Phenyl chloroformate

Product Name: Phenyl chloroformate
CAS No.: 1885-14-9
Chemical Name: Phenyl chloroformate
Synonyms: Phenyl carbonochloridate;CARBONOCHLORIDIC ACID;chlorocarbonic acid;PHENYL CHLOROCARBONATE;CHLOROFORMIC ACID PHENYL ESTER;carbonochloridic acid phenyl ester;tl398;PHENYL CHLOROFORMAT;Phenyl choroformate;PHENYL CHLOROFORMATE
CBNumber: CB2702258
Molecular Formula: C7H5ClO2
Formula Weight: 156.57
MOL File: 1885-14-9.mol

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Phenyl chloroformate Property

Melting point:: -28 °C
Boiling point:: 74-75 °C/13 mmHg (lit.)
Density: 1.248 g/mL at 25 °C (lit.)
vapor density: 1 (vs air)
vapor pressure: 1.22 psi ( 20 °C)
refractive index: n20/D 1.511(lit.)
Flash point:: 168 °F
storage temp.: 2-8°C
solubility: Miscible with N,N-dimethylformamide.
form: Liquid
color: Clear
Water Solubility: hydrolysis
Sensitive: Moisture Sensitive
BRN: 606778
CAS DataBase Reference: 1885-14-9(CAS DataBase Reference)
NIST Chemistry Reference: Carbonochloridic acid, phenyl ester(1885-14-9)
EPA Substance Registry System: Carbonochloridic acid, phenyl ester (1885-14-9)

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Safety

Hazard Codes: T+
Risk Statements: 22-26-34-41-38-29-37
Safety Statements: 26-28-36/37/39-45-28A
RIDADR: UN 2746 6.1/PG 2
WGK Germany: 3
RTECS: FG3850000
F: 10-19-21
Autoignition Temperature: 540 °C
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29159020
Toxicity: LD50 orally in Rabbit: 1730 mg/kg LD50 dermal Rabbit 4880 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H330Fatal if inhaled

H335May cause respiratory irritation

Precautionary statements

P234Keep only in original container.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.02353
Product name: Phenyl chloroformate
Purity: for synthesis
Packaging: 250ML
Price: $80.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 237906
Product name: Phenyl chloroformate
Purity: 97%
Packaging: 5g
Price: $89.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: 167525
Product name: Phenyl chloroformate
Purity: 99%
Packaging: 100g
Price: $82.3
Updated: 2024/03/01

TCI Chemical

Product number: C0649
Product name: Phenyl Chloroformate
Purity: >98.0%(GC)(T)
Packaging: 25mL
Price: $20
Updated: 2024/03/01

TCI Chemical

Product number: C0649
Product name: Phenyl Chloroformate
Purity: >98.0%(GC)(T)
Packaging: 100mL
Price: $34
Updated: 2024/03/01

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Phenyl chloroformate Chemical Properties,Usage,Production

Chemical Properties

clear oily liquid. Corrosive. Insoluble in water, soluble in ethanol, ether, easily soluble in petroleum ether.

Uses

Phenyl chloroformate is used in the synthesis of poly(2-(phenoxycarbonyloxy)ethyl methacrylate) and phenyl-(4-vinylphenyl) carbonate. It acts as a precursor of phenyl mixed anhydrides which are used in peptide coupling reactions. It serves as a dehydrating reagent for the conversion of primary amides to nitriles and an intermediate in the synthesis of pharmaceuticals and carbamates.

Preparation

Phenyl chloroformate is synthesized by the reaction of phenol with phosgene. Phenol was dissolved in chloroform, phosgene was introduced under cooling, and the absorbed phosgene was in an equal molar ratio to phenol, and equimolar N,N-dimethylaniline was added dropwise under stirring at 5-10 °C. Then add cold water to dilute, separate the oil layer, wash with dilute hydrochloric acid and water successively. After drying with anhydrous calcium chloride, chloroform is evaporated, and then distilled under reduced pressure to collect 74-75°C (1.73kPa) fraction, which is phenyl chloroformate. The yield is about 90%.

Application

Phenyl chloroformate is an important organic synthesis intermediate, which is widely used in chemical synthesis and can be used as polymer catalyst, plastic modifier, fiber treatment agent, and intermediate of medicine and pesticide.

General Description

Phenyl chloroformate appears as a colorless liquid with a strong odor. Toxic by ingestion, inhalation and skin absorption. Very irritating to skin and eyes. Used as a reagent for organic synthesis.

Air & Water Reactions

Emits fumes containing HCl in moist air. Decomposes in water to form HCl.

Reactivity Profile

Phenyl chloroformate is incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Safety Profile

Poison by inhalation. Moderately toxic by ingestion and skin contact. A corrosive sktn and eye irritant. See also ESTERS. When heated to decomposition it emits toxic fumes of Cl-.

Phenyl chloroformate Preparation Products And Raw materials

Raw materials

Triphosgene Calcium chloride Phenol N,N-Dimethylaniline Dichloromethane

Preparation Products

Xamoterol hemifumarate Rilmenidine camazepam 5-BROMO-2(3H)-BENZOXAZOLONE 1,4-Benzenedimethanol Leuprorelin

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Phenyl chloroformate Suppliers

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View Lastest Price from Phenyl chloroformate manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Phenyl chloroformate 1885-14-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-14

Qingdao RENAS Polymer Material Co., Ltd.

Product: Carbonochloridic acid, phenyl ester 1885-14-9
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-08-20

Hebei Chuanghai Biotechnology Co,.LTD

Product: Phenyl chloroformate 1885-14-9
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-23

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Phenyl chloroformate 1885-14-9

1885-14-9

ClCOOC6H5

OCClOH

C6H5OCOCl

ClCO2C6H5

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