4-Pyridinecarboxaldehyde
Flavor Type Chemical Properties Uses- Product Name
- 4-Pyridinecarboxaldehyde
- CAS No.
- 872-85-5
- Chemical Name
- 4-Pyridinecarboxaldehyde
- Synonyms
- ISONICOTINALDEHYDE;PYRIDINE-4-CARBALDEHYDE;PYRIDINE-4-CARBOXALDEHYDE;4-PYRIDINECARBALDEHYDE;PYRIDINE-4-ALDEHYDE;4-pyrdine aldehyde;Isonicotinic aldehyde;4-PyridineCarboxyaldehyde;Pyridin-4-al;4-Formylpyrdine
- CBNumber
- CB2315397
- Molecular Formula
- C6H5NO
- Formula Weight
- 107.11
- MOL File
- 872-85-5.mol
4-Pyridinecarboxaldehyde Property
- Melting point:
- -4--2°C
- Boiling point:
- 71-73 °C/10 mmHg (lit.)
- Density
- 1.137 g/mL at 20 °C (lit.)
- vapor pressure
- 0.02 hPa (20 °C)
- refractive index
- n20/D 1.544(lit.)
- Flash point:
- 130 °F
- storage temp.
- Store at +2°C to +8°C.
- solubility
- 20g/l
- pka
- 12.05(at 30℃)
- form
- liquid (clear)
- color
- clear brown-yellow
- PH
- 7-8 (H2O, 20℃)(saturated aqueous solution)
- Water Solubility
- 20 g/L (20 ºC)
- Sensitive
- Air Sensitive
- BRN
- 105342
- InChIKey
- BGUWFUQJCDRPTL-UHFFFAOYSA-N
- LogP
- 0.12 at 30℃ and pH7
- CAS DataBase Reference
- 872-85-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Pyridinecarboxaldehyde(872-85-5)
- EPA Substance Registry System
- 4-Pyridinecarboxaldehyde (872-85-5)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 36/37/38-10
- Safety Statements
- 26-36-36/37/39-16
- RIDADR
- UN 1989
- WGK Germany
- 1
- RTECS
- NR9400000
- F
- 8-10-23
- Hazard Note
- Irritant/Keep Cold/Air Sensitive
- TSCA
- Yes
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29333999
- Toxicity
- LD50 orally in Rabbit: 2355 mg/kg LD50 dermal Rat > 2000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P62402
- Product name
- 4-Pyridinecarboxaldehyde
- Purity
- 97%
- Packaging
- 25g
- Price
- $116
- Updated
- 2025/07/31
- Product number
- P62402
- Product name
- 4-Pyridinecarboxaldehyde
- Purity
- 97%
- Packaging
- 100g
- Price
- $253
- Updated
- 2025/07/31
- Product number
- I0143
- Product name
- 4-Pyridinecarboxaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 25mL
- Price
- $41
- Updated
- 2025/07/31
- Product number
- I0143
- Product name
- 4-Pyridinecarboxaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 500mL
- Price
- $581
- Updated
- 2021/12/16
- Product number
- P62402
- Product name
- 4-Pyridinecarboxaldehyde
- Purity
- 97%
- Packaging
- 500g
- Price
- $328.5
- Updated
- 2025/07/31
4-Pyridinecarboxaldehyde Chemical Properties,Usage,Production
Flavor Type
Flavor Type: fruity
Chemical Properties
4-Pyridinecarboxaldehyde(4PCA) is a slightly yellow oily liquid. Its relative density is 1.122, and its refractive index is 1.5352 (25°C). Flash point is 54 ° C. 4-Pyridinecarboxaldehyde is soluble in water and ether.4-Pyridinecarboxaldehyde, also commonly called pyridine-2-carboxaldehyde, is an organic compound with the formula NC5H4CHO. 4-Pyridinecarboxaldehyde is a colorless oily liquid with a distinctive odor. Older samples are often brown-colored owing to impurities.
Uses
4-Pyridinecarboxaldehyde is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.4-Pyridinecarboxaldehyde and some of its derivatives have also been reported as useful transamination reagents to introduce ketone or aldehyde groups onto the N-termini of antibodies for subsequent site-specifically conjugate aminooxy-functionalized molecules (including fluorescent dyes, polyethylene glycol, or porphyrins) to these entities.
4-Pyridinecarboxaldehyde can be used for the synthesis of: β-Unsaturated amides by coupling with N,N-disubstituted formamides; meso-Substituted A3-corroles; N-(4-pyridylmethyl)-L-valine as a ligand to construct zinc metal–organic frameworks (Zn-MOFs); 4′-Pyridyl terpyridines, with potential application as anticancer and antimicrobial agents; 4-pyridinecarboxaldehyde thiosemicarbazone, as a corrosion inhibitor for mild steel.
Chemical Properties
clear yellow-brown liquid. soluble in water and ether.
Uses
4-Pyridinecarboxaldehyde, is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.
Uses
4-Pyridinecarboxaldehyde can be used for the synthesis of:
- γ,β-Unsaturated amides by coupling with N,N-disubstituted formamides.
- meso-Substituted A3-corroles.
- N-(4-pyridylmethyl)-L-valine as a ligand to construct zinc metal–organic frameworks (Zn-MOFs).
- 4′-Pyridyl terpyridines, with potential application as anticancer and antimicrobial agents.
- 4-pyridinecarboxaldehyde thiosemicarbazone, as a corrosion inhibitor for mild steel.
Application
As a colorless liquid with a pungent odor, 4-Pyridinecarboxaldehyde serves as a component in the synthesis of diverse organic compounds. Its applications extend to the synthesis of pharmaceuticals, fragrances, and pesticides. Moreover, it has proven instrumental in the creation of a wide range of organic compounds, including antioxidants and anti-inflammatory agents.
Preparation
4-Pyridinecarbaldehyde is synthesized by oxidation of 4-picoline. The mixed gas of 4-picoline and air is passed through the vanadium-molybdenum catalyst layer heated to 400°C, and oxidized to generate 4-pyridinecarbaldehyde.
Reactions
4-Pyridinecarboxaldehyde undergoes many reactions expected for aromatic aldehydes such as reductive amination and Schiff base formation. It condenses with pyrrole to give tetrapyridylporphyrin.
Synthesis Reference(s)
Synthetic Communications, 20, p. 3385, 1990 DOI: 10.1080/00397919008051576
Purification Methods
Purified as for pyridine-2-aldehyde. [Beilstein 21 III/IV 2529, 21/7 V 351.]
4-Pyridinecarboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Pyridinecarboxaldehyde manufacturers
- Product
- 4-Pyridinecarboxaldehyde 872-85-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 4-Pyridinecarboxaldehyde 872-85-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- 4-Pyridinecarboxaldehyde 872-85-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-22