CYCLIC-PIFITHRIN-ALPHA
- Product Name
- CYCLIC-PIFITHRIN-ALPHA
- CAS No.
- 60477-34-1
- Chemical Name
- CYCLIC-PIFITHRIN-ALPHA
- Synonyms
- Pifithrin-2;Pifithrin-alpha (cyclic) . HBr;Pifithrin-β (QB-102 and Cyclic-Pifithrin-α);Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem;Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem;2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole;5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole;Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-
- CBNumber
- CB2504209
- Molecular Formula
- C16H16N2S
- Formula Weight
- 268.38
- MOL File
- 60477-34-1.mol
CYCLIC-PIFITHRIN-ALPHA Property
- Melting point:
- 266.4-267.3 °C(lit.)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 20 mg/mL
- form
- White solid
- pka
- 6.75±0.20(Predicted)
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- B4813
- Product name
- Pifithrin-β
- Packaging
- 5mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- B4813
- Product name
- Pifithrin-β
- Packaging
- 10mg
- Price
- $148
- Updated
- 2021/12/16
- Product number
- Axon3051
- Product name
- Pifithrin-β-PFT-β|Z-2-035II
- Purity
- 99%
- Packaging
- 2x10mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- API0017104
- Product name
- PIFITHRIN-B
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.16
- Updated
- 2021/12/16
- Product number
- B4813
- Product name
- Pifithrin-β
- Packaging
- 50mg
- Price
- $607
- Updated
- 2021/12/16
CYCLIC-PIFITHRIN-ALPHA Chemical Properties,Usage,Production
Uses
Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
Definition
ChEBI: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole is a member of imidazoles.
General Description
A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
Biochem/physiol Actions
Cell permeable: yes
References
[1] Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57. DOI:10.1016/j.bmc.2011.01.039
[2] Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83. DOI:10.1016/j.lfs.2011.02.019
[3] Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.
CYCLIC-PIFITHRIN-ALPHA Preparation Products And Raw materials
Raw materials
Preparation Products
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