ChemicalBook > CAS DataBase List > Hemin

Hemin

Product Name
Hemin
CAS No.
16009-13-5
Chemical Name
Hemin
Synonyms
HEMIN CHLORIDE;(-)-Syringaresnol-4-O-beta-D-apiofuranos;HEMIN PORCINE;PROTOHEMIN IX;FerriheMe chloride;HEMIN;HAEMIN;Hemin>Hemin,99%;Hemin, USP
CBNumber
CB2409023
Molecular Formula
C34H31ClFeN4O4-
Formula Weight
650.94
MOL File
16009-13-5.mol
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Hemin Property

Melting point:
300 °C
storage temp. 
2-8°C
solubility 
1.4 M NaOH: soluble25mg/mL
form 
crystal
color 
black
Water Solubility 
practically insoluble
Merck 
14,4644
BRN 
5229914
Exposure limits
ACGIH: TWA 1 mg/m3
NIOSH: TWA 1 mg/m3
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey
BTIJJDXEELBZFS-HXFTUNQESA-K
SMILES
[Cl-][Fe+3]123[N-]4C5C(C)=C(C=C)C4=CC4C(C)=C(C=C)C(=CC6=C(C)C(CCC(=O)[O-])=C(C=C7C(CCC(=O)[O-])=C(C)C(C=5)=N17)[N-]26)N3=4.[H+]
EPA Substance Registry System
Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-5-13)- (16009-13-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-22-36-26
WGK Germany 
3
RTECS 
LJ8080000
F 
8
TSCA 
Yes
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P285In case of inadequate ventilation wear respiratory protection.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H9039
Product name
Hemin
Purity
from bovine, ≥90%
Packaging
1g
Price
$64.4
Updated
2024/03/01
Sigma-Aldrich
Product number
51280
Product name
Hemin
Purity
BioXtra, from Porcine, ≥97.0% (HPLC)
Packaging
1g
Price
$74.1
Updated
2024/03/01
Sigma-Aldrich
Product number
51280
Product name
Hemin
Purity
BioXtra, from Porcine, ≥97.0% (HPLC)
Packaging
5g
Price
$272
Updated
2024/03/01
Sigma-Aldrich
Product number
3741
Product name
Hemin Chloride - CAS 16009-13-5 - Calbiochem
Packaging
5G
Price
$143
Updated
2024/03/01
Alfa Aesar
Product number
A11165
Product name
Hemin (porcine), 97+%
Packaging
1g
Price
$49.7
Updated
2023/06/20
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Hemin Chemical Properties,Usage,Production

Description

Hemin is a metalloporphyrin compound with a relatively simple structure. It is formed by the complexation of a molecule of ferrous iron and protoporphyrin. It is an in vitro group substitute of natural heme and its chemical properties are similar to that of heme. Heme, an essential small molecule in living organisms, can be found abundantly in various organisms including animals, plants, microorganisms, and algae.

Chemical Properties

Hemin is a Dark purple crystalline powder or elongated needle-shaped crystal. It does not dissolve in water, but it can dissolve in acidic acetone and alkaline water. The molecular formula is C34H32ClFe(III)N4O4, and the molecular weight is 651.96. Hemin is mainly used as raw material for anti-anemia and anti-cancer drugs.

Application

Hemin is used for the following applications:
To study bacterial strains and growth conditions
Used in short-term colony assays (the culture medium consists of hemin along with other components)
Cell transfections
It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.

Uses

Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addition, it is used in the preparation of agar medium for the bacteria culture.

General Description

Heme is a small molecule present either free or bound to hemoglobin in the bloodstream of mammals. This is an alternative source of iron within the host that contains a porphyrin ring containing a Fe2+ ion called hemin.

Biochem/physiol Actions

Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.

Purification Methods

Hemin is purified by recrystallisation from AcOH. Also, hemin (5g) is shaken in pyridine (25mL) till it dissolves, then CHCl3 (40mL) is added, the container is stoppered and shaken for 5minutes (releasing the stopper occasionally). The solution is filtered under slight suction, and the flask and filter are washed with a little CHCl3 (15mL). During this period, AcOH (300mL) is heated to boiling, and saturated aqueous NaCl (5mL) and conc HCl (4mL) are added. The CHCl3 filtrate is poured in a steady stream, with stirring, into the hot AcOH mixture and set aside for 12hours. The crystals are filtered off, washed with 50% aqueous AcOH (50mL), H2O (100mL), EtOH (25mL), Et2O and dried in air. [Fischer Org Synth Coll Vol III 442 1955, Beilstein 26 III/IV 3048.]

