Uses
ChemicalBook > CAS DataBase List > 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE

3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE

Uses
Product Name
3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE
CAS No.
41965-95-1
Chemical Name
3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE
Synonyms
TECO-001;BIO-FARMA BF004393;Avanafil Impurity 68;Avanafil Impurity 22 HCl;3-chloro-4-methoxybenzylamineHCl;3-Chloro-4-MehoxyBenzylamine HCL;4-AMINOMETHYL-2-CHLOROANISOLE HCL;3-chloro-4-methoxybenzylamine, HC;3-Chloro-4-methoxybenzylamineHCl95%;1-Chloro-4-methoxybenzenemethanamine
CBNumber
CB2723099
Molecular Formula
C8H11Cl2NO
Formula Weight
208.09
MOL File
41965-95-1.mol
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3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Property

Melting point:
250-255 °C (lit.)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
Solid
color 
White to Almost white
InChI
InChI=1S/C8H10ClNO.ClH/c1-11-8-3-2-6(5-10)4-7(8)9;/h2-4H,5,10H2,1H3;1H
InChIKey
IKWWOZCEHOYKAO-UHFFFAOYSA-N
SMILES
NCC1=CC=C(OC)C(Cl)=C1.[H]Cl
CAS DataBase Reference
41965-95-1(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25-37/38-41
Safety Statements 
26-36/37-45-39
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
IRRITANT
HazardClass 
6.1
HS Code 
2922290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
657441
Product name
3-Chloro-4-methoxybenzylamine hydrochloride
Purity
97%
Packaging
5g
Price
$134
Updated
2023/06/20
TCI Chemical
Product number
C2903
Product name
3-Chloro-4-methoxybenzylamine Hydrochloride
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
C2903
Product name
3-Chloro-4-methoxybenzylamine Hydrochloride
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$44
Updated
2025/07/31
TRC
Product number
C349635
Product name
3-Chloro-4-methoxybenzylamine Hydrochloride
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
C349635
Product name
3-Chloro-4-methoxybenzylamine Hydrochloride
Packaging
1g
Price
$75
Updated
2021/12/16
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3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

3-Chloro-4-methoxybenzylamine hydrochloride can be used to synthesize avanafil; it is an intermediate side chain in the synthesis of avanafil.

Chemical Properties

White powder solid

Synthesis

2393-23-9

41965-95-1

General procedure for the synthesis of 3-chloro-4-methoxybenzylamine hydrochloride from 4-methoxybenzylamine: acetic acid (100 ml) was slowly added to 4-methoxybenzylamine (100 g) at 25-30 °C. Subsequently, additional acetic acid (750 ml) was added to the reaction mixture. Sulfonyl chloride (87.84 ml) was slowly added dropwise to the reaction mixture at 20-25 °C and stirred continuously for 6 h at the same temperature. After completion of the reaction, methyl tert-butyl ether (850 ml) was added to the reaction mixture at 25-30 °C. The reaction mixture was cooled to 15-20°C and stirring was continued at this temperature for 1 hour. The precipitated solid product was filtered, washed with methyl tert-butyl ether and dried to give 3-chloro-4-methoxybenzylamine hydrochloride. Yield: 118 g.

References

[1] Synthesis, 2003, # 3, p. 403 - 407
[2] Synthetic Communications, 2000, vol. 30, # 14, p. 2609 - 2612
[3] Tetrahedron, 2003, vol. 59, # 35, p. 6991 - 7009
[4] Organic letters, 2001, vol. 3, # 25, p. 4063 - 4066
[5] Patent: WO2015/1567, 2015, A1. Location in patent: Page/Page column 21

3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Suppliers

Americas 1 China 251 Europe 1 France 3 Germany 5 India 4 Japan 2 Switzerland 1 United Kingdom 12 United States 18 Global 298
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE manufacturers

