m-(Trifluoromethyl)phenylacetic acid
- Product Name
- m-(Trifluoromethyl)phenylacetic acid
- CAS No.
- 351-35-9
- Chemical Name
- m-(Trifluoromethyl)phenylacetic acid
- Synonyms
- 2-(3-(TRIFLUOROMET;TIMTEC-BB SBB000433;RARECHEM AL BO 0127;m-(Trifluoromethyl)p;Inter-trifluoroMethyl acid;3-(TriflurorMethyl)benzylbroMide;3-TRIFLUOROMETHYPHENYLACETIC ACID;3-(Carboxymethyl)benzotrifluoride;(A,A,A-TRIFLUORO-M-TOLYL)ACETIC ACID;3-(trifluoromethyl)-benzeneaceticaci
- CBNumber
- CB2336956
- Molecular Formula
- C9H7F3O2
- Formula Weight
- 204.15
- MOL File
- 351-35-9.mol
m-(Trifluoromethyl)phenylacetic acid Property
- Melting point:
- 76-79 °C(lit.)
- Boiling point:
- 238C/775Torr
- Density
- 1.357±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.14±0.10(Predicted)
- color
- White to Almost white
- BRN
- 2213223
- InChI
- InChI=1S/C9H7F3O2/c10-9(11,12)7-3-1-2-6(4-7)5-8(13)14/h1-4H,5H2,(H,13,14)
- InChIKey
- BLXXCCIBGGBDHI-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=CC(C(F)(F)F)=C1
- CAS DataBase Reference
- 351-35-9(CAS DataBase Reference)
- EPA Substance Registry System
- Benzeneacetic acid, 3-(trifluoromethyl)- (351-35-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- TSCA
- T
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 193356
- Product name
- 3-(Trifluoromethyl)phenylacetic acid
- Purity
- 97%
- Packaging
- 10g
- Price
- $78.4
- Updated
- 2025/07/31
- Product number
- T1662
- Product name
- 3-(Trifluoromethyl)phenylacetic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- T1662
- Product name
- 3-(Trifluoromethyl)phenylacetic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $152
- Updated
- 2025/07/31
- Product number
- 002139
- Product name
- 3-(Trifluoromethyl)phenylacetic Acid
- Purity
- 97%
- Packaging
- 100g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- O788
- Product name
- 3-(Trifluoromethyl)phenylacetic Acid
- Packaging
- 100g
- Price
- $251
- Updated
- 2021/12/16
m-(Trifluoromethyl)phenylacetic acid Chemical Properties,Usage,Production
Chemical Properties
white to pale yellow crystalline powder
Uses
m-(Trifluoromethyl)phenylacetic acid is used as a reactant in a mechanistic study on ligand-accelerated C-H activation reactions.
Synthesis
2338-76-3
351-35-9
General procedure for the synthesis of [3-(trifluoromethyl)phenyl]acetic acid from [3-(trifluoromethyl)phenyl]acetonitrile: [3-(trifluoromethyl)phenyl]acetonitrile (5.4 g, 0.03 mol) was mixed with an aqueous solution of sodium hydroxide (6 g, 0.15 mol) and heated to reflux overnight. Upon completion of the reaction, it was cooled to room temperature and the pH of the reaction solution was adjusted with dilute hydrochloric acid to 2. Subsequently, the precipitate precipitated was collected by filtration, washed with water and dried to afford [3-(trifluoromethyl)phenyl]acetic acid as a white solid (5.2 g, 87% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 7.6 (m, 4H, aromatic hydrogen), 3.7 (s, 2H, CH2).
References
[1] Patent: WO2008/104524, 2008, A1. Location in patent: Page/Page column 49
[2] Journal of medicinal chemistry, 1968, vol. 11, # 6, p. 1258 - 1262
[3] Arzneimittel Forschung, 1965, vol. 15, p. 1251 - 1253
[4] Journal of the American Chemical Society, 1977, vol. 99, # 9, p. 3059 - 3067
[5] Journal of the American Chemical Society, 1982, vol. 104, # 7, p. 1937 - 1951
m-(Trifluoromethyl)phenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
m-(Trifluoromethyl)phenylacetic acid Suppliers
- Tel
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- Fax
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- interchim@interchim.com
- Country
- France
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- 6302
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View Lastest Price from m-(Trifluoromethyl)phenylacetic acid manufacturers
- Product
- m-(Trifluoromethyl)phenylacetic acid 351-35-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-26
- Product
- m-(Trifluoromethyl)phenylacetic acid 351-35-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1KG
- Release date
- 2024-05-30
- Product
- m-(Trifluoromethyl)phenylacetic acid 351-35-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- 1ton
- Release date
- 2019-12-18