Hemin Preparation Products And Raw materials

Raw materials

Cellulose-DEAE，DE 32 Diethylamine Dichloroacetic acid Strontium chloride

Preparation Products

Hematoprophyrin HEMATOPORPHYRIN
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Hemin Suppliers

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View Lastest Price from Hemin manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Hemin 16009-13-5
Price
US $635.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2021-06-03
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Hemin 16009-13-5
Price
US $990.00-800.00/g
Min. Order
1g
Purity
99%
Supply Ability
5000
Release date
2024-08-19
Shanghai Affida new material science and technology center
Product
Hematin chloride；Hemin；Hematine hydrochloride 16009-13-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99
Supply Ability
10 tons
Release date
2024-04-26

16009-13-5, HeminRelated Search:

Iron saccharate PHYTOHEMAGGLUTININ PHA-M Hematin Bethanechol Allylacetic acid 2,3,4,5-TETRAMETHYLPYRROLE Allylamine hydrochloride 4-HEXENOIC ACID 6-Heptenoic acid 3-BUTEN-1-AMINE 2,5-Dimethyl-1H-pyrrole 2,4-Dimethylpyrrole PROTOPORPHYRIN IX DIMETHYL ESTER FROM*OX HEMIN BOVINE HEMIN Hemin (Ferriprotoporphyrin IX chloride), min. 95%,HEMIN (FERRIPROTOPORPHYRIN IX CHLORIDE), MIN. 95,Hemin (Ferriprotoporphyrin IX chloride) PORPHINE Protoporphyrin IX Difluorochloromethane

  • PROTOHEMIN IX
  • HEMATIN HYDROCHLORIDE
  • HEMIN
  • HEMIN, BOVINE
  • HEMIN CHLORIDE
  • HEMIN CHLORIDE BOVINE
  • HEMIN CHLORIDE PORCINE
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  • HEMIN PORCINE
  • HAEMIN
  • FERRIPROTOPORPHRIN IX CHLORIDE
  • FERRIPROTOPORPHYRIN IX CHLORIDE
  • CHLOROHEMIN
  • CHLOROFERRIPROTOPORPHYRIN
  • CHLORO(PROTOPORPHYRINATO)IRON(III)
  • CHLOROPROTOPORPHYRIN IX IRON(III)
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  • Hemin from Bovine
  • HEMIN, BIOXTRA, FROM PORCINE, >=97.0
  • Chlorohemin Chloroprotoporphyrin IX iron(III)
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  • HEMIN, BOVINE MOLECULAR BIOLOGY GRADE 99%
  • HEMIN, PORCINE 90% WATER SOLUABLE
  • HEMIN, PORCINE 98% PHARMACEUTICAL & BIOTECH GRADE
  • HEMIN, BOVINE 98+%
  • Hemin from porcine blood
  • Ferrate(2-), chloro7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24-, dihydrogen, (SP-5-13)-
  • HEMIN,BOVINE,CRYSTAL
  • chlorido(protoporphyrinato)iron(III)
  • Hematin chloride
  • Haemin,Crystalline
  • Ferrate(2-), chloro[7,12-diethenyl-3,8, 13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato (4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-
  • HEMIN ULTRA-PURE
  • Hemin (from porcine)
  • Hemin, 98+%
  • Dihydrogen (SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-ferrate(2-)
  • Chloro(protoporphyrinato)iron(III), Chlorohemin, Chloroprotoporphyrin IX iron(III), Ferriprotoporphyrin IX chloride, Hemin(chloride)
  • Ferrate(2-),chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]-, hydrogen (1:2), (SP-5-13)-
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  • Hemin Chloride - CAS 16009-13-5 - Calbiochem
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  • HEMIN CRYST.RESEARCH GRADE
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  • Chlorhaematin
  • 1,3,5,8-TetraMethy1-2,4-divinylporphine-6,7-dipropionic acid ferrichloride
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  • HEMIN BOVINE, MINIMUM 80%
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  • Ferriprotoporphyrine IX chloride, Hemin chloride