ChemicalBook > CAS DataBase List > Hemin

Hemin

Product Name: Hemin
CAS No.: 16009-13-5
Chemical Name: Hemin
Synonyms: HEMIN CHLORIDE;(-)-Syringaresnol-4-O-beta-D-apiofuranos;HEMIN PORCINE;PROTOHEMIN IX;FerriheMe chloride;HEMIN;HAEMIN;Hemin>Hemin,99%;Hemin, USP
CBNumber: CB2409023
Molecular Formula: C34H31ClFeN4O4-
Formula Weight: 650.94
MOL File: 16009-13-5.mol

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Hemin Property

Melting point:: 300 °C
storage temp.: 2-8°C
solubility: 1.4 M NaOH: soluble25mg/mL
form: crystal
color: black
biological source: Porcine
Water Solubility: practically insoluble
Merck: 14,4644
BRN: 5229914
Exposure limits: ACGIH: TWA 1 mg/m3
NIOSH: TWA 1 mg/m3
Stability:: Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey: BTIJJDXEELBZFS-HXFTUNQESA-K
SMILES: [Cl-][Fe+3]123[N-]4C5C(C)=C(C=C)C4=CC4C(C)=C(C=C)C(=CC6=C(C)C(CCC(=O)[O-])=C(C=C7C(CCC(=O)[O-])=C(C)C(C=5)=N17)[N-]26)N3=4.[H+]
EPA Substance Registry System: Ferrate(2-), chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-5-13)- (16009-13-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-22-36-26
WGK Germany: 3
RTECS: LJ8080000
F: 8
TSCA: Yes
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P285In case of inadequate ventilation wear respiratory protection.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H9039
Product name: Hemin
Purity: from bovine, ≥90%
Packaging: 1g
Price: $66
Updated: 2025/07/31

Sigma-Aldrich

Product number: 51280
Product name: Hemin
Purity: BioXtra, from Porcine, ≥97.0% (HPLC)
Packaging: 1g
Price: $78.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 51280
Product name: Hemin
Purity: BioXtra, from Porcine, ≥97.0% (HPLC)
Packaging: 5g
Price: $289
Updated: 2025/07/31

Sigma-Aldrich

Product number: 3741
Product name: Hemin Chloride - CAS 16009-13-5 - Calbiochem
Packaging: 5G
Price: $147
Updated: 2025/07/31

Cayman Chemical

Product number: 16487
Product name: Hemin chloride
Purity: ≥96%
Packaging: 1g
Price: $49
Updated: 2024/03/01

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Hemin Chemical Properties,Usage,Production

Description

Hemin is a metalloporphyrin compound with a relatively simple structure. It is formed by the complexation of a molecule of ferrous iron and protoporphyrin. It is an in vitro group substitute of natural heme and its chemical properties are similar to that of heme. Heme, an essential small molecule in living organisms, can be found abundantly in various organisms including animals, plants, microorganisms, and algae.

Chemical Properties

Hemin is a Dark purple crystalline powder or elongated needle-shaped crystal. It does not dissolve in water, but it can dissolve in acidic acetone and alkaline water. The molecular formula is C34H32ClFe(III)N4O4, and the molecular weight is 651.96. Hemin is mainly used as raw material for anti-anemia and anti-cancer drugs.

Application

Hemin is used for the following applications:
To study bacterial strains and growth conditions
Used in short-term colony assays (the culture medium consists of hemin along with other components)
Cell transfections
It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.

Uses

Hemin is used in cellular protection and control mechanism. It stimulates the synthesis of globulin. It is also used to study the bacterial strains and growth conditions, in the short-term colony assays and cell transfections. Further, it is used to treat the symptoms of various porphyrias. In addition, it is used in the preparation of agar medium for the bacteria culture.

General Description

Heme is a small molecule present either free or bound to hemoglobin in the bloodstream of mammals. This is an alternative source of iron within the host that contains a porphyrin ring containing a Fe²⁺ ion called hemin.

Biochem/physiol Actions

Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.

Purification Methods

Hemin is purified by recrystallisation from AcOH. Also, hemin (5g) is shaken in pyridine (25mL) till it dissolves, then CHCl3 (40mL) is added, the container is stoppered and shaken for 5minutes (releasing the stopper occasionally). The solution is filtered under slight suction, and the flask and filter are washed with a little CHCl3 (15mL). During this period, AcOH (300mL) is heated to boiling, and saturated aqueous NaCl (5mL) and conc HCl (4mL) are added. The CHCl3 filtrate is poured in a steady stream, with stirring, into the hot AcOH mixture and set aside for 12hours. The crystals are filtered off, washed with 50% aqueous AcOH (50mL), H2O (100mL), EtOH (25mL), Et2O and dried in air. [Fischer Org Synth Coll Vol III 442 1955, Beilstein 26 III/IV 3048.]

