ML364
- Product Name
- ML364
- CAS No.
- 1991986-30-1
- Chemical Name
- ML364
- Synonyms
- ML364;ML364, >98%;ML 364;ML-364;ML364 >=98% (HPLC);ML364, 1991986-30-1;ML364, 10 mM in DMSO;Deubiquitinase,Inhibitor,ML 364,DUBs,ML-364,ML364,inhibit;2-((4-Methylphenyl)sulfonamido)-N-(4-phenylthiazol-2-yl)-4-(trifluoromethyl)benzamide;Benzamide, 2-[[(4-methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)-
- CBNumber
- CB23154506
- Molecular Formula
- C24H18F3N3O3S2
- Formula Weight
- 517.54
- MOL File
- 1991986-30-1.mol
ML364 Property
- Density
- 1.457±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 20 mg/ml
- form
- A crystalline solid
- pka
- 6.51±0.50(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21774
- Product name
- ML-364
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 21774
- Product name
- ML-364
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 21774
- Product name
- ML-364
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 21774
- Product name
- ML-364
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $396
- Updated
- 2024/03/01
- Product number
- M199815
- Product name
- ML364
- Packaging
- 1mg
- Price
- $65
- Updated
- 2021/12/16
ML364 Chemical Properties,Usage,Production
Uses
ML364 is a small molecular inhibitor of the deubiquitinase USP2, which accelerates cyclin D1 degrdation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma.
Biological Activity
ML364 is a potent and specific inhibitor of the deubiquitinase USP2 th at induces cellular Cyclin D1 degradation in HCT116 colorectal cancer cells, followed by cell cycle arrest and apoptosis. Also, ML364 inhibits homologous recombination (HR)-mediated DNA repair.