ChemicalBook > CAS DataBase List > 2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER

2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER

Product Name
2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER
CAS No.
125568-71-0
Chemical Name
2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER
Synonyms
2,4-difluoro-5-nitrobenzoate;Methyl 2,4-difluoro-5-nitrobenzoate 98%;2,4-Dfluoro-5-nitrobenzoic acid methyl ester;2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER;Benzoic acid, 2,4-difluoro-5-nitro-, methyl ester
CBNumber
CB2319845
Molecular Formula
C8H5F2NO4
Formula Weight
217.13
MOL File
125568-71-0.mol
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2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER Property

Boiling point:
310.1±42.0 °C(Predicted)
Density 
1.471±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Sealed in dry,Room Temperature
Appearance
White to light yellow Solid
InChI
InChI=1S/C8H5F2NO4/c1-15-8(12)4-2-7(11(13)14)6(10)3-5(4)9/h2-3H,1H3
InChIKey
KLMBOVOUTOBMLS-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC([N+]([O-])=O)=C(F)C=C1F
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Safety

HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

TRC
Product number
M303788
Product name
Methyl2,4-Difluoro-5-nitrobenzoate
Packaging
100mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
074566
Product name
Methyl 2,4-difluoro-5-nitrobenzoate
Purity
95+%
Packaging
5g
Price
$200
Updated
2021/12/16
AK Scientific
Product number
J97058
Product name
Methyl2,4-difluoro-5-nitrobenzoate
Packaging
5g
Price
$35
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-3-3U
Product name
Methyl 2,4-difluoro-5-nitrobenzoate
Packaging
25g
Price
$264
Updated
2021/12/16
Matrix Scientific
Product number
074566
Product name
Methyl 2,4-difluoro-5-nitrobenzoate
Purity
95+%
Packaging
10g
Price
$286
Updated
2021/12/16
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2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

off-white powder

Synthesis

67-56-1

153775-33-8

125568-71-0

Under argon protection, 2,4-difluoro-5-nitrobenzoic acid (33.0 g, 162 mmol) was dissolved in 400 mL of anhydrous methanol, followed by the addition of 4 mL of concentrated sulfuric acid as a catalyst. The reaction mixture was heated to reflux for 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was redissolved in 400 mL of ether and washed sequentially with saturated aqueous sodium bicarbonate (3 x 200 mL) and brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to afford the target product methyl 2,4-difluoro-5-nitrobenzoate (32.6 g, 92% yield). The product was analyzed by APCI-MS showing a molecular ion peak m/z of 217.0, and analytical HPLC detection showed a retention time of 15.7 min and a purity greater than 99%.

References

[1] Patent: WO2007/19674, 2007, A1. Location in patent: Page/Page column 45
[2] Patent: JP2018/508527, 2018, A. Location in patent: Paragraph 0212; 0213
[3] Patent: WO2008/84300, 2008, A1. Location in patent: Page/Page column 28
[4] Patent: WO2009/75960, 2009, A1. Location in patent: Page/Page column 22
[5] Patent: WO2009/58919, 2009, A1. Location in patent: Page/Page column 22-23

2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER Suppliers

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View Lastest Price from 2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co
Product
2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER 125568-71-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-24

125568-71-0, 2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTERRelated Search:

Dimethyl carbonate 2-FLUORO-5-NITROBENZYL ALCOHOL 96 Methyl 5-amino-2,4-difluorobenzoate METHYL 5-AMINO-2-FLUOROBENZOATE METHYL 3-AMINO-4-FLUOROBENZENECARBOXYLATE 2-Fluoro-5-nitrobenzoic acid 4-Fluoro-3-nitrobenzoic acid 4-FLUORO-3-NITROBENZYL ALCOHOL 96 2,4-DIFLUORO-5-NITROBENZOIC ACID 4-FLUORO-3-NITROBENZALDEHYDE METHYL 2-FLUORO-5-NITROBENZOATE 3-Amino-4-fluorobenzoic acid Methyl 4-fluoro-3-nitrobenzoate 2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER

  • Methyl 2,4-difluoro-5-nitrobenzoate 98%
  • 2,4-DIFLUORO-5-NITROBENZOIC ACID METHYL ESTER
  • 2,4-Dfluoro-5-nitrobenzoic acid methyl ester
  • 2,4-difluoro-5-nitrobenzoate
  • Benzoic acid, 2,4-difluoro-5-nitro-, methyl ester
  • 125568-71-0
  • C8H5F2NO4