ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-fluoropyrimidine

2,4-Dichloro-5-fluoropyrimidine

Product Name
2,4-Dichloro-5-fluoropyrimidine
CAS No.
2927-71-1
Chemical Name
2,4-Dichloro-5-fluoropyrimidine
Synonyms
5-FLUORO-2,4-DICHLOROPYRIMIDINE;oro-5-fL;NSC 70442;uoropyrimidine;CHEMPACIFIC 37950;Fluorouracil Impurity 9;2,6-DICHLORO-5-FLUORORACIL;2,4-Dichloro-5-fluorouracil;4-Dichloro-5-fluoropyriMidine;2,4-dichloro5-fluropyrimidine
CBNumber
CB2683700
Molecular Formula
C4HCl2FN2
Formula Weight
166.97
MOL File
2927-71-1.mol
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2,4-Dichloro-5-fluoropyrimidine Property

Melting point:
37-41 °C (lit.)
Boiling point:
80 °C / 16mmHg
Density 
1.605±0.06 g/cm3(Predicted)
Flash point:
223 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
soluble in Chloroform, Methanol
pka
-3.96±0.29(Predicted)
form 
Powder or Crystalline Powder or Low Melting Solid
color 
White to pale brown
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
InChIKey
WHPFEQUEHBULBW-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(F)C(Cl)=N1
CAS DataBase Reference
2927-71-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38-34-22
Safety Statements 
26-36-37/39-45-36/37/39
RIDADR 
3261
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
653233
Product name
2,4-Dichloro-5-fluoropyrimidine
Purity
97%
Packaging
1g
Price
$32.1
Updated
2024/03/01
TCI Chemical
Product number
D3374
Product name
2,4-Dichloro-5-fluoropyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
D3374
Product name
2,4-Dichloro-5-fluoropyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$78
Updated
2024/03/01
Alfa Aesar
Product number
H26288
Product name
5-Fluoro-2,4-dichloropyrimidine, 98%
Packaging
5g
Price
$58.6
Updated
2021/12/16
Alfa Aesar
Product number
H26288
Product name
5-Fluoro-2,4-dichloropyrimidine, 98%
Packaging
1g
Price
$21.1
Updated
2021/12/16
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2,4-Dichloro-5-fluoropyrimidine Chemical Properties,Usage,Production

Chemical Properties

2,4-Dichloro-5-fluoropyrimidine is Yellow to Orange Crystalline Solid

Uses

2,4-Dichloro-5-fluoropyrimidine is used in the synthesis of two glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors. It is used in the synthesis of two glucuronic derivatives of 5-fluorouracil as neoplasm inhibitors.

Uses

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:

  • 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
  • A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
  • 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
  • 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
  • 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
  • 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

Flammability and Explosibility

Not classified

2,4-Dichloro-5-fluoropyrimidine Preparation Products And Raw materials

Raw materials

N,N-Dimethylaniline 5-Fluorouracil

Preparation Products

5-Fluorocytosine
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View Lastest Price from 2,4-Dichloro-5-fluoropyrimidine manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
2,4-Dichloro-5-fluoropyrimidine 2927-71-1
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-21
Shaanxi Dideu Medichem Co. Ltd
Product
2,4-Dichloro-5-fluoropyrimidine 2927-71-1
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Henan Aochuang Chemical Co.,Ltd.
Product
2,4-Dichloro-5-fluoropyrimidine 2927-71-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-28

2927-71-1, 2,4-Dichloro-5-fluoropyrimidineRelated Search:

4-Bromo-2,6-difluorobenzoic acid 2,4-Dichloropyrimidine 5-Fluoropyrimidine Fluorocytosine 2-Chloro-5-fluoropyrimidine 2,4-Dichloro-5-methylpyrimidine Dichlorofluoroethane 4,6-Dichloro-5-fluoropyrimidine FMOC-D-3-Trifluoromethylphe 2-Fluoro-3,5-dichloropyridine 2,4-DICHLORO-6-ETHYL-5-FLUOROPYRIMIDINE 3,5-DICHLORO-4-FLUOROPYRIDINE 2-AMINO-4,6-DICHLORO-5-FLUOROPYRIMIDINE 2,4-DICHLORO-6-FLUOROPYRIMIDINE 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE Pyrimidine, 4-chloro-5-fluoro- (9CI) 2,4-Dichloro-5-fluoropyrimidine 2,4-dichloro-5-fluoro-6-methylpyrimidine

  • CHEMPACIFIC 37950
  • 5-FLUORO-2,4-DICHLOROPYRIMIDINE
  • 2,4-DICHLORO-5-FLUOROPYRIMIDINE
  • 2,4-Dichloro-5-fluorouracil
  • 5-Fluoro-2,4-dichloropyrimdine
  • 2,6-DICHLORO-5-FLUORORACIL
  • 2,4-Dichloro-5-Fluoropyrimidin
  • 2,4-Dichloro-5-fluoropyrimidine99%
  • 2,4-Dichloro-5-fluoropyrimidine ,98%
  • 2,4-Dicloro-5-fluoro pyrimidin
  • 2,4-Dichloro-5-fluoropyrimidine (Abemaciclib Mesylate)
  • oro-5-fL
  • uoropyrimidine
  • 4-Dichloro-5-fluoropyriMidine
  • 2,4-Dichloro-5-fluorpyriMidine
  • 2,4-Dichloro-5-fluoro-1,3-diazine
  • PyriMidine, 2,4-dichloro-5-fluoro-
  • 4-(2-vinyl-1,3-dioxolan-4-yl)butan-1-ol
  • 2,6-Dichloro-5-fluoropyriMidine
  • NSC 70442
  • 2,4-two chloro-5- fluorouracil
  • 5-Fluoro-2,4-dichloropyrimidine,98%
  • Pyrimidine, 5-fluoro-2,4-dichloro-
  • 5-fluoro-2,4-dichloropirimidine
  • 2,4-Dichloro-5-fluoropyrimidine&gt
  • 2,4-Dichloro-5-fluoropyrimidine ISO 9001：2015 REACH
  • 2,4-dichloro5-fluropyrimidine
  • TIANFU CHEM 2,4-Dichloro-5-fluoropyrimidine
  • 2,4-Dichloro-5-fluoropyrimidine?New
  • Fluorouracil Impurity 9
  • 2927-71-1
  • 2927-71-7
  • C4HCl2FN2
  • C4HCl2FN2O2
  • C4HCI2FN2
  • C4HN2Cl2F
  • Building Blocks
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyrimidines
  • Fluorine series
  • Aromatics
  • Bases & Related Reagents
  • Nucleotides
  • Pyrazines, Pyrimidines & Pyridazines
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyrimidines
  • PyrimidinesHeterocyclic Building Blocks
  • Building Blocks
  • Fluorinated
  • Nucleotides and Nucleosides
  • Pyridines, Pyrimidines, Purines and Pteredines
  • pharmacetical
  • Halides
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrimidine