ChemicalBook > CAS DataBase List > 5-Hydroxy-2-methylindole

5-Hydroxy-2-methylindole

Product Name
5-Hydroxy-2-methylindole
CAS No.
13314-85-7
Chemical Name
5-Hydroxy-2-methylindole
Synonyms
5-Hydroxy-2-methyL;2-Methyl-5-Indanone;2-METHYL-1H-INDOL-5-OL;5-Hydroxy-2-methylindol;1H-Indol-5-ol,2-Methyl-;5-HYDROXY-2-METHYLINDOLE;5-Hydroxy-2-methylindole,98%;5-Hydroxy-2-Methyl-1H-indole
CBNumber
CB2351265
Molecular Formula
C9H9NO
Formula Weight
147.17
MOL File
13314-85-7.mol
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5-Hydroxy-2-methylindole Property

Melting point:
130-132℃
Boiling point:
344.8±22.0 °C(Predicted)
Density 
1.262±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form 
Solid
pka
10.05±0.40(Predicted)
color 
Brown
Sensitive 
Light Sensitive
CAS DataBase Reference
13314-85-7(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M321593
Product name
2-Methyl-1H-indol-5-ol
Packaging
10mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
138117
Product name
2-Methyl-1H-indol-5-ol
Purity
95%+
Packaging
2.500g
Price
$215
Updated
2021/12/16
AK Scientific
Product number
Z4093
Product name
2-Methyl-1H-indol-5-ol
Packaging
10g
Price
$270
Updated
2021/12/16
Matrix Scientific
Product number
138117
Product name
2-Methyl-1H-indol-5-ol
Purity
95%+
Packaging
5g
Price
$323
Updated
2021/12/16
Matrix Scientific
Product number
138117
Product name
2-Methyl-1H-indol-5-ol
Purity
95%+
Packaging
1g
Price
$101
Updated
2021/12/16
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5-Hydroxy-2-methylindole Chemical Properties,Usage,Production

Application

5-Hydroxy-2-methylindole is a useful research chemical.

Synthesis

1076-74-0

13314-85-7

The general procedure for the synthesis of 5-hydroxy-2-methylindole from 5-methoxy-2-methylindole was as follows: a solution of boron tribromide (32.5 mL, 341 mmol) in dichloromethane (60 mL) was added batchwise to a solution of 5-methoxy-2-methylindole (25 g, 155 mmol) in dichloromethane (250 mL) that had been cooled to -50 °C. After stirring the reaction mixture at -30 °C for 15 min, it was slowly warmed to room temperature and stirring was continued for 1 hour. Subsequently, dichloromethane (300 mL) was added in batches and the reaction mixture was cooled to 0 °C. Water was slowly added and the pH of the mixture was adjusted to 6 with 4N sodium hydroxide solution. the organic layer was separated and the aqueous layer was extracted with dichloromethane. All organic layers were combined, washed sequentially with water and saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure and the resulting crude product was purified by column chromatography with the eluent ethyl acetate/dichloromethane (initial ratio 1:9, subsequently adjusted to 15:85) to give 5-hydroxy-2-methylindole (21.2 g, 93% yield) as a white solid.

References

[1] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 578 - 588
[2] Patent: US2003/212055, 2003, A1
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 1940 - 1956
[4] Research on Chemical Intermediates, 2010, vol. 36, # 8, p. 975 - 983
[5] Bioorganic and medicinal chemistry, 2004, vol. 12, # 17, p. 4685 - 4700

5-Hydroxy-2-methylindole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Hydroxy-2-methylindole Suppliers

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View Lastest Price from 5-Hydroxy-2-methylindole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Hydroxy-2-methylindole 13314-85-7
Price
US $9.85/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 m
Release date
2024-11-29
Henan Aochuang Chemical Co.,Ltd.
Product
5-Hydroxy-2-methylindole 13314-85-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Career Henan Chemical Co
Product
5-Hydroxy-2-methylindole 13314-85-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

13314-85-7, 5-Hydroxy-2-methylindoleRelated Search:

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  • 5-HYDROXY-2-METHYLINDOLE
  • 2-METHYL-1H-INDOL-5-OL
  • 2-Methyl-5-Indanone
  • 5-Hydroxy-2-Methyl-1H-indole
  • 1H-Indol-5-ol,2-Methyl-
  • 5-Hydroxy-2-methylindol
  • 5-Hydroxy-2-methyL
  • 5-Hydroxy-2-methylindole,98%
  • 13314-85-7
  • pharmacetical
  • Indoles
  • Indoles and derivatives