Naphazoline
- Product Name
- Naphazoline
- CAS No.
- 835-31-4
- Chemical Name
- Naphazoline
- Synonyms
- NAPHAZOLINE HCL;Naphazoline-d4;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE;Antan;Imidin;Privine;Sanorin;Rhinazine;NAFAZOLINE;ciba2020/r
- CBNumber
- CB2414016
- Molecular Formula
- C14H14N2
- Formula Weight
- 210.27
- MOL File
- 835-31-4.mol
Naphazoline Property
- Melting point:
- 254 °C
- Boiling point:
- 339.81°C (rough estimate)
- Density
- 1.1063 (rough estimate)
- refractive index
- 1.6180 (estimate)
- storage temp.
- 2-8°C
- pka
- pKa 10.35 ± 0.02(H2O,t =25,Iundefined) (Uncertain)
- CAS DataBase Reference
- 835-31-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Naphazoline(835-31-4)
N-Bromosuccinimide Price
- Product number
- RDL0006964
- Product name
- NAPHAZOLINE-D4
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.33
- Updated
- 2021/12/16
- Product number
- CM128968
- Product name
- 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $259
- Updated
- 2021/12/16
- Product number
- CD33000071
- Product name
- Naphazoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $274
- Updated
- 2021/12/16
Naphazoline Chemical Properties,Usage,Production
Originator
Privine,Ciba,US,1942
Uses
Naphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe and chronic inflammatory conditions, in particular for inflammation of the antrum of Highmore as well as for stopping nosebleeds.
Uses
Adrenergic (vasoconstrictor).
Definition
ChEBI: 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.
Manufacturing Process
2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula (produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and simultaneously stirring until ammonia escapes no longer. The alcohol is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring is continued for some time whereby the imidazoline base is dissolved in benzene. The benzene residue is recrystallized several times from toluene.
brand name
Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).
Therapeutic Function
Nasal decongestant
Synthesis
Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline derivative (11.1.36) upon reaction with ethylendiamine [40].
Naphazoline Preparation Products And Raw materials
Raw materials
Preparation Products
Naphazoline Suppliers
- Tel
- --
- Fax
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- enquiry@leancare.co.uk
- Country
- United Kingdom
- ProdList
- 6446
- Advantage
- 42
- Tel
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- Fax
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- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
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- Tel
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- Country
- United Kingdom
- ProdList
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- Advantage
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- Tel
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- Fax
- --
- sheila@mda-chem.co.uk
- Country
- United Kingdom
- ProdList
- 1961
- Advantage
- 30
View Lastest Price from Naphazoline manufacturers
- Product
- naphazoline 835-31-4
- Price
- US $50.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500tons/month
- Release date
- 2021-08-30
- Product
- Naphazoline 835-31-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2020-03-05
- Product
- Naphazoline 835-31-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03