Glycidyl phenyl ether Property

Melting point:

3.5 °C(lit.)

Boiling point:

245-247 °C(lit.)

Density 

1.109 g/mL at 25 °C(lit.)

vapor density 

5.2 (vs air)

vapor pressure 

0.03 mm Hg ( 20 °C)

refractive index 

n20/D 1.531

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

2.4g/l

form 

Liquid

color 

Clear colorless to yellow

Water Solubility 

2.4 g/L (20 ºC)

BRN 

2744

Exposure limits

TLV-TWA 6 mg/m³ (1 ppm) (ACGIH); 1 ppm (15 min) (NIOSH).

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

FQYUMYWMJTYZTK-UHFFFAOYSA-N

LogP

1.61 at 25℃

CAS DataBase Reference

122-60-1(CAS DataBase Reference)

NIST Chemistry Reference

Oxirane, (phenoxymethyl)-(122-60-1)

IARC

2B (Vol. 47, 71) 1999

EPA Substance Registry System

Phenyl glycidyl ether (122-60-1)

Safety

Hazard Codes 

T

Risk Statements 

45-20-37/38-43-52/53-68

Safety Statements 

53-45-61

OEL

Ceiling: 1 ppm (6 mg/m3) [15-minute]

RIDADR 

2810

WGK Germany 

3

RTECS 

TZ3675000

Autoignition Temperature

430 °C

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29109000

Hazardous Substances Data

122-60-1(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 2150 mg/kg LD50 dermal Rabbit 1500 mg/kg

IDLA

100 ppm

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H332Harmful if inhaled

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H350May cause cancer

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

Glycidyl phenyl ether Chemical Properties,Usage,Production

Chemical Properties

Phenyl glycidyl ether, also known as glycidyl phenyl ether or PGE, is a clear liquid with a sweet odor that is considered unpleasant. It is soluble in ether and benzene, but insoluble in water. It has the ability to volatilize with water vapor. It is used in the production of epoxy resins, as a chemical intermediate, and as a stabilizer.

Uses

Phenyl glycidyl ether (PGE) is utilized in organic syntheses as an intermediate. As a reactive diluent, PGE is incorporated into uncured epoxy resins to lower viscosity, thereby facilitating casting, adhesives, and laminating applications.

Uses

2-Phenylglycidyl ether is an organic synthesis; chemical intermediate with high solvency for halogenated materials; reactive diluent of epoxy-resin systems; forms chemical bonds with the resin during cure and accelerates the curing process.

Definition

ChEBI: Phenyl glycidyl ether is an aromatic ether.

Production Methods

PGE is synthesized by condensation of phenol with epichlorohydrin, with subsequent dehydrochlorination with caustic to form the epoxy ring.

Synthesis Reference(s)

The Journal of Organic Chemistry, 50, p. 1784, 1985 DOI: 10.1021/jo00210a053

General Description

Colorless liquid.

Air & Water Reactions

Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Slightly soluble in water.

Reactivity Profile

Glycidyl phenyl ether, an ether, can act as a base. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Health Hazard

PGE is a toxic compound exhibiting moderate irritant action and carcinogenicity inanimals. Application of 0.25 mg resulted insevere eye irritation in rabbits, while 500 mgcaused moderate skin irritation over a periodof 24 hours. Prolonged or repeated contactcan cause moderate irritation and skin sensitization in humans.
The symptoms of its toxicity in animalswere depression of the central nervous system and paralysis of the respiratory tract.Prolonged exposure caused changes in thekidney, liver, thymus, and testes, and lossof hair in rats. The toxicity of this compound in humans is low and the health hazardcan arise primarily from its skin-sensitizationaction.
LD50 value, oral (mice): 1400 mg/kg
DGE showed carcinogenicity in rats, causingnasal cancer.

Fire Hazard

Glycidyl phenyl ether is probably combustible.

Contact allergens

This monoglycidyl derivative is a reactive diluent in epoxy resins Bisphenol A type. It is a component of epoxy paints, epoxy glues, and epoxy resins. Sensitization has been observed in many professions, such as in construction workers, marble workers, ceramic workers, and shoemakers.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion, skin contact, and subcutaneous routes. A severe eye and skin irritant. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a chemical intermediate. See also ETHERS

Potential Exposure

PGE is used to increase storage time and stability of halogenated compounds; as a reactive diluent in uncured epoxy resins to reduce the viscosity of the uncured system for ease in casting; adhesive, and laminating applications. NIOSH once estimated that 8000 workers are potentially exposed to PGE.

Carcinogenicity

Chronic exposure of rats to 1 or 12ppm 6 hours/day, 5 days/week for 2 years caused an increased incidence of rhinitis, squamous metaplasia, and epidermal carcinomas of the nasal cavity.4 The IARC has determined that there is sufficient evidence for the carcinogenicity of PGE in animals and that it is possibly carcinogenic to humans.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, amines, and curing agents. PGE can presumably form explosive peroxides

Waste Disposal

Concentrated waste containing no peroxides-discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxidesperforation of a container of the waste from a safe distance followed by open burning.