Handan City Zechi trading Co., LTD
Product
3-Chloro-4-methoxybenzylaminehydrochloride 41965-95-1
Price
US $1.00/g
Min. Order
100g
Purity
99
Supply Ability
1000
Release date
2025-08-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-Chloro-4-methoxybenzylamine hydrochloride 41965-95-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-03
Henan Aochuang Chemical Co.,Ltd.
Product
3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE 41965-95-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19

41965-95-1, 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDERelated Search:

3-CHLORO-2,6-DIFLUOROBENZOIC ACID 3-Chloro-4-fluoro Methyl benzoate 3-CHLORO-4-FLUOROBENZENESULFONYL CHLORIDE 3-Chloro-2,4-difluorobenzoic acid 3-Chloro-1-(N,N-dimethyl)propylamine N-Methylbenzylamine 4-Methylbenzylamine Benzyl alcohol p-Anisidine 7-Amino-heptanoic acid ethyl ester hydrochloride Estradiene dione-3-keta 3-Chloro-6-methyl-dibenzo[c,f][1,2]thiazepin-11(6H)-one 5,5-dioxide 3-Methyl-3-oxetanemethanol 3-Acetyl-5-chlorothiophene-2-sulfonamide 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide 4-Methoxybenzylamine 2-Chloroanisole 5-CHLORO-2-METHOXYBENZYLAMINE HYDROCHLORIDE

  • BIO-FARMA BF004393
  • 3-chloro-4-methoxybenzylamine, HC
  • 4-AMINOMETHYL-2-CHLOROANISOLE HCL
  • 4-AMINOMETHYL-2-CHLOROANISOLE HYDROCHLORIDE
  • 3-chloro-4-methoxybenzylamineHCl
  • 3-Chloro-4-methoxybenzylamineHCl95%
  • 3-Chloro-4-methoxybenzylaminehydrochloride95%
  • 3-Chloro-4-methoxybenzylamine hydrochloride 95%
  • 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE
  • (3-chloro-4-methoxyphenyl)methylammonium chloride
  • 1-(3-chloro-4-methoxyphenyl)methanamine Hydrochloride
  • (3-chloro-4-methoxyphenyl)methanamine hydrochloride in stock Factory
  • 1-Chloro-4-methoxybenzenemethanamine
  • 3-chloro-4-MethoxybenzylaMniehydrochloride
  • (3-chloro-4-Methoxyphenyl)MethanaMine hydrochloride
  • 3-Chloro-4-MethoxybenzeneMethanaMine hydrochloride
  • BenzeneMethanaMine, 3-chloro-4-Methoxy-, hydrochloride (1:1)
  • BenzeneMethanaMine, 3-chloro-4-Methoxy-, hydrochloride
  • (3-chloro-4-Methoxyphenyl)MethanaMiniuM hydrochloride
  • 3-Chloro-4-MehoxyBenzylamine HCL
  • 3-chloro-4-methoxybenzylamine hydrochloride(AvanafilIntermediates)
  • 3-Chloro-4-methoxybenzylamineHydrochloride&gt
  • Avanafil Impurity 68
  • (3-chloro-4-methoxyphenyl) methylamine hydrochloride
  • 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE ISO 9001：2015 REACH
  • Avanafil intermediates，(3-chloro-4- methoxyphenyl)methanaminium hydrochloride
  • 3-chloro-4-methoxybenzylamine hydrochloric acid
  • 3-chloro-4-methoxyphenyl)methanaminium hydrochlor
  • TECO-001
  • 3-chloro-4-methoxy-Benzenemethanamine hydrochloride (1:1)
  • (3-chloro-4-methoxyphenyl)methanaminium chloride
  • 3-Chloro-4-methoxyphenyl metanamine, 98%min
  • Avanafil Impurity 22 HCl
  • 3-Chloro-4-methoxy-benzenemethanamine HCl
  • 41965-95-1
  • C9H11ClNO
  • Anilines, Aromatic Amines and Nitro Compounds
  • pharmacetical
  • Anilines, Amides & Amines
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Chlorine Compounds
  • Benzene derivatives
  • Amine Salts
  • Nitrogen Compounds
  • Organic Building Blocks
  • 41965-95-1