Succinimidyl 6-(biotinamido)hexanoate

Product Name: Succinimidyl 6-(biotinamido)hexanoate
CAS No.: 72040-63-2
Chemical Name: Succinimidyl 6-(biotinamido)hexanoate
Synonyms: Bachs;BIOTIN-X-NHS;BIOTIN-X, SE;NHS-X-Biotin;D-Biotiamide;NHS-LC-BIOTIN;BIOTIN-LC-OSU;Biotin-LC-NHS;Biotin-NHS LC;BIOTIN-AC5-OSU
CBNumber: CB2343655
Molecular Formula: C20H30N4O6S
Formula Weight: 454.54
MOL File: 72040-63-2.mol

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Succinimidyl 6-(biotinamido)hexanoate Property

Melting point:: 169-171 °C
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: H₂O: ≤2 mg/mL with sonication
form: powder
pka: 13.90±0.40(Predicted)
color: White to Off-White
Water Solubility: H2O: ≤2mg/mL (with sonication)
DMF: 50mg/mL (Stable up to 2 months in dry DMF.)
BRN: 3577403
Stability:: Moisture Sensitive
InChIKey: UVGHPGOONBRLCX-NJSLBKSFSA-N
CAS DataBase Reference: 72040-63-2(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
F: 10-21
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B2643
Product name: Biotinamidohexanoic acid N-hydroxysuccinimide ester
Purity: ≥98% (TLC), powder
Packaging: 10mg
Price: $45.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: B2643
Product name: Biotinamidohexanoic acid N-hydroxysuccinimide ester
Purity: ≥98% (TLC), powder
Packaging: 25mg
Price: $121
Updated: 2024/03/01

Sigma-Aldrich

Product number: 203189
Product name: Biotin-X-NHS, Water-Soluble
Packaging: 50MG
Price: $764
Updated: 2024/03/01

TCI Chemical

Product number: S0490
Product name: N-Succinimidyl 6-Biotinamidohexanoate
Purity: >97.0%(HPLC)
Packaging: 20mg
Price: $52
Updated: 2024/03/01

TCI Chemical

Product number: S0490
Product name: N-Succinimidyl 6-Biotinamidohexanoate
Purity: >97.0%(HPLC)
Packaging: 100mg
Price: $166
Updated: 2024/03/01

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Succinimidyl 6-(biotinamido)hexanoate Chemical Properties,Usage,Production

Description

Biotin-LC-NHS Ester has an extended spacer arm which helps to minimize steric hindrance. The membrane permeability of this reagent allows it to be used for intracellular labeling. It can react efficiently with primary amino (-NH2) to form stable, irreversible amide bonds.

Chemical Properties

Succinimidyl 6-(biotinamido)hexanoate is White Solid

Uses

Succinimidyl 6-(biotinamido)hexanoate is a biotinylation reagent incorporating an aminocaproyl “spacer”. This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture System. This system avoids the direct interaction of a captured antibody with solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Has also been used as a cell surface labelling reagent

Uses

Has been used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin solid surfaces, such as plastics, which may reduce antigenicity. It has also been used to enhance the detection of DNA on nitrocellulose. Spacer Arm:

Uses

A biotinylation reagent incorporating an aminocaproyl pacer? This can reduce the steric hindrance in binding avidin to some biotinylated compounds when used to biotinylate both the antibody and the carrier in the Protein Avidin-Biotin Capture Sy

Biological Activity

nhs-lc-biotin (succinimidyl-6-(biotinamindo)hexanoate), also known as nhs-x-biotin is a derivative of d-biotin, a amine-reactive biotinylation agent, that contains a spacer arm off the valeric acid side chain of d-biotin with an nhs ester group at its end. the nhs ester group at the end of nhs-lc-biotin covalently binds to amine groups in proteins and other molecules forming a stable amide linkage and releasing the nhs group. the 6-aminocaproic acid spacer of nhs-lc-biotin greatly increases the length between a covalently modified molecule and the bicyclic biotin rings leading to a better binding potential for avidin or streptavidin probes. nhs-lc-biotin is insoluble in aqueous environments requiring the dissolution of organic solvents prior to the addition to a buffered reaction.bioconjugate techniques , 2nd ed. by greg t.hermanson (pierce biotechnology, thermo fisher scientific, rockford, il). academic press (an imprint of elsevier): london, amsterdam, burlington, san diego . 2008. isbn 978-0-12-370501-3.

storage

Store at -20°C

Purification Methods

Dissolve ~400mg of the ester in dry propan-2-ol (~25mL) with gentle heating. Reduce the volume to ~10mL by gentle boiling and allow the solution to cool. Decant the supernatant carefully from the white crystals, dry the crystals in a vacuum over P2O5 at 60o overnight. This material gives one spot on TLC. [Costello et al. Clin Chem 25 1572 1979, Kincaid et al. Methods Enzymol 159 619 1988.]

Succinimidyl 6-(biotinamido)hexanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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R&D Scientific Inc.

Product: D-Biotiamide 72040-63-2
Price: US $6500.00/G
Min. Order: 1G
Purity: 97
Supply Ability: 500 Kg
Release date: 2024-06-23

Xian confluore Biological Technology Co., Ltd.

