ChemicalBook > CAS DataBase List > PROSTAGLANDIN D2

PROSTAGLANDIN D2

Product Name: PROSTAGLANDIN D2
CAS No.: 41598-07-6
Chemical Name: PROSTAGLANDIN D2
Synonyms: PGDS;PGD2;Prostaglandin D?;PROSTAGLANDIN D2;PROSTAGLANDINS D2;PGD2 (Prostaglandin D2);RP23-47P18.11-006, 21kDa;Prostaglandin D₂;11-dehydroprostaglandinf2-alpha;Prostaglandin D2 MaxSpecStandard
CBNumber: CB2433095
Molecular Formula: C20H32O5
Formula Weight: 352.47
MOL File: 41598-07-6.mol

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PROSTAGLANDIN D2 Property

Melting point:: 68°C
Boiling point:: 406.07°C (rough estimate)
alpha: +7.5°(D/21℃)(c=1,THF)
Density: 1.0601 (rough estimate)
refractive index: 1.6120 (estimate)
storage temp.: -20°C
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly), THF (Slightly)
pka: 4.76±0.10(Predicted)
form: White solid
color: White to Light Orange
biological source: synthetic
BRN: 2170623
Stability:: Light Sensitive

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Safety

Hazard Codes: T
Risk Statements: 60-22
Safety Statements: 53-22-26-36
WGK Germany: 3
RTECS: UK7930000
F: 10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P5172
Product name: Prostaglandin D2
Purity: ≥95%, synthetic
Packaging: 1mg
Price: $195.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: SAB2502046
Product name: Anti-Ptgds antibody produced in goat
Purity: affinity isolated antibody, buffered aqueous solution
Packaging: 100μG
Price: $586
Updated: 2025/07/31

Sigma-Aldrich

Product number: 538909
Product name: Prostaglandin D?
Packaging: 1mg
Price: $196
Updated: 2025/07/31

Cayman Chemical

Product number: 12010
Product name: Prostaglandin D2
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 12010
Product name: Prostaglandin D2
Purity: ≥98%
Packaging: 5mg
Price: $216
Updated: 2024/03/01

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PROSTAGLANDIN D2 Chemical Properties,Usage,Production

Description

Prostaglandin D₂ (PGD₂) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD₂ is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace. In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD₂ inhibits human ovarian tumor cell proliferation with an IC₅₀ of 6.8 μM.

Uses

Prostaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma.

Definition

ChEBI: A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- s ereoisomer).

Biochem/physiol Actions

Primary prostaglandin in brain; induces inflammation; stimulates adenylyl cyclase.

in vivo

Prostaglandin D2 (PGD2; infused into the lateral ventricle; 5-50 pmol/min; for 6 hours between 20:00 and 2:00) induces sleep-wake profiles in A2AR KO mice^[2].

Animal Model:	Male WT and A2AR KO mice of the inbred C57BL/6 strain (weighing 23-27 g, 11-13 weeks old)^[1]
Dosage:	5, 10, 20, or 50 pmol/min
Administration:	Infused into the lateral ventricle; for 6 hours between 20:00 and 2:00
Result:	Induced sleep-wake profiles.

IC 50

DP; Human Endogenous Metabolite

References

[1] L.JACKSON ROBERTS II Brian J S. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis[J]. Prostaglandins, 1985, 30 3: Pages 383-400. DOI: 10.1016/0090-6980(85)90114-5
[2] HAYAISHI O. Sleep-wake regulation by prostaglandins D2 and E2.[J]. The Journal of Biological Chemistry, 1988, 263 29: 14593-14596.
[3] H ONOE. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1988, 85 11: 4082-4086. DOI: 10.1073/pnas.85.11.4082
[4] Y KIKUCHI. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells.[J]. Cancer and Metastasis Reviews, 1994, 13 3-4: 309-315. DOI: 10.1007/bf00666101
[5] BRENDAN J. WHITTLE . Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: Treprostinil is a potent DP1 and EP2 agonist[J]. Biochemical pharmacology, 2012, 84 1: Pages 68-75. DOI: 10.1016/j.bcp.2012.03.012
[6] OYEBOLA O OYESOLA. The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung.[J]. Journal of immunology, 2020, 204 4: 1001-1011. DOI: 10.4049/jimmunol.1900745
[7] AKIKO SUGANAMI. Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands[J]. The FEBS journal, 2016, 283 21: 3931-3940. DOI: 10.1111/febs.13899
[8] D F WOODWARD. Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024).[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 305 2: 772-785. DOI: 10.1124/jpet.102.047837
[9] P. WAFFO-TéGUO. Potential Cancer-Chemopreventive Activities of Wine Stilbenoids and Flavans Extracted From Grape (Vitis vinifera) Cell Cultures[J]. Nutrition and Cancer-An International Journal, 2001, 40 1: 173-179. DOI: 10.1207/s15327914nc402_14

PROSTAGLANDIN D2 Preparation Products And Raw materials

Raw materials

Preparation Products

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41598-07-6, PROSTAGLANDIN D2Related Search:

Latanoprost Lactol Fluprostenol PROSTAGLANDIN D2 Prostaglandin E1 Latanoprost PROSTAGLANDIN G2 PROSTAGLANDIN H1 Latanoprost acid ENPROSTIL PROSTAGLANDIN J2 PROSTAGLANDIN B2 Inositol Prostaglandin E2 PROSTAGLANDIN A2 PROSTAGLANDIN A1 Latanoprost Lactone Diol Carboprost Acid Red 94

9,15-dihydroxy-11-oxo-,(5z,9-alpha,13e,15s)-prosta-13-dien-1-oicacid

prostaglandin D2 cell culture tested

prostaglandind2synthetichygroscopic

(5z,9α,13e,15s)-9,15-dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid

7-[(1R,2R,5S)-5-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid

PGD2, (5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid

(5Z,13E,15S)-9α,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid

Prostaglandin D2,(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid, PGD2

Prostaglandin D2 Lipid Maps MS Standard

(Z)-7-((1R,2R,5S)-5-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-3-oxocyclopentyl)hept-5-enoic acid

Anti-Ptgds antibody produced in goat

PGDS

prostaglandin D2 synthase (brain)

RP23-47P18.11-006, 21kDa

PGD2 (Prostaglandin D2)

Prostaglandin D?

PROSTAGLANDIN D2

PROSTAGLANDINS D2

PGD2

9ALPHA,15S-DIHYDROXY-11-OXO-PROSTA-5Z,13E-DIEN-1-OIC ACID

[5Z,9ALPHA,13E,15S]9,15-DIHYDROXY-11-OXOPROSTA-5,13-DIEN-1-OIC ACID

11-dehydroprostaglandinf2-alpha

Prostaglandin D2 MaxSpecStandard

Prostaglandin D - CAS 41598-07-6 - Calbiochem

Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15S)-

Prostaglandin D2, HDP1 and CRTH2 receptor agonist

Prostaglandin D<sub>2</sub>

41598-07-6

Fatty Acids

Prostaglandins

Lipids

BioChemical

Biochemicals and Reagents