Valaciclovir
- Product Name
- Valaciclovir
- CAS No.
- 124832-26-4
- Chemical Name
- Valaciclovir
- Synonyms
- VALACYCLOVIR;VALACICLOVIR HYDROCHLORIDE;VALACICLOVIR HCL;VALACV;256U87;Valcivir;VALACICLOVIR;100MG/1G/1KG;Valacyclovir-d4;ValaciclovirBase
- CBNumber
- CB2379191
- Molecular Formula
- C13H20N6O4
- Formula Weight
- 324.34
- MOL File
- 124832-26-4.mol
Valaciclovir Property
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 9.34±0.20(Predicted)
- EPA Substance Registry System
- L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester (124832-26-4)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36
- Hazardous Substances Data
- 124832-26-4(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A3903
- Product name
- Valaciclovir
- Packaging
- 10mg
- Price
- $71
- Updated
- 2021/12/16
- Product number
- A3903
- Product name
- Valaciclovir
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- orb611674
- Product name
- Valacyclovir
- Packaging
- 100mg
- Price
- $277.1
- Updated
- 2021/12/16
- Product number
- orb134346
- Product name
- Valaciclovir HCl
- Purity
- >99%
- Packaging
- 100mg
- Price
- $510
- Updated
- 2021/12/16
- Product number
- orb611674
- Product name
- Valacyclovir
- Packaging
- 1g
- Price
- $615.4
- Updated
- 2021/12/16
Valaciclovir Chemical Properties,Usage,Production
Description
Valaciclovir (also known as BW256U87 or valaciclovir, and marketed under the trade name of Valtrexs by GlaxoSmithKline) is the hydrochloride salt of the L-valyl ester of aciclovir that was developed originally by Wellcome Research Laboratories. This aciclovir prodrug is rapidly and virtually completely converted to aciclovir following oral administration. As oral administration of valaciclovir results in aciclovir plasma levels nearly equivalent to those achieved by intravenous administration, its efficacy is superior to that of oral aciclovir for the treatment of zoster and equivalent to oral aciclovir in the treatment of first and recurrent episodes of genital herpes.
Chemical Properties
White Solid
Originator
Valcivir,Cipla Limited
Uses
The L-Valine ester prodrug of Acyclovir.
Valacyclovir (Valtrex) is the 1-valine ester (prodrug) of acyclovir that exhibits no activity until hydrolyzed in the intestinal wall or liver to acyclovir and its active metabolite. Its modified structure allows increased intestinal absorption and concomitant higher plasma levels of acyclovir. It demonstrates activity against HSV types 1 and 2, varicella-zoster virus, and cytomegalovirus. It exerts its effects by interfering with DNA synthesis through phosphorylation by viral thymidine kinase and subsequent inhibition of viral DNA polymerase, thereby inhibiting viral replication. Valtrex is indicated for the treatment of acute herpes zoster and recurrent genital herpes in immunocompetent adults. The most common side effects are headache, nausea, and vomiting.
Indications
Valacyclovir (Valtrex) is the 1-valine ester (prodrug) of acyclovir that exhibits
no activity until hydrolyzed in the intestinal wall or liver to acyclovir and its
active metabolite. Its modified structure allows increased intestinal absorption
and concomitant higher plasma levels of acyclovir. It demonstrates activity
against HSV types 1 and 2, varicella-zoster virus, and cytomegalovirus.
It exerts its effects by interfering with DNA synthesis through phosphorylation
by viral thymidine kinase and subsequent inhibition of viral DNA
polymerase, thereby inhibiting viral replication. Valtrex is indicated for the
treatment of acute herpes zoster and recurrent genital herpes in immunocompetent
adults. The most common side effects are headache, nausea, and
vomiting.
Valacyclovir is the only antiviral agent approved for herpes labialis,
for a 3-day course in the episodic treatment of recurrent genital herpes (2).
Valacyclovir is indicated for recurrent genital herpes and is administered at
500 mg twice daily for 3 days at the onset of prodromal symptoms or at the first
sign of infection.
Definition
ChEBI: Valacyclovir is a L-valyl ester. It has a role as an antiviral drug. It is functionally related to a guanine.
Manufacturing Process
By dicyclohexylcarbodiimide catalyzed esterification of acyclovir (6H-purin-6- one, 1,9-dihydro-2-amino-9-((2-hydroxyethoxy)methyl)-) with the butyloxycarbonyl valine. Treatment of ester obtained with trifluoroacetic acid leads to scission of the BOC group to provide L-valine ester with 9-((2- hydroxyethoxy)methyl)guanine (valacyclovir).
brand name
Valtrex (GlaxoSmithKline).
Therapeutic Function
Antiviral
Biological Activity
valacyclovir, the metabolic precursor of , is now approved for treatment and prevention of genital infection with herpes simplex viruses [1]. in vitro: vacv uptake was concentration dependent and saturable with a michaelis-menten constant and maximum velocity of 1.64 +/- 0.06 mm and 23.34 +/- 0.36 nmol/mg protein/5 min, respectively. a very similar km value was obtained in hpept1/cho cells and in rat and rabbit tissues and caco-2 cells, suggesting that hpept1 dominates the intestinal transport properties of vacv in vitro [5].
