Cytidine 5'-monophosphate disodium salt
Uses- Product Name
- Cytidine 5'-monophosphate disodium salt
- CAS No.
- 6757-06-8
- Chemical Name
- Cytidine 5'-monophosphate disodium salt
- Synonyms
- CMP-2Na;CMP, NA2;5'-CMP 2NA;5'-cmp-na2;C-5μ-P, CMP;CMP DISODIUM SALT;C-5'-P DISODIUM SALT;Cytidine 5'-monophos;Guanosine 5'-cytidine;Disodium 5’-cytidylate
- CBNumber
- CB2441544
- Molecular Formula
- C9H15N3NaO8P
- Formula Weight
- 347.2
- MOL File
- 6757-06-8.mol
Cytidine 5'-monophosphate disodium salt Property
- Melting point:
- 300 °C
- refractive index
- 8 ° (C=2, H2O)
- storage temp.
- 2-8°C
- form
- crystalline
- color
- White
- InChI
- InChI=1/C9H14N3O8P.Na.H/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3
- InChIKey
- RCIPNLSOCXMZDD-RFFBCSJBNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(N)=NC1=O)O.[NaH] |&1:1,2,3,11,r|
- CAS DataBase Reference
- 6757-06-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-24/25-37/39-36-26
- WGK Germany
- 3
- F
- 1-10
- HS Code
- 29349990
N-Bromosuccinimide Price
- Product number
- C1006
- Product name
- Cytidine 5′-monophosphate disodium salt
- Purity
- Sigma Grade, ≥99%, crystalline
- Packaging
- 500MG
- Price
- $48.9
- Updated
- 2023/06/20
- Product number
- C1006
- Product name
- Cytidine 5′-monophosphate disodium salt
- Purity
- Sigma Grade, ≥99%, crystalline
- Packaging
- 1G
- Price
- $59.3
- Updated
- 2023/06/20
- Product number
- C1006
- Product name
- Cytidine 5′-monophosphate disodium salt
- Purity
- Sigma Grade, ≥99%, crystalline
- Packaging
- 5G
- Price
- $159
- Updated
- 2023/06/20
- Product number
- C0524
- Product name
- Cytidine 5'-Monophosphate Disodium Salt Hydrate
- Purity
- >99.0%(HPLC)
- Packaging
- 1g
- Price
- $17
- Updated
- 2024/03/01
- Product number
- C0524
- Product name
- Cytidine 5'-Monophosphate Disodium Salt Hydrate
- Purity
- >99.0%(HPLC)
- Packaging
- 5g
- Price
- $26
- Updated
- 2024/03/01
Cytidine 5'-monophosphate disodium salt Chemical Properties,Usage,Production
Uses
Cytidine 5'-Monophosphate Disodium Salt is a salt form of Cytidine 5'-Monophosphate, a constituent of nucleic acids that has been isolated from yeast nucleic acid.
Description
Cytidine 5'-monophosphate disodium salt (5'-CMPNa2) is an organic sodium salt that can be used as a pharmaceutical active ingredient. 5'-CMPNa2 can be used with UMP-Na2, vitamin B6, lipoic acid, and magnesium lactate dihydrate to prepare a capsule-type compound drug for the treatment of polyneuropathy[1].
Chemical Properties
White crystalline powder
Uses
Cytidine 5′-monophosphate disodium salt has been used:
- in nucleotide stock solution
- as an ectonucleotidase (ENTase) inhibitor to probe 5′-ENTase activity in cortical neurons
- in in vitro studies to estimate its effect on growth response of selected bacteria strains that dominate the piglets′ small intestine
Production Methods
The production method of Cytidine 5'-monophosphate disodium salt comprises the following steps: a. adding cytidine, triethyl phosphate and pyridine into a reaction container respectively, and adjusting the reaction temperature to -15-5°C after mixing evenly, and slowly adding a certain amount of phosphorus oxychloride under the temperature condition, and continuing to stir and react for 10-30h after adding; b. taking samples for HPLC analysis, and when the conversion rate is ≥99%, adding 10-15% ice salt water for hydrolysis, and the hydrolysis temperature is controlled to be 0-5°C, and the hydrolysis time is 10-20h; c. after the hydrolysis is completed, standing and stratifying, removing the organic phase, and obtaining a water layer for standby use; d. adjusting the pH of the water layer to 7.0-8.0 with 30% sodium hydroxide, and then dripping 95% alcohol twice the volume of the solution, precipitating crystals, and filtering to obtain a crude product. e. dissolving the crude product, adding activated carbon for decolorization, and continuing to drip 95% alcohol twice the volume of the solution to precipitate crystals, filtering, rinsing, and drying to obtain the finished product Cytidine 5'-monophosphate disodium salt.
Definition
ChEBI: An organic sodium salt that is the disodium salt of CMP.
Biochem/physiol Actions
Cytidine monophosphate?(CMP) serve as a nucleotide?carrier for sugars.
References
[1] M. ALMAKAIEV L. S O Bashura. The risk assessment of the combined medicine in the capsule dosage form at the pharmaceutical development stage[J]. News of Pharmacy, 2021. DOI:10.24959/nphj.21.54.
Cytidine 5'-monophosphate disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
Cytidine 5'-monophosphate disodium salt Suppliers
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
- Tel
- --
- Fax
- --
- sales@chemcube.eu
- Country
- Germany
- ProdList
- 4083
- Advantage
- 34
- Tel
- --
- Fax
- --
- service@applichem.de
- Country
- Germany
- ProdList
- 968
- Advantage
- 65
- Tel
- --
- Fax
- --
- Country
- Germany
- ProdList
- 184
- Advantage
- 52
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
View Lastest Price from Cytidine 5'-monophosphate disodium salt manufacturers
- Product
- Cytidine 5'-Monophosphate Disodium Salt;CMP-Na2;5'-CMP-Na2 6757-06-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%min. HPLC
- Supply Ability
- 1000kg
- Release date
- 2024-09-11
- Product
- Cytidine 5'-monophosphate disodium salt 6757-06-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 500kg
- Release date
- 2022-05-24
- Product
- Cytidine 5’-monophosphate disodium salt 6757-06-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-05