2-Phenylacetamide

Product Name: 2-Phenylacetamide
CAS No.: 103-81-1
Chemical Name: 2-Phenylacetamide
Synonyms: Benzeneacetamide;PHENYLACETAMIDE;Phenylacetic acid amide;-Toluamide;α-Toluamide;Phenacetamide;ALPHA-TOLUAMIDE;2-Pheylacetamide;PHENYLETHANAMIDE;2-PHENYLACETAMIDE
CBNumber: CB2360953
Molecular Formula: C8H9NO
Formula Weight: 135.16
MOL File: 103-81-1.mol

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2-Phenylacetamide Property

Melting point:: 156 °C
Boiling point:: 280-290 °C (dec.)
Density: 1.1031 (rough estimate)
refractive index: 1.5589 (estimate)
storage temp.: Refrigerator
solubility: Soluble in methanol.
pka: 16.21±0.40(Predicted)
form: Solid
color: Plates or leaflets
Merck: 14,7266
InChI: InChI=1S/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)
InChIKey: LSBDFXRDZJMBSC-UHFFFAOYSA-N
SMILES: C1(CC(N)=O)=CC=CC=C1
CAS DataBase Reference: 103-81-1(CAS DataBase Reference)
NIST Chemistry Reference: Benzeneacetamide(103-81-1)
EPA Substance Registry System: Benzeneacetamide (103-81-1)

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Safety

Hazard Codes: Xi
Risk Statements: 22-36
Safety Statements: 22-24/25-60-36-26
RTECS: AC7705000
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29242990
Toxicity: LD50 ipr-mus: 430 mg/kg PCJOAU 10,579,76

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P0120
Product name: 2-Phenylacetamide
Purity: >98.0%(N)
Packaging: 25g
Price: $40
Updated: 2024/03/01

TCI Chemical

Product number: P0120
Product name: 2-Phenylacetamide
Purity: >98.0%(N)
Packaging: 500g
Price: $286
Updated: 2024/03/01

Alfa Aesar

Product number: H60626
Product name: 2-Phenylacetamide, 99%
Packaging: 250mg
Price: $52.4
Updated: 2024/03/01

TRC

Product number: P335554
Product name: 2-Phenylacetamide
Packaging: 100g
Price: $105
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK439749
Product name: 2-Phenylacetamide
Purity: 98%
Packaging: 100g
Price: $146
Updated: 2021/12/16

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2-Phenylacetamide Chemical Properties,Usage,Production

Chemical Properties

2-Phenylacetamide, also known as alpha-toluamide or benzeneacetamide, belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids. Pure crystals are plate shaped and colorless to white. soluble in hot water, ethanol, slightly soluble in cold water, ether and benzene.

Uses

In agriculture, 2-Phenylacetamid can be used in the production of many important intermediates of pesticides, such as carbamine. In the field of dyes: it can react with some monomers with color to produce some important raw materials for blue and purple dyes. In the field of fragrances, it can be used as an important raw material for the synthesis of certain spices and flavors. 2-Phenylacetamide can also be used in the synthesis of organometallic, organic peroxide, organic peroxide ester, and other compounds, and can be used as a crosslinking agent for polymers, a film forming agent for coatings, a plasticizer for plastics, etc.

Uses

2-Phenylacetamide is used as a pharmaceutical intermediate in the production of penicillin G and phenobarbital, etc. It is also used in organic synthesis.

Definition

ChEBI: 2-phenylacetamide is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It has a role as a mouse metabolite. It derives from a phenylacetic acid.

Preparation

Synthesis of 2-phenylacetamide: Add concentrated hydrochloric acid to phenylacetonitrile, stir to dissolve, and react at 50°C for half an hour. Then slowly add water under cooling to separate out crystals, filter after cooling, wash with ice water to obtain crude product. The crude product was washed with sodium carbonate solution, then washed with ice water, and dried to obtain purer phenylacetamide.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 740, 1953 DOI: 10.1021/ja01099a504
The Journal of Organic Chemistry, 43, p. 402, 1978 DOI: 10.1021/jo00397a005
Organic Syntheses, Coll. Vol. 4, p. 760, 1963

Biological Activity

2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the acetamide repeatedly from absolute EtOH, EtOAc (m 160-161o) or H2O (m 159-160o). Dry it in vacuo over P2O5. [Beilstein 9 H 347, 9 III 2193, 9 IV 1632.]

2-Phenylacetamide Preparation Products And Raw materials

Raw materials

Concentrated hydrochloric acid DimethylamineE Benzyl chloride AMMONIUM POLYSULFIDE Benzeneacetonitrile Activated carbon,decolor Phenylacetic acid

Preparation Products

DIPHACINONE ETHYL A-ETHOXYOXALYLPHENYL ACETATE Ethyl phenylacetate Phenobarbital

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View Lastest Price from 2-Phenylacetamide manufacturers

Forest chemical technology

Product: 2-Phenylacetamide 103-81-1
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 1 ton/year
Release date: 2025-01-15

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2-Phenylacetamide 103-81-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/Week
Release date: 2024-04-30

Hebei Miaoyin Technology Co.,Ltd

Product: 2-Phenylacetamide 103-81-1
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000
Release date: 2023-04-04

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