Pharmacology
Valacyclovir (Valtrex), a valine ester prodrug of acyclovir, has a bioavailability three to five times that of acyclovir. This is due to its improved gastrointestinal absorption compared to acyclovir. Valacyclovir is rapidly and almost completely converted to acyclovir after oral administration, with levels comparable to those of intravenous acyclovir. This allows for twice-daily dosing, which may improve compliance and ultimate clinical efficacy. It is more costly than acyclovir.
Clinical Use
Antiviral:
Herpes zoster and simplex
Prevention of cytomegalovirus (CMV) disease after renal transplantation
in vivo
for treatment of a first episode of genital herpes, a large comparative trial has shown that valacyclovir (1 g twice a day) is as effective as acyclovir (200 mg five times a day) when given for 10 days. for treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200 mg five times a day) with a treatment period of 5 days. a daily dose of 1 g of valacyclovir is as effective as 2 g daily. valacyclovir can be administered once a day[1]. the concentrations of acyclovir in serum and csf were measured at steady state after 6 days of oral treatment with 1,000 mg of valacyclovir three times a day [2]. ec50 values of pe and ac in 3t3 cells were 0.02 and 0.01 ug/ml, while values in bhk cells were 0.2 and 0.03 ug/ml. treatment of infected immunosuppressed mice and fa and va (b.i.d., 5.5 days) reduced the proportion with erythema from 100% to 24% and 38%, and eliminated ear paralysis, ear lesions (vesicles, etc) and death. virus was absent from ear and brainstem by day 6, but reappeared after discontinuation in mice treated with va [3].
Drug interactions
Potentially hazardous interactions with other drugs
Ciclosporin: may alter ciclosporin levels; possibly
increased risk of nephrotoxicity.
Mycophenolate: higher concentrations of both
aciclovir and mycophenolic acid on concomitant
administration.
Tacrolimus: possibly increased risk of nephrotoxicity
IC 50
value: 2.9 microg/ml (for hsv-1 w)[4]. valacyclovir, the metabolic precursor of , is now approved for treatment and prevention of genital infection with herpes simplex viruses [1]. in vitro: vacv uptake was concentration dependent and saturable with a michaelis-menten constant and maximum velocity of 1.64 +/- 0.06 mm and 23.34 +/- 0.36 nmol/mg protein/5 min, respectively. a very similar km value was obtained in hpept1/cho cells and in rat and rabbit tissues and caco-2 cells, suggesting that hpept1 dominates the intestinal transport properties of vacv in vitro [5]. in vivo: for treatment of a first episode of genital herpes, a large comparative trial has shown that valacyclovir (1 g twice a day) is as effective as acyclovir (200 mg five times a day) when given for 10 days. for treating recurrences, two trials show that valacyclovir is as effective as acyclovir (200 mg five times a day) with a treatment period of 5 days. a daily dose of 1 g of valacyclovir is as effective as 2 g daily. valacyclovir can be administered once a day[1]. the concentrations of acyclovir in serum and csf were measured at steady state after 6 days of oral treatment with 1,000 mg of valacyclovir three times a day [2]. ec50 values of pe and ac in 3t3 cells were 0.02 and 0.01 ug/ml, while values in bhk cells were 0.2 and 0.03 ug/ml. treatment of infected immunosuppressed mice and fa and va (b.i.d., 5.5 days) reduced the proportion with erythema from 100% to 24% and 38%, and eliminated ear paralysis, ear lesions (vesicles, etc) and death. virus was absent from ear and brainstem by day 6, but reappeared after discontinuation in mice treated with va [3].
Metabolism
Valaciclovir is readily absorbed from the gastrointestinal
tract after oral doses, and is rapidly and almost completely
converted to aciclovir and valine by first-pass intestinal or
hepatic metabolism.
Aciclovir is converted to a small extent to the metabolites
9(carboxymethoxy)methylguanine (CMMG) by alcohol
and aldehyde dehydrogenase and to 8-hydroxy-aciclovir
(8-OH-ACV) by aldehyde oxidase. Approximately 88
%
of the total combined plasma exposure is attributable
to aciclovir, 11
% to CMMG and 1
% to 8-OH-ACV.
Valaciclovir is eliminated mainly as aciclovir and its
metabolite 9- CMMG; less than 1
% of a dose of
valaciclovir is excreted unchanged in the urine.
Toxicity evaluation
In general, the adverse reactions with valaciclovir are similar to those seen with its active metabolite, aciclovir. Preclinical toxicology studies with valaciclovir toxicology studies in animals showed no toxicity separate to that expected from the active metabolite. In a phase 1 study of valaciclovir dosed at either 1 or 2 g four times daily for 30 days, the main reported side-effects were gastrointestinal, with nausea, vomiting, diarrhea, and abdominal pain in up to onethird of patients; no renal or neurologic side-effects were notetoxd, but four patients developed grade 3 or 4 neutropenia. None of the sideeffects observed appeared to be drug related.
Valaciclovir Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Valaciclovir manufacturers
- Product
- Valaciclovir 124832-26-4
- Price
- US $580.00/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 20 TONS
- Release date
- 2022-10-14
- Product
- Valaciclovir 124832-26-4
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-07-19
- Product
- Valacyclovir 124832-26-4
- Price
- US $30.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 20tons
- Release date
- 2021-04-20