5-Hydroxy-2-methylindole
- Product Name
- 5-Hydroxy-2-methylindole
- CAS No.
- 13314-85-7
- Chemical Name
- 5-Hydroxy-2-methylindole
- Synonyms
- 5-Hydroxy-2-methyL;2-Methyl-5-Indanone;2-METHYL-1H-INDOL-5-OL;5-Hydroxy-2-methylindol;1H-Indol-5-ol,2-Methyl-;5-HYDROXY-2-METHYLINDOLE;5-Hydroxy-2-methylindole,98%;5-Hydroxy-2-Methyl-1H-indole
- CBNumber
- CB2351265
- Molecular Formula
- C9H9NO
- Formula Weight
- 147.17
- MOL File
- 13314-85-7.mol
5-Hydroxy-2-methylindole Property
- Melting point:
- 130-132℃
- Boiling point:
- 344.8±22.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- Solid
- pka
- 10.05±0.40(Predicted)
- color
- Brown
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 13314-85-7(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M321593
- Product name
- 2-Methyl-1H-indol-5-ol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 138117
- Product name
- 2-Methyl-1H-indol-5-ol
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- Z4093
- Product name
- 2-Methyl-1H-indol-5-ol
- Packaging
- 10g
- Price
- $270
- Updated
- 2021/12/16
- Product number
- 138117
- Product name
- 2-Methyl-1H-indol-5-ol
- Purity
- 95%+
- Packaging
- 5g
- Price
- $323
- Updated
- 2021/12/16
- Product number
- 138117
- Product name
- 2-Methyl-1H-indol-5-ol
- Purity
- 95%+
- Packaging
- 1g
- Price
- $101
- Updated
- 2021/12/16
5-Hydroxy-2-methylindole Chemical Properties,Usage,Production
Application
5-Hydroxy-2-methylindole is a useful research chemical.
Synthesis
1076-74-0
13314-85-7
The general procedure for the synthesis of 5-hydroxy-2-methylindole from 5-methoxy-2-methylindole was as follows: a solution of boron tribromide (32.5 mL, 341 mmol) in dichloromethane (60 mL) was added batchwise to a solution of 5-methoxy-2-methylindole (25 g, 155 mmol) in dichloromethane (250 mL) that had been cooled to -50 °C. After stirring the reaction mixture at -30 °C for 15 min, it was slowly warmed to room temperature and stirring was continued for 1 hour. Subsequently, dichloromethane (300 mL) was added in batches and the reaction mixture was cooled to 0 °C. Water was slowly added and the pH of the mixture was adjusted to 6 with 4N sodium hydroxide solution. the organic layer was separated and the aqueous layer was extracted with dichloromethane. All organic layers were combined, washed sequentially with water and saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure and the resulting crude product was purified by column chromatography with the eluent ethyl acetate/dichloromethane (initial ratio 1:9, subsequently adjusted to 15:85) to give 5-hydroxy-2-methylindole (21.2 g, 93% yield) as a white solid.
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 578 - 588
[2] Patent: US2003/212055, 2003, A1
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 5, p. 1940 - 1956
[4] Research on Chemical Intermediates, 2010, vol. 36, # 8, p. 975 - 983
[5] Bioorganic and medicinal chemistry, 2004, vol. 12, # 17, p. 4685 - 4700
5-Hydroxy-2-methylindole Preparation Products And Raw materials
Raw materials
Preparation Products
5-Hydroxy-2-methylindole Suppliers
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- Switzerland
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View Lastest Price from 5-Hydroxy-2-methylindole manufacturers
- Product
- 5-Hydroxy-2-methylindole 13314-85-7
- Price
- US $9.85/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 m
- Release date
- 2024-11-29
- Product
- 5-Hydroxy-2-methylindole 13314-85-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
- Product
- 5-Hydroxy-2-methylindole 13314-85-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11