Ethyl 2-bromothiazole-5-carboxylate
- Product Name
- Ethyl 2-bromothiazole-5-carboxylate
- CAS No.
- 41731-83-3
- Chemical Name
- Ethyl 2-bromothiazole-5-carboxylate
- Synonyms
- ETHYL 2-BROMO-1,3-THIAZOLE-5-CARBOXYLATE;RARECHEM AL BI 1435;Ethyl 2-bromothiazole-5-carboxylat;2-Bromo-5-(ethoxycarbonyl)thiazole;ETHYL 2-BROMOTHIAZOLE-5-CARBOXYLATE;Ethyl 2-bromo-5-thiazolecarboxylate;Ethyl 2-bromo-thiazol-5-carboxylate;Ethyl2-Bromothiazole-5-carboxylate>2-Bromo-5-(ethoxycarbonyl)-1,3-thiazole;ethyl 5-bromo-1,3-thiazole-2-carboxylate
- CBNumber
- CB2699886
- Molecular Formula
- C6H6BrNO2S
- Formula Weight
- 236.09
- MOL File
- 41731-83-3.mol
Ethyl 2-bromothiazole-5-carboxylate Property
- Melting point:
- 60-61 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 216-217 °C (lit.)
- Density
- 1.581 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.5530(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- -0.98±0.10(Predicted)
- form
- clear liquid
- color
- Light orange to Yellow to Green
- Water Solubility
- Miscible is water.
- InChI
- InChI=1S/C6H6BrNO2S/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3
- InChIKey
- KTYIFXLNIMPSKI-UHFFFAOYSA-N
- SMILES
- S1C(C(OCC)=O)=CN=C1Br
- CAS DataBase Reference
- 41731-83-3(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- 642495
- Product name
- Ethyl 2-bromothiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $32.6
- Updated
- 2023/06/20
- Product number
- 642495
- Product name
- Ethyl 2-bromothiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $97.5
- Updated
- 2023/06/20
- Product number
- E0891
- Product name
- Ethyl 2-Bromothiazole-5-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $45
- Updated
- 2024/03/01
- Product number
- E0891
- Product name
- Ethyl 2-Bromothiazole-5-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $177
- Updated
- 2024/03/01
- Product number
- E900823
- Product name
- Ethyl 2-Bromothiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
Ethyl 2-bromothiazole-5-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 2-bromothiazole-5-carboxylate is used in medicine, pharmaceutical intermediate
Synthesis
32955-21-8
41731-83-3
General procedure for the synthesis of ethyl 2-bromothiazole-5-carboxylate from ethyl 2-aminothiazole-5-carboxylate: to a stirred solution of ethyl 2-aminothiazole-5-carboxylate (10.0 g, 46.45 mmol, Combi block) in 48% hydrobromic acid (75 mL) at 0 °C, sodium nitrite (4.80 g, 50 mL) dissolved in water (50 mL) was added dropwise. 69.68 mmol) solution. The reaction mixture was continued to be stirred at 0 °C for 15 min. Subsequently, a 48% hydrobromic acid (75 mL) solution of copper(I) bromide (6.66 g, 46.45 mmol) was added dropwise at 0°C. The resulting reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane (200 mL), washed sequentially with water (50 mL) and brine (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification of the crude product by fast chromatography (100% chloroform) afforded ethyl 2-bromothiazole-5-carboxylate as a yellow liquid in 50% yield (5.5 g).LCMS (Method A): 235.9 (M + H), retention time 3.85 min, purity 98.6% (max).1H NMR (400 MHz, DMSO-d6): δ 8.16 (s, 1H ), 4.38 (q, J = 7.1 Hz, 2H), 1.39 (t, J = 7.1 Hz, 3H).
References
[1] Patent: WO2014/159234, 2014, A1. Location in patent: Page/Page column 87; 88
[2] Patent: WO2016/30443, 2016, A1. Location in patent: Page/Page column 118-119
[3] Patent: WO2017/144637, 2017, A1. Location in patent: Page/Page column 52; 53
[4] Patent: WO2017/144635, 2017, A1. Location in patent: Page/Page column 46; 47
[5] Journal of the American Chemical Society, 2008, vol. 130, # 28, p. 9089 - 9098
Ethyl 2-bromothiazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-bromothiazole-5-carboxylate manufacturers
- Product
- Ethyl 2-bromothiazole-5-carboxylate 41731-83-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-05
- Product
- Ethyl 2-bromothiazole-5-carboxylate 41731-83-3
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-23