ChemicalBook > CAS DataBase List > 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE

3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE

Uses

Product Name: 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE
CAS No.: 41965-95-1
Chemical Name: 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE
Synonyms: TECO-001;BIO-FARMA BF004393;Avanafil Impurity 68;Avanafil Impurity 22 HCl;3-chloro-4-methoxybenzylamineHCl;3-Chloro-4-MehoxyBenzylamine HCL;4-AMINOMETHYL-2-CHLOROANISOLE HCL;3-chloro-4-methoxybenzylamine, HC;3-Chloro-4-methoxybenzylamineHCl95%;1-Chloro-4-methoxybenzenemethanamine
CBNumber: CB2723099
Molecular Formula: C8H11Cl2NO
Formula Weight: 208.09
MOL File: 41965-95-1.mol

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3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Property

Melting point:: 250-255 °C (lit.)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: Solid
color: White to Almost white
InChI: InChI=1S/C8H10ClNO.ClH/c1-11-8-3-2-6(5-10)4-7(8)9;/h2-4H,5,10H2,1H3;1H
InChIKey: IKWWOZCEHOYKAO-UHFFFAOYSA-N
SMILES: NCC1=CC=C(OC)C(Cl)=C1.[H]Cl
CAS DataBase Reference: 41965-95-1(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25-37/38-41
Safety Statements: 26-36/37-45-39
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Toxic
HazardClass: IRRITANT
HazardClass: 6.1
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 657441
Product name: 3-Chloro-4-methoxybenzylamine hydrochloride
Purity: 97%
Packaging: 5g
Price: $134
Updated: 2023/06/20

TCI Chemical

Product number: C2903
Product name: 3-Chloro-4-methoxybenzylamine Hydrochloride
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: C2903
Product name: 3-Chloro-4-methoxybenzylamine Hydrochloride
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $44
Updated: 2025/07/31

TRC

Product number: C349635
Product name: 3-Chloro-4-methoxybenzylamine Hydrochloride
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: C349635
Product name: 3-Chloro-4-methoxybenzylamine Hydrochloride
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

3-Chloro-4-methoxybenzylamine hydrochloride can be used to synthesize avanafil; it is an intermediate side chain in the synthesis of avanafil.

Chemical Properties

White powder solid

Synthesis

2393-23-9

41965-95-1

General procedure for the synthesis of 3-chloro-4-methoxybenzylamine hydrochloride from 4-methoxybenzylamine: acetic acid (100 ml) was slowly added to 4-methoxybenzylamine (100 g) at 25-30 °C. Subsequently, additional acetic acid (750 ml) was added to the reaction mixture. Sulfonyl chloride (87.84 ml) was slowly added dropwise to the reaction mixture at 20-25 °C and stirred continuously for 6 h at the same temperature. After completion of the reaction, methyl tert-butyl ether (850 ml) was added to the reaction mixture at 25-30 °C. The reaction mixture was cooled to 15-20°C and stirring was continued at this temperature for 1 hour. The precipitated solid product was filtered, washed with methyl tert-butyl ether and dried to give 3-chloro-4-methoxybenzylamine hydrochloride. Yield: 118 g.

References

[1] Synthesis, 2003, # 3, p. 403 - 407
[2] Synthetic Communications, 2000, vol. 30, # 14, p. 2609 - 2612
[3] Tetrahedron, 2003, vol. 59, # 35, p. 6991 - 7009
[4] Organic letters, 2001, vol. 3, # 25, p. 4063 - 4066
[5] Patent: WO2015/1567, 2015, A1. Location in patent: Page/Page column 21

3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE Suppliers

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View Lastest Price from 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE manufacturers

Handan City Zechi trading Co., LTD

Product: 3-Chloro-4-methoxybenzylaminehydrochloride 41965-95-1
Price: US $1.00/g
Min. Order: 100g
Purity: 99
Supply Ability: 1000
Release date: 2025-08-11

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-Chloro-4-methoxybenzylamine hydrochloride 41965-95-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-03

Henan Aochuang Chemical Co.,Ltd.

Product: 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE 41965-95-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

41965-95-1, 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDERelated Search:

3-CHLORO-2,6-DIFLUOROBENZOIC ACID 3-Chloro-4-fluoro Methyl benzoate 3-CHLORO-4-FLUOROBENZENESULFONYL CHLORIDE 3-Chloro-2,4-difluorobenzoic acid 3-Chloro-1-(N,N-dimethyl)propylamine N-Methylbenzylamine 4-Methylbenzylamine Benzyl alcohol p-Anisidine 7-Amino-heptanoic acid ethyl ester hydrochloride Estradiene dione-3-keta 3-Chloro-6-methyl-dibenzo[c,f][1,2]thiazepin-11(6H)-one 5,5-dioxide 3-Methyl-3-oxetanemethanol 3-Acetyl-5-chlorothiophene-2-sulfonamide 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide 4-Methoxybenzylamine 2-Chloroanisole 5-CHLORO-2-METHOXYBENZYLAMINE HYDROCHLORIDE

BIO-FARMA BF004393

3-chloro-4-methoxybenzylamine, HC

4-AMINOMETHYL-2-CHLOROANISOLE HCL

4-AMINOMETHYL-2-CHLOROANISOLE HYDROCHLORIDE

3-chloro-4-methoxybenzylamineHCl

3-Chloro-4-methoxybenzylamineHCl95%

3-Chloro-4-methoxybenzylaminehydrochloride95%

3-Chloro-4-methoxybenzylamine hydrochloride 95%

3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE

(3-chloro-4-methoxyphenyl)methylammonium chloride

1-(3-chloro-4-methoxyphenyl)methanamine Hydrochloride

(3-chloro-4-methoxyphenyl)methanamine hydrochloride in stock Factory

1-Chloro-4-methoxybenzenemethanamine

3-chloro-4-MethoxybenzylaMniehydrochloride

(3-chloro-4-Methoxyphenyl)MethanaMine hydrochloride

3-Chloro-4-MethoxybenzeneMethanaMine hydrochloride

BenzeneMethanaMine, 3-chloro-4-Methoxy-, hydrochloride (1:1)

BenzeneMethanaMine, 3-chloro-4-Methoxy-, hydrochloride

(3-chloro-4-Methoxyphenyl)MethanaMiniuM hydrochloride

3-Chloro-4-MehoxyBenzylamine HCL

3-chloro-4-methoxybenzylamine hydrochloride(AvanafilIntermediates)

3-Chloro-4-methoxybenzylamineHydrochloride&gt

Avanafil Impurity 68

(3-chloro-4-methoxyphenyl) methylamine hydrochloride

3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE ISO 9001：2015 REACH

Avanafil intermediates，(3-chloro-4- methoxyphenyl)methanaminium hydrochloride

3-chloro-4-methoxybenzylamine hydrochloric acid

3-chloro-4-methoxyphenyl)methanaminium hydrochlor

TECO-001

3-chloro-4-methoxy-Benzenemethanamine hydrochloride (1:1)

(3-chloro-4-methoxyphenyl)methanaminium chloride

3-Chloro-4-methoxyphenyl metanamine, 98%min

Avanafil Impurity 22 HCl

3-Chloro-4-methoxy-benzenemethanamine HCl

41965-95-1

C9H11ClNO

Anilines, Aromatic Amines and Nitro Compounds

pharmacetical

Anilines, Amides & Amines

Anisoles, Alkyloxy Compounds & Phenylacetates

Chlorine Compounds

Benzene derivatives

Amine Salts

Nitrogen Compounds

Organic Building Blocks

41965-95-1