5-Bromoisatoic anhydride
- Product Name
- 5-Bromoisatoic anhydride
- CAS No.
- 4692-98-2
- Chemical Name
- 5-Bromoisatoic anhydride
- Synonyms
- AKOS BBS-00002893;5-Bromoisatoicacid;5-BROMOISATOIC ANHYDRIDE;5-Bromoisoatoic anhydride;5-BromoisatoicAnhydride>5-Bromoisatoic anhydride,97%;5-BROMOISATOIC ANHYDRIDE 90%;5-Bromoisatoic anhydride 95+%;5-Bromoisatoic anhydride, 90% min;5-BROMOISATOIC ANHYDRIDE, TECH., 90%
- CBNumber
- CB2341787
- Molecular Formula
- C8H4BrNO3
- Formula Weight
- 242.03
- MOL File
- 4692-98-2.mol
5-Bromoisatoic anhydride Property
- Melting point:
- 280-285 °C (dec.) (lit.)
- Density
- 1.826±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Dimethylformamide
- form
- powder to crystal
- pka
- 9.81±0.20(Predicted)
- color
- White to Light yellow to Light orange
- CAS DataBase Reference
- 4692-98-2(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 61-20/21-36/37/38
- Safety Statements
- 53-23-36/37/39-45
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 477702
- Product name
- 5-Bromoisatoic anhydride
- Purity
- 97%
- Packaging
- 5g
- Price
- $320
- Updated
- 2023/06/20
- Product number
- B3659
- Product name
- 5-Bromoisatoic Anhydride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $134
- Updated
- 2025/07/31
- Product number
- B684653
- Product name
- 5-Bromoisatoic anhydride
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W017781
- Product name
- 6-Bromo-2H-benzo[d][1,3]oxazine-2,4(1H)-dione
- Purity
- 97.56%
- Packaging
- 25g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- FB42908
- Product name
- 5-Bromoisatoic anhydride
- Packaging
- 5G
- Price
- $100
- Updated
- 2021/12/16
5-Bromoisatoic anhydride Chemical Properties,Usage,Production
Chemical Properties
Off-white to salmon powder
Uses
5-Bromoisatoic anhydride is an important chemical raw material and pharmaceutical intermediate, mainly used in laboratory research and development processes and chemical production processes.
Preparation
5-Bromoisatoic anhydride is prepared from 5-bromo indole by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
1HNMR(DMSO-d6): δ 11.85 (s, br., 1H), 7.96 (dd, J = 0.8, 8.7 Hz, 1H), 7.87 (dd, J = 2.3, 8.7 Hz, 1H), 7.09 (dd, J = 8.8, 0.8 Hz, 1H).
Synthesis
87-48-9
4692-98-2
General procedure for the synthesis of 6-bromo-2H-benzo[d][1,3]oxazine-2,4(1H)-dione using 5-bromoindigo red as starting material: 5-bromoindigo red (II) (20.0 g, 88.49 mmol) was uniformly dispersed in dichloromethane (300 mL), and m-chloroperoxybenzoic acid (22.91 g, 132.73 mmol) was added in batches at room temperature. at room temperature. The reaction mixture was stirred at room temperature for 2 h. The reaction progress was monitored by thin layer chromatography (TLC) to confirm the completion of the reaction. Subsequently, the reaction system was cooled to 10°C with continuous stirring and sodium bisulfite solution was slowly added dropwise until the starch potassium iodide paper no longer showed color. The reaction solution was concentrated by rotary evaporation to remove dichloromethane, 50 mL of water was added to mix well with the residue, and then saturated sodium bicarbonate solution was added dropwise until no bubbles were produced. The resulting solid was collected by filtration, washed with a small amount of water and dried at 50 °C to give 20.99 g of 5-bromoisatoindirubic anhydride (III) in 98% yield.
References
[1] Patent: CN106632276, 2017, A. Location in patent: Paragraph 0112; 0113; 0114
[2] Angewandte Chemie, 1980, vol. 92, # 3, p. 196 - 197
[3] Catalysis Science and Technology, 2015, vol. 5, # 10, p. 4830 - 4838
[4] Patent: CN103570726, 2016, B. Location in patent: Paragraph 0085; 0086; 0087
[5] Journal fuer Praktische Chemie (Leipzig), 1886, vol. <2> 33, p. 36
5-Bromoisatoic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromoisatoic anhydride Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
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- Country
- Americas
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- Advantage
- 75
View Lastest Price from 5-Bromoisatoic anhydride manufacturers
- Product
- 5-Bromo isatoic anhydride 4692-98-2
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-29
- Product
- 5-Bromoisatoic anhydride 4692-98-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-19
- Product
- 5-Bromoisatoic anhydride 4692-98-2
- Price
- US $8.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28