(-)-BETA-HYDRASTINE

Product Name: (-)-BETA-HYDRASTINE
CAS No.: 118-08-1
Chemical Name: (-)-BETA-HYDRASTINE
Synonyms: HYDRASTINE;l-hydrastine;Hydrastine-RM;Hydrastinebase;(-)-Hydrastine;(+/-)-Nor-βquinolin-5-yl)-;(-)--Hydrastine;9S)-β-Hydrastine;(-)-B-HYDIASTINE
CBNumber: CB2456153
Molecular Formula: C21H21NO6
Formula Weight: 383.39
MOL File: 118-08-1.mol

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(-)-BETA-HYDRASTINE Property

Melting point:: 132℃
alpha: D20 -50° (c = 0.3 in abs alc)
Boiling point:: 510.32°C (rough estimate)
Density: 1.339±0.06 g/cm3 (20 ºC 760 Torr)
refractive index: 1.5614 (estimate)
storage temp.: −20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml
form: A crystalline solid
pka: 7.8(at 25℃)
color: White to light yellow
Water Solubility: 30mg/L(20 ºC)
CAS DataBase Reference: 118-08-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
RIDADR: 1544
WGK Germany: 3
RTECS: MU6030000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2939800000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1313210
Product name: (1R,9S)-(?)-β-Hydrastine
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 10mg
Price: $644
Updated: 2024/03/01

Cayman Chemical

Product number: 22363
Product name: (1R,9S)-(–)-β-Hydrastine
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 22363
Product name: (1R,9S)-(–)-β-Hydrastine
Purity: ≥98%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 22363
Product name: (1R,9S)-(–)-β-Hydrastine
Purity: ≥98%
Packaging: 25mg
Price: $235
Updated: 2024/03/01

Cayman Chemical

Product number: 22363
Product name: (1R,9S)-(–)-β-Hydrastine
Purity: ≥98%
Packaging: 50mg
Price: $401
Updated: 2024/03/01

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(-)-BETA-HYDRASTINE Chemical Properties,Usage,Production

Description

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC₅₀ = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC₅₀ value of 66.5 μM in the presence of high extracellular K⁺ levels. It also inhibits L-type and caffeine-activated store-operated Ca²⁺ channels and prevents Ca²⁺ leakage from intracellular stores.

Uses

anesthetic (local), antiarrhythmic

Uses

(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.

Definition

ChEBI: A natural product found in Hydrastis canadensis.

(-)-BETA-HYDRASTINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-BETA-HYDRASTINE Suppliers

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118-08-1, (-)-BETA-HYDRASTINERelated Search:

menisdaurin VERATRIDINE VERATRINE veratramine 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Xanthiside daurisoline Centella asiatica whole plant (-)-BETA-HYDRASTINE Narcotine NOSCAPINE HYDROCHLORIDE (+)-BETA-HYDRASTINE HCL HYDRASTININE HCL(RG) (+)-BETA-HYDRASTINE,D-BETA-HYDRASTINE,(1S,9R)-BETA-HYDRASTINE HYDRASTININE HYDROCHLORIDE NOSCAPINE HYDROCHLORIDE HYDRATE AKOS 244-30 TIMTEC-BB SBB006457

HYDRASTINE, (-)-B-(P) (AHP Verified)

HYDRASTINE, (-)-B-(P)

HYDRASTINE (D-beta-)

(-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE

9S)-β-Hydrastine

N-Desmethyl &beta

(+/-)-Nor-&beta

Hydrastine (base and/or unspecified salts)

(1R,9S)-(-)-β-Hydrastine

(3R)-6,7-Dimethoxy-3-[[(1R)-1,2,3,4-tetrahydro-2-methyl-6,7-(methylenedioxy)isoquinoline]-1-yl]isobenzofuran-1(3H)-one

[R,(-)]-6,7-Dimethoxy-3-[[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinoline]-5-yl]isobenzofuran-1(3H)-one

(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone

[S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one

6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one

6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one

(1R,9S)-B-hydrastine free base

Hydrastinebase

Hydrastine (10 mg)

l-beta-Hydrastine

l-hydrastine

Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-

phthalide,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)iso

quinolin-5-yl)-

HYDRASTINE

HYDRASTINE, (-)-B-

(-)-BETA-HYDRASTINE

(-)-B-HYDIASTINE

(1R,9S)-(-)-BETA-HYDRASTINE

(1R,9S)-BETA-HYDRASTINE

[S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone

1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-

6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one

1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)-

(1R,9S)-(–)-β-Hydrastine

(-)-β-Hydrastine

(-)--Hydrastine

(-)-BETA-HYDRASTINE

Hydrastine (1313210)

(-)-Hydrastine

(S)-6,7-dimethoxy-3-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one

Hydrastine,Inhibitor,inhibit

Hydrastine-RM

118-08-1

XYLOCAINE

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals