ChemicalBook > CAS DataBase List > Ethyl 2-bromothiazole-5-carboxylate

Ethyl 2-bromothiazole-5-carboxylate

Product Name: Ethyl 2-bromothiazole-5-carboxylate
CAS No.: 41731-83-3
Chemical Name: Ethyl 2-bromothiazole-5-carboxylate
Synonyms: ETHYL 2-BROMO-1,3-THIAZOLE-5-CARBOXYLATE;RARECHEM AL BI 1435;Ethyl 2-bromothiazole-5-carboxylat;2-Bromo-5-(ethoxycarbonyl)thiazole;ETHYL 2-BROMOTHIAZOLE-5-CARBOXYLATE;Ethyl 2-bromo-5-thiazolecarboxylate;Ethyl 2-bromo-thiazol-5-carboxylate;Ethyl2-Bromothiazole-5-carboxylate>2-Bromo-5-(ethoxycarbonyl)-1,3-thiazole;ethyl 5-bromo-1,3-thiazole-2-carboxylate
CBNumber: CB2699886
Molecular Formula: C6H6BrNO2S
Formula Weight: 236.09
MOL File: 41731-83-3.mol

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Ethyl 2-bromothiazole-5-carboxylate Property

Melting point:: 60-61 °C(Solv: ligroine (8032-32-4))
Boiling point:: 216-217 °C (lit.)
Density: 1.581 g/mL at 25 °C (lit.)
refractive index: n20/D 1.5530(lit.)
Flash point:: >230 °F
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
pka: -0.98±0.10(Predicted)
form: clear liquid
color: Light orange to Yellow to Green
Water Solubility: Miscible is water.
InChI: InChI=1S/C6H6BrNO2S/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3
InChIKey: KTYIFXLNIMPSKI-UHFFFAOYSA-N
SMILES: S1C(C(OCC)=O)=CN=C1Br
CAS DataBase Reference: 41731-83-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
WGK Germany: 3
Hazard Note: Harmful/Keep Cold
HS Code: 29341000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 642495
Product name: Ethyl 2-bromothiazole-5-carboxylate
Purity: 97%
Packaging: 1g
Price: $32.6
Updated: 2023/06/20

Sigma-Aldrich

Product number: 642495
Product name: Ethyl 2-bromothiazole-5-carboxylate
Purity: 97%
Packaging: 5g
Price: $97.5
Updated: 2023/06/20

TCI Chemical

Product number: E0891
Product name: Ethyl 2-Bromothiazole-5-carboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $45
Updated: 2024/03/01

TCI Chemical

Product number: E0891
Product name: Ethyl 2-Bromothiazole-5-carboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $177
Updated: 2024/03/01

TRC

Product number: E900823
Product name: Ethyl 2-Bromothiazole-5-carboxylate
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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Ethyl 2-bromothiazole-5-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 2-bromothiazole-5-carboxylate is used in medicine, pharmaceutical intermediate

Synthesis

32955-21-8

41731-83-3

General procedure for the synthesis of ethyl 2-bromothiazole-5-carboxylate from ethyl 2-aminothiazole-5-carboxylate: to a stirred solution of ethyl 2-aminothiazole-5-carboxylate (10.0 g, 46.45 mmol, Combi block) in 48% hydrobromic acid (75 mL) at 0 °C, sodium nitrite (4.80 g, 50 mL) dissolved in water (50 mL) was added dropwise. 69.68 mmol) solution. The reaction mixture was continued to be stirred at 0 °C for 15 min. Subsequently, a 48% hydrobromic acid (75 mL) solution of copper(I) bromide (6.66 g, 46.45 mmol) was added dropwise at 0°C. The resulting reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane (200 mL), washed sequentially with water (50 mL) and brine (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the crude product by fast chromatography (100% chloroform) afforded ethyl 2-bromothiazole-5-carboxylate as a yellow liquid in 50% yield (5.5 g).LCMS (Method A): 235.9 (M + H), retention time 3.85 min, purity 98.6% (max).1H NMR (400 MHz, DMSO-d6): δ 8.16 (s, 1H ), 4.38 (q, J = 7.1 Hz, 2H), 1.39 (t, J = 7.1 Hz, 3H).

References

[1] Patent: WO2014/159234, 2014, A1. Location in patent: Page/Page column 87; 88
[2] Patent: WO2016/30443, 2016, A1. Location in patent: Page/Page column 118-119
[3] Patent: WO2017/144637, 2017, A1. Location in patent: Page/Page column 52; 53
[4] Patent: WO2017/144635, 2017, A1. Location in patent: Page/Page column 46; 47
[5] Journal of the American Chemical Society, 2008, vol. 130, # 28, p. 9089 - 9098

Ethyl 2-bromothiazole-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl 2-bromothiazole-5-carboxylate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Ethyl 2-bromothiazole-5-carboxylate 41731-83-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-05

Career Henan Chemical Co

Product: Ethyl 2-bromothiazole-5-carboxylate 41731-83-3
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-23

41731-83-3, Ethyl 2-bromothiazole-5-carboxylateRelated Search:

RESMETHRIN 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Fosthiazate 2-Bromo-5-thiazolecarboxylic acid Ethyl acetate Benzothiazole Ethyl acrylate Ethyl bromodifluoroacetate Ethanol 2-Mercaptobenzothiazole Ethyl pyruvate 2-Bromothiazole Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) ISOXADIFEN-ETHYL Ethyl bromoacetate Ethyl cyanoacetate Ethyl formate Ethylparaben

2-broMo-5-thiazolecarboxylic acid ethyl ester

Ethyl 2-bromo-5-thiazolecarboxylate

ethyl 5-bromo-1,3-thiazole-2-carboxylate

5-Thiazolecarboxylic acid, 2-broMo-, ethyl ester

2-Bromo-5-(ethoxycarbonyl)-1,3-thiazole

ETHYL 2-BROMO-1,3-THIAZOLE-5-CARBOXYLATE

ETHYL 2-BROMOTHIAZOLE-5-CARBOXYLATE

RARECHEM AL BI 1435

2-BROMO-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Ethyl 2-bromothiazole-5-carboxylat

JR-8416, Ethyl 2-bromothiazole-5-carboxylate, 97%

Ethyl2-Bromothiazole-5-carboxylate&gt

2-Bromo-5-(ethoxycarbonyl)thiazole

5-Thiazolecarboxylic acid, 2-bromo-, ethyl ester (6CI, 9CI, ACI)

2-bromo-5-Thiazolecarboxylic acid ethyl ester (6CI 9CI ACI)

Ethyl 2-bromo-thiazol-5-carboxylate

41731-83-3

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Thiazoles

Building Blocks

C3 to C7

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Thiazole

Thiazoles, Isothiazoles & Benzothiazoles

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

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blocks

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Thiazoles, Isothiazoles &Benzothiazoles