2-ETHOXY-MALONIC ACID DIETHYL ESTER
Uses- Product Name
- 2-ETHOXY-MALONIC ACID DIETHYL ESTER
- CAS No.
- 37555-99-0
- Chemical Name
- 2-ETHOXY-MALONIC ACID DIETHYL ESTER
- Synonyms
- Diethyl ethoxymalonate;diethyl 2-ethoxymalonate;2-Hydroxydiethyl Malonate;Diethyl ethoxypropanedioate;Diethyl 2-ethoxy-malonic acid;diethyl 2-ethoxypropanedioate;1,3-diethyl 2-ethoxypropanedioate;ethoxy-malonic acid diethyl ester;2-ETHOXY-MALONIC ACID DIETHYL ESTER;Ethoxypropanedioic acid diethyl ester
- CBNumber
- CB2663320
- Molecular Formula
- C9H16O5
- Formula Weight
- 204.22
- MOL File
- 37555-99-0.mol
2-ETHOXY-MALONIC ACID DIETHYL ESTER Property
- Boiling point:
- 261℃
- Density
- 1.070
- Flash point:
- 108℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.29±0.46(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- W5840
- Product name
- Ethoxy-malonicaciddiethylester
- Packaging
- 5g
- Price
- $303
- Updated
- 2021/12/16
- Product number
- 073942
- Product name
- Ethoxymalonic acid diethyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
- Product number
- CHM0087307
- Product name
- 2-ETHOXY-MALONIC ACID DIETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1034.88
- Updated
- 2021/12/16
- Product number
- 073942
- Product name
- Ethoxymalonic acid diethyl ester
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1197
- Updated
- 2021/12/16
- Product number
- CHM0087307
- Product name
- 2-ETHOXY-MALONIC ACID DIETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2067.45
- Updated
- 2021/12/16
2-ETHOXY-MALONIC ACID DIETHYL ESTER Chemical Properties,Usage,Production
Uses
Diethyl ethoxymalonate is a hydroxyl malonic acid ester and a commonly used reagent in organic synthesis.
Synthesis
817-95-8
95-92-1
37555-99-0
Example 1: Scheme 4 Preparation of diethyl 2-ethoxy-malonate A mixture of diethyl oxalate (39.23 ml, 1.12 eq.) and ethyl 2-ethoxyacetate (34.95 ml, 1 eq.) was added dropwise to a slurry of sodium ethanolate (18.64 g, 1.07 eq.) in toluene (100 ml) at 45-50 °C. After the dropwise addition was completed, the reaction mixture was heated to 70-80°C and maintained for 2 hours. After completion of the reaction, the mixture was cooled and poured into 70 ml of 14% hydrochloric acid solution. The resulting mixture was extracted with ethyl acetate (EA), the organic layers were combined and washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 55.86 g (93.7% yield) of the target product diethyl 2-ethoxy-malonate.
References
[1] Patent: WO2011/80568, 2011, A2. Location in patent: Page/Page column 47-48
2-ETHOXY-MALONIC ACID DIETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
2-ETHOXY-MALONIC ACID DIETHYL ESTER Suppliers
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