ML329

Product Name: ML329
CAS No.: 19992-50-8
Chemical Name: ML329
Synonyms: ML329;ML329;ML 329;ML-329,ML329,ML 329,Inhibitor,inhibit;4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide;4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide;Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-
CBNumber: CB23171697
Molecular Formula: C16H12N2O4S
Formula Weight: 328.34
MOL File: 19992-50-8.mol

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ML329 Property

storage temp.: 2-8°C(protect from light)
solubility: DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.1 mg/ml
form: A crystalline solid
color: White to off-white

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Safety

HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22481
Product name: ML-329
Purity: ≥98%
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 22481
Product name: ML-329
Purity: ≥98%
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 22481
Product name: ML-329
Purity: ≥98%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

Axon Medchem

Product number: Axon2733
Product name: ML329-CID12387471
Purity: 99%
Packaging: 50mg
Price: $401.5
Updated: 2021/12/16

Axon Medchem

Product number: Axon2733
Product name: ML329-CID12387471
Purity: 99%
Packaging: 10mg
Price: $115.5
Updated: 2021/12/16

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ML329 Chemical Properties,Usage,Production

Definition

ChEBI: 4-[(1,4-dioxo-2-naphthalenyl)amino]benzenesulfonamide is a member of 1,4-naphthoquinones.

Biological Activity

ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM.

in vitro

ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. It could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with it will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. It shows specific activity against the MITF -dependent cells, primary melanocytes but no effect on the viability in A375 cells. It reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, it will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.

target

Target	Value
MITF ()
TRPM-1 promoter < br/> (Cell-free assay)	1.2 μM

ML329 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML329 Suppliers

China 35 India 1 United States 7 USA 1 Global 44

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19992-50-8, ML329Related Search:

ML346 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264

ML329

ML329;ML 329

Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-

4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide

ML-329,ML329,ML 329,Inhibitor,inhibit

4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide

19992-50-8