacologically active molecules

Synthesis

110-85-0

627-42-9

13484-40-7

13484-41-8

Under nitrogen protection, 8.6 g (0.1 mol) of piperazine and 10.4 g of methanol were added to the reaction flask, 35 µl of hydrochloric acid (10.4 g, 0.1 mol) was added with stirring, and the internal temperature was controlled to 80 °C. Under the condition of keeping the internal temperature below 80 °C, 8.7 g (0.07 mol) of 2-bromoethanol was added slowly and dropwise over 0.5 h. Subsequently, the reaction was continued with stirring at the same temperature for 8 h. 36.9 g of colorless and transparent reaction solution was obtained. Gas chromatographic analysis showed a yield of 84.6% for N-(2-hydroxyethyl)piperazine, with a selectivity of 88.5% for N-(2-hydroxyethyl)piperazine, 7.7% for N,N'-bis(2-hydroxyethyl)piperazine, and 3.8% for the unknown component. Compared to the results of Example 2 in Table 1 , the reaction conditions were the same as in Example 2 when 3.8 g (0.04 mol) of 2-methoxyethyl ester was used in place of 2-bromoethanol. GC analysis showed a 70.1% yield of N-(2-methoxyethyl)piperazine with a selectivity of 83.4% for N-(2-methoxyethyl)piperazine, 15.0% for N,N'-bis(2-methoxyethyl)piperazine, and 1.6% for the unknown component. This result is consistent with the results of Example 5 in Table 1.

References

[1] Patent: JP5838628, 2016, B2. Location in patent: Paragraph 0056; 0059

1-(2-Methoxyethyl)piperazine Preparation Products And Raw materials

Raw materials

1-Bromo-2-methoxyethane Ethanol Sodium sulfate Triethylamine Piperazine Hydrochloric acid Sodium bicarbonate Dichloromethane Sodium hydroxide 1-BOC-Piperazine 2-Methoxyethyl chloride

Preparation Products

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View Lastest Price from 1-(2-Methoxyethyl)piperazine manufacturers

Firsky International Trade (Wuhan) Co., Ltd
Product
1-(2-Methoxyethyl)piperazine 13484-40-7
Price
US $30.00/L
Min. Order
1L
Purity
99%
Supply Ability
20T
Release date
2023-10-08
Honest Joy Holdings Limited
Product
1-(2-Methoxyethyl)piperazine 13484-40-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98.4%
Supply Ability
100 tons
Release date
2022-01-25
Career Henan Chemical Co
Product
1-(2-Methoxyethyl)piperazine 13484-40-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-07-02

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