Hydrocortisone sodium phosphate

ChemicalBook > CAS DataBase List > Hydrocortisone sodium phosphate

Hydrocortisone sodium phosphate

Product Name: Hydrocortisone sodium phosphate
CAS No.: 6000-74-4
Chemical Name: Hydrocortisone sodium phosphate
Synonyms: Coriphate;Efcortesol;Physiocortison;Hydrocortone phosphate;CORTISOL SODIUM PHOSPHATE;Sodium cortisol 21-phosphate;Hydrocortisone 21-disodium salt;Hydrocortisone phosphate sodium;Hydrocortisone disodium phosphate;SODIUM HYDROCORTISONE-21-PHOSPHATE
CBNumber: CB2397209
Molecular Formula: C21H29O8P.2Na
Formula Weight: 486.41
MOL File: 6000-74-4.mol

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Hydrocortisone sodium phosphate Property

alpha: D25 +120° (H2O)
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS DataBase Reference: 6000-74-4(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H312Harmful in contact with skin

H332Harmful if inhaled

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P314Get medical advice/attention if you feel unwell.

P322Specific measures (see …on this label).

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: H714690
Product name: HydrocortisoneSodiumPhosphate
Packaging: 10g
Price: $1355
Updated: 2021/12/16

AK Scientific

Product number: C870
Product name: Hydrocortisonesodiumphosphate
Packaging: 25mg
Price: $49
Updated: 2021/12/16

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Hydrocortisone sodium phosphate Chemical Properties,Usage,Production

Originator

Corphos,Tilden Yates,US,1959

Uses

Hydrocortisone Sodium Phosphate is the sodium phosphate salt of the corticosteroid Hydrocortisone (H714615).

Definition

ChEBI: An organic sodium salt that is the disodium salt of cortisol phosphate.

Manufacturing Process

21-iodo-11β:17α-dihydroxypregn-4-ene-3,20-dione (5.0 g) in pure acetonitrile (125 ml) was mixed with a solution of 90% phosphoric acid (2.5 ml) and triethylamine (7.5 ml) in acetonitrile (125 ml) and boiled under reflux for 4 hours. The solvent was removed in vacuo and the residue, dissolved in ethanol (20 ml) and water (80 ml), was passed down a column of Zeo-Karb 225 (H+form) (60 g) made up in 20% alcohol. Elution was continued with 20% alcohol (50 ml), 50% alcohol (50 ml) and alcohol (150 ml). The eluate was at first cloudy, but by the end of the elution it was clear and nonacid.
The eluate was titrated to pH 7 with 0.972N NaOH (63 ml). Removal of solvent left a gum, which was boiled with methanol (400 ml) for 20 minutes. The solid insoluble inorganic phosphate was filtered off and washed with methanol (200 ml). The slightly cloudy filtrate was filtered again, and evaporated to dryness in vacuo. The residual gum dissolved readily in water (40 ml) and on addition of acetone (600 ml) to the solution a mixture of sodium salts of hydrocortisone 21-phosphate separated as a white solid. This was collected after 2 days, washed with acetone and dried at 100°C/0.l mm/2 hr to constant weight. Yield 4.45 g.

brand name

Hydrocortone (Merck).

Therapeutic Function

Glucocorticoid

Hydrocortisone sodium phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Hydrocortisone sodium phosphate manufacturers

Hebei Guanlang Biotechnology Co,.LTD

Product: Hydrocortisone Sodium Phosphate 6000-74-4
Price: US $8.00/Kg/Bag
Min. Order: 10g
Purity: 99%
Supply Ability: 10000kg
Release date: 2021-12-21

Zhuozhou Wenxi import and Export Co., Ltd

Product: Hydrocortisone sodium phosphate 6000-74-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Dideu Industries Group Limited

Product: Hydrocortisone sodium phosphate 6000-74-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-11

6000-74-4, Hydrocortisone sodium phosphateRelated Search:

AMPHISOL A Hydrocortisone acetate Triethyl phosphate Tributyl phosphate Ethylenediaminetetraacetic acid disodium salt Hydrocortisone sodium succinate Tylosin phosphate Sodium Phosphate Monobasic Monohydrate Hydrocortisone Hydrocortisone-17-butyrate Trisodium phosphate Hydrocortisone 21-hemisuccinate Sodium Monofluorophosphate phosphate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT CORTEXOLONE MONO-N-DODECYL PHOSPHATE OCTADECYL PHOSPHATE

4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE-21-PHOSPHATE SODIUM SALT

Cortisol 21-phosphate disodium salt (6CI)

Cortisol, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI)

Disodium hydrocortisone 21-phosphate

Efcortesol

Hydrocortisone 21-disodium phosphate

Hydrocortisone 21-disodium salt

Hydrocortisone 21-phosphate disodium

Hydrocortisone 21-phosphate disodium salt

CORTISOL SODIUM PHOSPHATE

SODIUM HYDROCORTISONE-21-PHOSPHATE

hydrocortisone sodium phosphate usp

Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11beta)-

Hydrocortisone 21-sodium phosphate

Hydrocortisone disodium phosphate

Hydrocortone phosphate

Physiocortison

Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11β)-

Sodium cortisol 21-phosphate

(11b)-11,17-Dihydroxy-21-(phosphonooxy)pregn-4-ene-3,20-dione disodium salt

11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(phosphoric acid disodium) salt

Coriphate

Hydrocortisone phosphate sodium

Hydrocortisone Sodium Phosphate RS

Hydrocortisone sodium phosphate USP/EP/BP

HYDROCORTISONE 21-PHOSPHATE SODIUM SALT

4-PREGNEN-11β, 17, 21-TRIOL-3, 20-DIONE-21-PHOSPHATE SODIUM SALT

6000-74-4

C21H29O8PNa2

C21H29O8P2Na

C21H29Na2O8P

Steroids

Steroid and Hormone

Intermediates & Fine Chemicals

Pharmaceuticals