Hemin Preparation Products And Raw materials

Raw materials

Cellulose-DEAE，DE 32 Diethylamine Dichloroacetic acid Strontium chloride

Preparation Products

Hematoprophyrin HEMATOPORPHYRIN

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View Lastest Price from Hemin manufacturers

RongNa Biotechnology Co.,Ltd

Product: Hemin 16009-13-5
Price: US $1.00/g
Min. Order: 1g
Purity: 0.99
Supply Ability: 20 tons
Release date: 2025-06-02

Hebei Chuanghai Biotechnology Co., Ltd

Product: Hemin 16009-13-5
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-29

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Hemin 16009-13-5
Price: US $990.00-800.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-19

16009-13-5, HeminRelated Search:

Iron saccharate PHYTOHEMAGGLUTININ PHA-M Hematin Bethanechol Allylacetic acid 2,3,4,5-TETRAMETHYLPYRROLE Allylamine hydrochloride 4-HEXENOIC ACID 6-Heptenoic acid 3-BUTEN-1-AMINE 2,5-Dimethyl-1H-pyrrole 2,4-Dimethylpyrrole PROTOPORPHYRIN IX DIMETHYL ESTER FROM*OX HEMIN BOVINE HEMIN Hemin (Ferriprotoporphyrin IX chloride), min. 95%,HEMIN (FERRIPROTOPORPHYRIN IX CHLORIDE), MIN. 95,Hemin (Ferriprotoporphyrin IX chloride) PORPHINE Protoporphyrin IX Difluorochloromethane

PROTOHEMIN IX

HEMATIN HYDROCHLORIDE

HEMIN

HEMIN, BOVINE

HEMIN CHLORIDE

HEMIN CHLORIDE BOVINE

HEMIN CHLORIDE PORCINE

HEMIN (EX PORCINE, BOVINE, EQUINE)

HEMIN PORCINE

HAEMIN

FERRIPROTOPORPHRIN IX CHLORIDE

FERRIPROTOPORPHYRIN IX CHLORIDE

CHLOROHEMIN

CHLOROFERRIPROTOPORPHYRIN

CHLORO(PROTOPORPHYRINATO)IRON(III)

CHLOROPROTOPORPHYRIN IX IRON(III)

EQUINE HEMIN

12-diethenyl-3,8,13,17-tetramethyl-21h,23h-porphine-2,18-ferrate(2-chloro[7

Hemin from Bovine

HEMIN, BIOXTRA, FROM PORCINE, >=97.0

Chlorohemin Chloroprotoporphyrin IX iron(III)

Hemin, USP

HEMIN, BOVINE MOLECULAR BIOLOGY GRADE 99%

HEMIN, PORCINE 90% WATER SOLUABLE

HEMIN, PORCINE 98% PHARMACEUTICAL & BIOTECH GRADE

HEMIN, BOVINE 98+%

Hemin from porcine blood

Ferrate(2-), chloro7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24-, dihydrogen, (SP-5-13)-

HEMIN,BOVINE,CRYSTAL

chlorido(protoporphyrinato)iron(III)

Hematin chloride

Haemin,Crystalline

Ferrate(2-), chloro[7,12-diethenyl-3,8, 13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato (4-)-N21,N22,N23,N24]-, dihydrogen, (SP-5-13)-

HEMIN ULTRA-PURE

Hemin (from porcine)

Hemin, 98+%

Dihydrogen (SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-ferrate(2-)

Chloro(protoporphyrinato)iron(III), Chlorohemin, Chloroprotoporphyrin IX iron(III), Ferriprotoporphyrin IX chloride, Hemin(chloride)

Ferrate(2-),chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kN21,kN22,kN23,kN24]-, hydrogen (1:2), (SP-5-13)-

Chlorohemin, Bovine

Hemin Chloride - CAS 16009-13-5 - Calbiochem

Hemin In stock Factory

Hemin, ≥95%

n22,n23,n24]-,dihydrogen,(sp-5-13)-dipropanoato(4-)-n2

Hemin, bovine (crystalline),98%

Hemin,99%

Ferriprotoporphyrine IV Cloride

HEMIN CRYST.RESEARCH GRADE

Hemin,Chloro(protoporphyrinato)iron(III), Chlorohemin, Chloroprotoporphyrin IX iron(III), Ferriprotoporphyrin IX chloride, Hemin(chloride)

Chlorhaematin

1,3,5,8-TetraMethy1-2,4-divinylporphine-6,7-dipropionic acid ferrichloride

FerriheMe chloride

Ferriporphyr in chloride

HeMatine hydrochloride

HEMIN BOVINE, MINIMUM 80%

ChloroprotoferriheM

HeMin (porcine), 98+%

Ferriprotoporphyrine IX chloride, Hemin chloride