PROSTAGLANDIN D2 Property

Melting point:

68°C

Boiling point:

406.07°C (rough estimate)

alpha 

+7.5°(D/21℃)(c=1,THF)

Density 

1.0601 (rough estimate)

refractive index 

1.6120 (estimate)

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly), THF (Slightly)

pka

4.76±0.10(Predicted)

form 

White solid

color 

White to Light Orange

BRN 

2170623

Stability:

Light Sensitive

Safety

Hazard Codes 

T

Risk Statements 

60-22

Safety Statements 

53-22-26-36

WGK Germany 

3

RTECS 

UK7930000

F 

10

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

PROSTAGLANDIN D2 Chemical Properties,Usage,Production

Description

Prostaglandin D₂ (PGD₂) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD₂, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD₂ is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace. In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD₂ inhibits human ovarian tumor cell proliferation with an IC₅₀ of 6.8 μM.

Uses

Prostaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma.

Definition

ChEBI: A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- s ereoisomer).

Biochem/physiol Actions

Primary prostaglandin in brain; induces inflammation; stimulates adenylyl cyclase.