ROLIPRAM

Product Name: ROLIPRAM
CAS No.: 61413-54-5
Chemical Name: ROLIPRAM
Synonyms: 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE;SB 95952;ROLIPRAM;ZK-62711;Roliprame;(¨¤)-Rolipr;Rolipram >ROLIPRAM 98+%;(R,S)-Rolipram;Rolipram, >=97%
CBNumber: CB2703866
Molecular Formula: C16H21NO3
Formula Weight: 275.34
MOL File: 61413-54-5.mol

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ROLIPRAM Property

Melting point:: 127-133 °C
Boiling point:: 418.29°C (rough estimate)
Density: 1.0677 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: H₂O: 0.2 mg/mL
form: solid
pka: 16.02±0.40(Predicted)
color: white to off-white
Merck: 14,8251
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-11
Safety Statements: 26-36
RIDADR: 3249
WGK Germany: 3
RTECS: UY5749237
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29337900
Toxicity: LD50 oral in mouse: > 300mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R6520
Product name: Rolipram
Purity: solid, ≥98% (HPLC)
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Sigma-Aldrich

Product number: 557330
Product name: Rolipram
Packaging: 5mg
Price: $230
Updated: 2024/03/01

TCI Chemical

Product number: R0110
Product name: Rolipram
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $198
Updated: 2024/03/01

TCI Chemical

Product number: R0110
Product name: Rolipram
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $686
Updated: 2024/03/01

Alfa Aesar

Product number: J67177
Product name: Rolipram, 98%
Packaging: 5mg
Price: $61.1
Updated: 2023/06/20

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ROLIPRAM Chemical Properties,Usage,Production

Description

Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and synergizes with forskolin (cat.# 10-2073). Cell permeable.

Chemical Properties

Yellowish solid

Uses

antipsychotic

Uses

A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4).

Uses

Pharmacological tool for characterization of phosphodiesterase isoenzymes.

Uses

(±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.

Definition

ChEBI: Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

General Description

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.

Biological Activity

Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC 50 = 2.0 μ M). Discriminates between two conformational states of PDE4 isoenzymes. See separate isomers ((R)-(-)-Rolipram and (S)-(+)-Rolipram).

Biochem/physiol Actions

Cell permeable: yes

storage

Room temperature

References

1) Reeves et al. (1987), The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase; Biochem. J., 241 535 2) Nishi et al. (2008), Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum; J. Neurosci., 28 10460 3) Christiansen et al. (2011), Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP; Neurochem. Int., 59 837

ROLIPRAM Preparation Products And Raw materials

Raw materials

Preparation Products

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ROLIPRAM Suppliers

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View Lastest Price from ROLIPRAM manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: rolipram 61413-54-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: ROLIPRAM 61413-54-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kgs
Release date: 2020-02-14

61413-54-5, ROLIPRAMRelated Search:

Rolapitant Donepezil PP242 Milrinone WORTMANNIN Vinpocetine Cilostazol Forskolin 2-Pyrrolidinone S- (+)-Rolipram ROLIPRAM (R)-(-)-ROLIPRAM,(S)-(+)-ROLIPRAM,Rolipram (R)-(-)- [METHYL-3H]ROLIPRAM ROLIPRAM [6-3H] S-Desmethyl-Rolipram (+)-Desmethyl-Rolipram,R-Desmethyl-Rolipram (R,S)-Desmethyl-Rolipram (R)-(-)-ROLIPRAM, >98%

ROLIPRAM 98+%

Roliprame

2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-

SB 95952

4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK62711

4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE

4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE

(R,S)-Rolipram

ZK-62711, SB95952, ME-3167

Rolipram, >=97%

SB95952;ZK62711;(R;S)-ROLIPRAM;SB 95952;ZK 62711;SB-95952;ZK-62711

Rolipram - CAS 61413-54-5 - Calbiochem

ROLIPRAM

PYRROLIDIN-2-ONE, 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)- (+/-)

ZK-62711

4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon

Rolipram, 98%, a PDE4 inhibitor

Rolipram &gt

Rolipram Rolipram

ROLIPRAM USP/EP/BP

Rolipram - CAS 61413-54-5

Rolipram (ME 3167

RolipramQ: What is Rolipram Q: What is the CAS Number of Rolipram Q: What is the storage condition of Rolipram Q: What are the applications of Rolipram

Rolipram (ZK-62711)

(¨¤)-Rolipr

(R,S)-Rolipram, Selective PDE4 inhibitor

61413-54-5

C16H21NO3

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Cyclic Nucleotide Metabolism

G Proteins and Cyclic Nucleotides

Phosphodiesterase Inhibitors

Inhibitor

DIPIPERON

Inhibitors

Antineoplastic

Cyclic Nucleotide related

Signalling