SNX 482

Product Name: SNX 482
CAS No.: 203460-30-4
Chemical Name: SNX 482
Synonyms: SNX-482 Recombinant;SNX-482 (0.1mg vial);C192H274N52O60S7 M.W. 4495.01;SNX 482, R-Type Ca2+ (Cav2.3) channel blocker
CBNumber: CB2497374
Molecular Formula: C192H274N52O60S7
Formula Weight: 4494.99736
MOL File: 203460-30-4.mol

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SNX 482 Property

storage temp.: −20°C
solubility: aqueous buffer: soluble
form: lyophilized powder
color: White to off-white
biological source: (from Hysterocrates gigas (African tarantula))
Water Solubility: Soluble in water
Sequence: Gly-Val-Asp-Lys-Ala-Gly-Cys-Arg-Tyr-Met-Phe-Gly-Gly-Cys-Ser-Val-Asn-Asp-Asp-Cys-Cys-Pro-Arg-Leu-Gly-Cys-His-Ser-Leu-Phe-Ser-Tyr-Cys-Ala-Trp-Asp-Leu-Thr-Phe-Ser-Asp (Disulfide bridge:Cys7-Cys21;Cys14-Cys26;Cys20-Cys33)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1150
Product name: SNX-482 Recombinant
Purity: ≥98% (HPLC)
Packaging: 5μG
Price: $155.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.08512
Product name: SNX-482 - CAS 203460-30-4 - Calbiochem
Packaging: 10μg
Price: $179
Updated: 2025/07/31

ApexBio Technology

Product number: B5351
Product name: SNX482
Packaging: 10ug
Price: $282
Updated: 2021/12/16

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SNX 482 Chemical Properties,Usage,Production

Uses

SNX-482, a peptide, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect[1][2][3].

Biological Activity

SNX-482 is a peptidyl toxin originally isolated from the venom of the spider Hysterocrates gigas. SNX-482 specifically blocks Cav2.3 (a1E, R-type) calcium channels in a voltage dependent manner. SNX-482 also blocks P/Q-type voltage-gated Ca2+ channels and blocks A-type K+ channels (IC50 of <3 nm).

in vivo

SNX-482 (0.5-4 μg/5 0μL; applied directly onto the spinal cord; 14-17 days post-operation) in the spinal nerve ligation (SNL) rat model dose - dependently inhibits nociceptive C-fiber and Aδ-fiber-mediated neuronal responses, and the responses to non-noxious mechanical and thermal stimuli are more sensitive in SNL rats than in sham - operated rats^[3].

Animal Model:	Male Sprague-Dawley rats (initially weighing 130-150 g) + Spinal nerve ligation^[3]
Dosage:	0.5 μg/50 μL, 1.5 μg/50 μL, 4 μg/50 μL
Administration:	Applied directly onto the spinal cord, 14-17 days post-operation
Result:	Exerted a significant dose-related inhibitory effect on C-fiber evoked responses, Aδ-fiber responses, post-discharge and input measurements. Inhibited the "wind-up" of neurons.

storage

-20°C (desiccate)

References

[1] R Newcomb, et al. Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry. 1998 Nov 3;37(44):15353-62. DOI:10.1021/bi981255g
[2] E Bourinet, et al. Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels. Biophys J. 2001 Jul;81(1):79-88. DOI:10.1016/S0006-3495(01)75681-0
[3] Elizabeth A Matthews, et al. The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur J Neurosci. 2007 Jun;25(12):3561-9. DOI:10.1111/j.1460-9568.2007.05605.x

SNX 482 Preparation Products And Raw materials

Raw materials

Preparation Products

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SNX 482 Suppliers

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C192H274N52O60S7 M.W. 4495.01

SNX 482, R-Type Ca2+ (Cav2.3) channel blocker

SNX-482 Recombinant

SNX-482 (0.1mg vial)

203460-30-4

C192H274N52O60S7

Calcium channel

Ion Channels