ChemicalBook > CAS DataBase List > ML364

ML364

Product Name
ML364
CAS No.
1991986-30-1
Chemical Name
ML364
Synonyms
ML364;ML364, >98%;ML 364;ML-364;ML364 >=98% (HPLC);ML364, 1991986-30-1;ML364, 10 mM in DMSO;Deubiquitinase,Inhibitor,ML 364,DUBs,ML-364,ML364,inhibit;2-((4-Methylphenyl)sulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide;Benzamide, 2-[[(4-methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)-
CBNumber
CB23154506
Molecular Formula
C24H18F3N3O3S2
Formula Weight
517.54
MOL File
1991986-30-1.mol
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ML364 Property

Density 
1.457±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 20 mg/ml
form 
A crystalline solid
pka
6.51±0.50(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21774
Product name
ML-364
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
21774
Product name
ML-364
Purity
≥98%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
21774
Product name
ML-364
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
21774
Product name
ML-364
Purity
≥98%
Packaging
25mg
Price
$396
Updated
2024/03/01
TRC
Product number
M199815
Product name
ML364
Packaging
1mg
Price
$65
Updated
2021/12/16
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ML364 Chemical Properties,Usage,Production

Uses

ML364 is a small molecular inhibitor of the deubiquitinase USP2, which accelerates cyclin D1 degrdation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma.

Biological Activity

ML364 is a potent and specific inhibitor of the deubiquitinase USP2 th at induces cellular Cyclin D1 degradation in HCT116 colorectal cancer cells, followed by cell cycle arrest and apoptosis. Also, ML364 inhibits homologous recombination (HR)-mediated DNA repair.

ML364 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML364 Suppliers

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1991986-30-1, ML364Related Search:

VU0456810 ML277 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide ml390 M348 ML355 ML 141 ML365 ML385 ML216 ML264 PTP1B-IN-2 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML213 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML418 ML188

  • ML364
  • ML364, 1991986-30-1
  • ML 364;ML-364
  • ML364, >98%
  • Benzamide, 2-[[(4-methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)-
  • ML364 >=98% (HPLC)
  • 2-((4-Methylphenyl)sulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide
  • Deubiquitinase,Inhibitor,ML 364,DUBs,ML-364,ML364,inhibit
  • ML364, 10 mM in DMSO
  • 1991986-30-1
  • C24H18F3N3O3S2