SPDP
- Product Name
- SPDP
- CAS No.
- 68181-17-9
- Chemical Name
- SPDP
- Synonyms
- SPDP;SPDP NHS ester;SPDP Crosslinker;3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU;SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE;N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATE;3-(Pyridin-2-yldisulfanyl)-propionic acid-OS;3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU;N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE;N-[3-(2-Pyridyldithio)propionyloxy]succinimide
- CBNumber
- CB2446059
- Molecular Formula
- C12H12N2O4S2
- Formula Weight
- 312.36
- MOL File
- 68181-17-9.mol
SPDP Property
- Melting point:
- 84-86 °C(lit.)
- Boiling point:
- 465.9±55.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- acetone: 50 mg/mL
- form
- powder
- pka
- 1.76±0.19(Predicted)
- color
- White to Light Yellow
- BRN
- 1548137
- Stability:
- Hygroscopic, Moisture Sensitive
- InChIKey
- JWDFQMWEFLOOED-UHFFFAOYSA-N
- CAS DataBase Reference
- 68181-17-9(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- P3415
- Product name
- 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
- Purity
- ≥95%, powder
- Packaging
- 5mg
- Price
- $67.1
- Updated
- 2024/03/01
- Product number
- P3415
- Product name
- 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
- Purity
- ≥95%, powder
- Packaging
- 25mg
- Price
- $205
- Updated
- 2024/03/01
- Product number
- S0819
- Product name
- N-Succinimidyl 3-(2-Pyridyldithio)propionate
- Packaging
- 250MG
- Price
- $174
- Updated
- 2024/03/01
- Product number
- S0819
- Product name
- N-Succinimidyl 3-(2-Pyridyldithio)propionate
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $390
- Updated
- 2024/03/01
- Product number
- S0819
- Product name
- N-Succinimidyl 3-(2-Pyridyldithio)propionate
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
SPDP Chemical Properties,Usage,Production
Description
SPDP NHS ester is a heterobiofunctional crosslinker which can react with amine and sulfhydryl groups. SPDP NHS esters are membrane permeable therefore allowing them to funtion inside of cells.
Chemical Properties
White Solid
Uses
Important crosslinking reagent for the preparation of protein-protein and peptide-protein conjugates linked by disulfide bonds.
Uses
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker.
Uses
A heterobifunctional cross-linker
General Description
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.
SPDP Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SPDP manufacturers
- Product
- SPDP-NHS ester 68181-17-9
- Price
- US $0.00/g
- Min. Order
- 10g
- Purity
- >99.00%
- Supply Ability
- 10g
- Release date
- 2024-03-27
- Product
- SPDP 68181-17-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-10