Desogestrel

Product Name: Desogestrel
CAS No.: 54024-22-5
Chemical Name: Desogestrel
Synonyms: Desogestrel for system suitability CRS;Desogen;Desogestrel CRS;org2969;Cyclosa;Dicromil;DESTODENE;Cerazette;DESOGESTREL;DESOGESTRAL
CBNumber: CB2359630
Molecular Formula: C22H30O
Formula Weight: 310.47
MOL File: 54024-22-5.mol

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Desogestrel Property

Melting point:: 109-110°C
alpha: D20 +55° (chloroform)
Boiling point:: 390.62°C (rough estimate)
Density: 1.0169 (rough estimate)
refractive index: 1.5100 (estimate)
storage temp.: -20°C Freezer
solubility: Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride.
pka: 13.07±0.40(Predicted)
form: Solid
color: White to Almost white
Merck: 14,2926

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Safety

Safety Statements: 24/25
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
RTECS: JF7975000
HS Code: 29372390
Hazardous Substances Data: 54024-22-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1173235
Product name: Desogestrel
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: 32809
Product name: Desogestrel
Purity: VETRANAL
Packaging: 25mg
Price: $164
Updated: 2022/05/15

Sigma-Aldrich

Product number: 1173235
Product name: Desogestrel
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $452
Updated: 2022/05/15

TCI Chemical

Product number: D4163
Product name: Desogestrel
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $159
Updated: 2024/03/01

Cayman Chemical

Product number: 23651
Product name: Desogestrel
Purity: ≥95%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

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Desogestrel Chemical Properties,Usage,Production

Description

Desogestrel is a synthetic progestogen. It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine 123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8⁺ T cells in a dose-dependent manner. Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.

Chemical Properties

White Solid

Originator

Dicromil,Organol ,W. Germany,1981

Uses

A progestogen with low androgenic potency

Definition

ChEBI: Desogestrel is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive.

Manufacturing Process

A solution of 1.0 g of 11,11-methylene-18-methyl-delta4-estren-17-one in 33 ml tetrahydrofuran was added to a potassium-acetylide solution in tetrahydrofuran.
After 2 hours of stirring at 0°C to 5°C the reaction mixture was acidified with 2N H2SO4and processed further.
By a chromatographic treatment on silica gel and crystallization from pentane 0.7 g of 11,11-methylene-17α-ethynyl-18-methyl-δ4-estren-17β-ol with a melting point of 109°C to 110°C and an [α]D of +55°C (CHCl3) was obtained.

Therapeutic Function

Progestin

General Description

Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.

Clinical Use

Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.

Desogestrel Preparation Products And Raw materials

Raw materials

ESTRONE(RG) 1,2-Ethanedithiol Sodium borohydride Ammonia

Preparation Products

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Desogestrel Suppliers

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View Lastest Price from Desogestrel manufacturers

Sinoway Industrial co., ltd.

Product: Desogestrel 54024-22-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20tons
Release date: 2024-03-13

Shaanxi Dideu Medichem Co. Ltd

Product: Desogestrel 54024-22-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Nantong Guangyuan Chemicl Co,Ltd

Product: Desogestrel 54024-22-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-01

54024-22-5, DesogestrelRelated Search:

chlorempenthrin Ethylparaben ISOXADIFEN-ETHYL Ethanol Empenthrin Methyl 2-hydroxyethyl cellulose Ethyl acrylate 4,4'-Diphenylmethane diisocyanate Methylene Blue Ethyl acetate Methylene Chloride 2-Butanone 3-KETO DESOGESTREL Lynestrenol Pregnenolone acetate 16,17-Epoxypregnenolone 16,17-Epoxypregnenolone acetate 3-Hydroxy-desestrel

13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol

(17α)-13-Ethyl-11-methylene-18，19-dinorpregn-4-en-20-yn-17-ol

(8S,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol

(17R)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol

(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol

Desogestrel (50 mg)

DESTODENE

Desogestrel for system suitability, European Pharmacopoeia (EP) Reference Standard

Desogestrel, >=99%

(8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-Methylene-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

13-ethyl-11-methylene-19-dinorpregn-4-en-20-yn-17-o(17-alpha)-1

org2969

13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol

DESOGESTREL

(17a)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol

Cerazette

Cyclosa

Dicromil

Marvelon 150/320

18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17.alpha.)-

(17β)-13-Ethyl-11-methylene-19-nor-pregn-4-en-20-yn-17-ol

DESOGESTRAL

13-Ethyl-11-methylene-18,19-dinor-17α-4-pregnen-20-yn-17-ol

Desogestrel, 99%, a third-generation 19-nortestosterone derivative progestogen

Desogestrel Solution

Desogestrel for system suitability CRS

Desogestrel CRS

Desogestrel&gt

Desogen

Desogestrelum

18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17α)-

Desogestrel USP/EP/BP

DesogestrelQ: What is Desogestrel Q: What is the CAS Number of Desogestrel Q: What is the storage condition of Desogestrel Q: What are the applications of Desogestrel

Desogestrel (1173235)

Desogestrol

Desogestrel Solution in Methanol

Desogestre!

54024-22-5

C22H30O

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