Product: Biotin-LC-NHS 72040-63-2
Price: US $0.00/g
Min. Order: 5g
Purity: >95.00%
Supply Ability: 5g
Release date: 2024-03-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: Succinimidyl 6-(biotinamido)hexanoate 72040-63-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

72040-63-2, Succinimidyl 6-(biotinamido)hexanoateRelated Search:

Diethyl phthalate 6-Aminocaproic acid Tris(trimethylsilyl)phosphate Cholesteryl hexanoate N-Chlorosuccinimide Succinimide BIOTIN-NHS Dimethyl succinate SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE N,N'-DIMETHYL-1,8-OCTANEDIAMINE 6-Acetamidohexanoic acid 2-METHYLTETRAHYDROTHIOPHENE N-Hydroxysuccinimide AcidEster LUTEINESTER (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID SULPHOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE Succinimidyl 6-(biotinamido)hexanoate

6-[5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-4-YL)-PENTANOYLAMINO]-HEXANOIC ACID 3-HYDROPEROXYSULFONYL-2,5-DIOXO-PYRROLIDIN-1-YL ESTER SODIUM SALT

D-BIOTIN-AMIDOCAPROATE-N-HYDROXYSUCCINIMIDE ESTER

D-BIOTINOYL-EPSILON-AMINOCAPROIC ACID-N-HYDROXYSUCCINIMIDE ESTER

D-BIOTINYL-EPSILON-AMINOCAPROIC ACID-N-HYDROXY-SUCCINIMIDE ESTER

BIOTINYL-EPSILON-AMINOCAPROIC ACID-N-HYDROXYSUCCINIMIDE ESTER

BIOTIN-X-NHS

BIOTIN-X-NHS, WATER-SOLUBLE

BIOTIN-X, SE

BIOTIN-X, SUCCINIMIDYL ESTER

6-((BIOTINOYL)AMINO)HEXANOIC ACID, SUCCINIMIDYL ESTER

6-[(+)-BIOTINYL]AMINOCAPROIC ACID N-HYDROXYSUCCINIMDE ESTER

BiotinamidohexanoicacidN-hydroxysuccinimideester(biotin)

BIOTIN-AC5-OSU

Biotinamidohexanoic acid N-hydroxysuccinimide ester

(+)-Bioyinamidocaproate N-hydroxysuccinimidyl ester

N-SUCCINIMIDYL N-BIOTINYL-6-AMINOCAPROATE

NHS-LC-BIOTIN

SULFO-NHS-LC-BIOTIN

SULFOSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE

SULFOSSUCCINIMIDYL-6-(BIOTINAMIDO)HEXANOATE

SUCCINIMIDYL 6-[BIOTINAMIDO]HEXANOATE

SULFOBIOTIN-X-NHS

SULFO LC BIOTIN

6-(Biotinylamino)hexanoicacidN-hydroxysuccimideester

biotinyl-6-aminocaproic acid N-hydroxysuccinimide ester

(+)-biotinyl-6-aminocaproic actd

N-(+)-BINTINY-6-AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER (+)-BIOTINY-6-AMINOCAPROIC ACTD

Succinimidyl-6-biotinamide hexanoate

2,5-Dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6aR)

2,5-Dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)penta

Biotinamidohexanoic acidN-hydroxysuccinimide ester≥ 97% (HPLC)

Biotinyl-ε-aminocaproic acid-N-hydroxysuccinimide ester

Biotin-X, succinimidyl ester *CAS 72040-63-2*

BIOTINYLAMIDOCAPROIC ACID-N-HYDROXYSUCCINIMIDE ESTER

BIOTINAMIDOCAPROATE N-HYDROXYSUCCINIMIDE ESTER

(+)-BIOTINAMIDOCAPROATE N-HYDROXYSUCCINIMIDYL ESTER

BIOTINAMIDOCAPROATE, N-HYDROXYSUCCINIMIDYL ESTER

BIOTIN-LC-OSU

N-(+)-BIOTINYL-6-AMINOCAPROIC ACID N-SUCCINIMIDYL ESTER

Biotin-X, SE [Biotimidohexanoic acid N-hydroxysuccinimide ester]

Biotin-N-succinimidyl-amidohexanoate

CAS_72040-63-2

(+)-Biotinamidocaproate N-hydroxysuccinimidyl ester, N-(+)-Biotinyl-6-aminocaproic acid N-succinimidyl ester, N-(+)-Biotinyl-6-aminohexanoic acid NHS ester, N-Succinimidyl N-biotinyl-6-aminocaproate, Succinimidyl 6-(biotinamido)hexanoate

LC-NHS-(+)-Biotin

N-(+)-Biotinyl-6-aminohexanoic acid NHS ester

1H-Thieno(3,4-D)imidazole-4-pentanamide, N-(6-((2,5-dioxo-1-pyrrolidinyl)oxy)-6-oxohexyl)hexahydro-2-oxo-, (3as-(3aalpha,4beta,6aalpha))-

1H-Thieno(3,4-D)imidazole-4-pentanamide, N-(6-((2,5-dioxo-1-pyrrolidinyl)oxy)-6-oxohexyl)hexahydro-2-oxo-, (3as,4S,6ar)-

Bachs

Biotinyl-epsilon-aminohexanoic acid N-hydroxysuccinimide ester

N-Biotinyl-epsilon-aminocaproic acid N-hydroxysuccinimide ester

Biotinamidohexanoic acid N-hydroxysuccinimide ester,(+)-Biotinamidocaproate N-hydroxysuccinimidyl ester, N-(+)-Biotinyl-6-aminocaproic acid N-succinimidyl ester, N-(+)-Biotinyl-6-aminohexanoic acid NH

Biotin-6-aMinohexanoic acid-N-hydroxysucciniMide ester

Biotin-LC-NHS

2,5-dioxopyrrolidin-1-yl 6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]iMidazol-4-yl)pentanaMido)hexanoate

N-SucciniMidyl 6-BiotinaMidohexanoate

Hexanoic acid, 6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]iMidazol-4-yl]-1-oxopentyl]aMino]-, 2,5-dioxo-1-pyrrolidinyl ester

NHS-X-Biotin

Biotin-NHS LC