5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE
- Product Name
- 5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE
- CAS No.
- 20869-95-8
- Chemical Name
- 5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE
- Synonyms
- ERMANIN;NSC 31882;Ermanin, 10 mM in DMSO;3,4'-Dimethoxykaempferol;KAEMPFEROL-3,4'-DIMETHYL ETHER;Kaempferol 3,4'-di-O-methyl ether;3,4'-DIMETHOXY-5,7-DIHYDROXYFLAVONE;5,7-DIHYDROXY-3,4'-DIMETHOXYFLAVONE;5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4-benzopyrone;5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE
- CBNumber
- CB2682172
- Molecular Formula
- C17H14O6
- Formula Weight
- 314.29
- MOL File
- 20869-95-8.mol
5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Property
- Melting point:
- 234 °C
- Boiling point:
- 552.0±50.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- solubility
- DMF: 20 mg/ml
DMSO: 15 mg/ml - pka
- 6.32±0.40(Predicted)
- LogP
- 2.400 (est)
N-Bromosuccinimide Price
- Product number
- FK66303
- Product name
- Kaempferol-3,4'-dimethyl ether
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FK66303
- Product name
- Kaempferol-3,4'-dimethyl ether
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- FK66303
- Product name
- Kaempferol-3,4'-dimethyl ether
- Packaging
- 250mg
- Price
- $218.75
- Updated
- 2021/12/16
- Product number
- W1683
- Product name
- Ermanin
- Packaging
- 250mg
- Price
- $347
- Updated
- 2021/12/16
- Product number
- FK66303
- Product name
- Kaempferol-3,4'-dimethyl ether
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Chemical Properties,Usage,Production
Uses
Ermanin is a useful research chemical used in HIV-1 integrase inhibition. Ermanin exhibits actioxidant properties against peroxyl and hydroxyl radicals.
Definition
ChEBI: 3,4'-dimethylkaempferol is a dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4' have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum. It has a role as an anti-inflammatory agent, an antimycobacterial drug, an apoptosis inducer, an antineoplastic agent and a plant metabolite. It is a dihydroxyflavone and a dimethoxyflavone. It is functionally related to a kaempferol.
IC 50
iNOS; Bacterial; COX-2
References
[1] QIONG DING . The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis[J]. Free Radical Biology and Medicine, 2021, 176: Pages 392-405. DOI: 10.1016/j.freeradbiomed.2021.09.017
[2] JOSÉ ANTONIO GUERRA. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids isolated from Tanacetum microphyllum[J]. International immunopharmacology, 2006, 6 11: Pages 1723-1728. DOI: 10.1016/j.intimp.2006.08.012
[3] NADINE DE MEYER. 4’-Hydroxy-3-methoxyflavones with potent antipicornavirus activity[J]. Journal of Medicinal Chemistry, 1991, 34 2: 736-746. DOI: 10.1021/jm00106a039
5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Preparation Products And Raw materials
Raw materials
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