Nortropinone hydrochloride

Product Name: Nortropinone hydrochloride
CAS No.: 25602-68-0
Chemical Name: Nortropinone hydrochloride
Synonyms: NORTROPINONE HCL;8-Azabicyclo[3.2.1]octan-3-one hydrochloride;Ntp·HCl;Tropicanol;ABLOCK AB-10-5429;Nortropinone HCl ,98%;Nortropinone HydrochL;NORTROPINONE HYDROCHLORIDE;Nortropanone Hydrochloride;Nortropinone hydroehloride
CBNumber: CB2724566
Molecular Formula: C7H12ClNO
Formula Weight: 161.63
MOL File: 25602-68-0.mol

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Nortropinone hydrochloride Property

Melting point:: >180°C (dec.)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform, Dichloromethane, Methanol
form: Solid
color: White to yellow-brown
Sensitive: Hygroscopic
InChI: InChI=1/C7H11NO.ClH/c9-7-3-5-1-2-6(4-7)8-5;/h5-6,8H,1-4H2;1H/t5-,6+;
InChIKey: MZQWQFWRSDNBPV-KNCHESJLNA-N
SMILES: [C@]12([H])CC[C@]([H])(CC(=O)C1)N2.Cl |&1:0,4,r|
CAS DataBase Reference: 25602-68-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL84089
Product name: Nortropinone hydrochloride
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 50 mg
Price: $208
Updated: 2025/07/31

Sigma-Aldrich

Product number: CDS021991
Product name: Nortropinone hydrochloride
Packaging: 100mg
Price: $42.8
Updated: 2025/07/31

TCI Chemical

Product number: N0844
Product name: Nortropinone Hydrochloride
Purity: >98.0%(T)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TCI Chemical

Product number: N0844
Product name: Nortropinone Hydrochloride
Purity: >98.0%(T)
Packaging: 25g
Price: $343
Updated: 2025/07/31

Usbiological

Product number: 285390
Product name: Nortropinone hydrochloride
Packaging: 500mg
Price: $425
Updated: 2021/12/16

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Nortropinone hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

Nortropinone hydrochloride is a metabolite of Tropinone. It is also used as an inhibitor in reactions that involve 11 beta-hydroxysteroid dehydrogenase type 1 enzyme. It plays an important role in the process of drug discovery, as it is an excellent linker component or building block and is useful in exploring a vast range of therapeutics and drugs.

Synthesis

532-24-1

25602-68-0

1. 8-Methyl-8-azabicyclo[3.2.1]octan-3-one (tropinone, 10.0 g, 71.84 mmol) was dissolved in dichloroethane (DCE, 60 mL), and 1-chloroethyl chloroformate (ACE-C1, 14.5 mL, 19.11 g, 133.7 mmol) was slowly added dropwise. The reaction mixture was stirred at room temperature overnight and subsequently diluted with ether (Et2O, 400 mL) and filtered. The filtrate was concentrated under reduced pressure to give crude chloroethyl carbamate. 2. The above crude product was dissolved in methanol (MeOH, 200 mL) and stirred at room temperature for 1 h. Subsequently, it was concentrated under reduced pressure at 55 °C to obtain crude desmethyltropinone hydrochloride (brown solid, 11.4 g, 98% yield). 3. The crude product was recrystallized by acetonitrile to afford purified demethyltophenone hydrochloride (white crystalline solid, 5 g, 43% yield). 4. Demethyltophenone (5.10 g, 31.55 mmol) was dissolved in dichloromethane (CH2Cl2, 50 mL) and benzyl chloroformate (4.29 mL, 5.11 g, 29.98 mmol) and diisopropylethylamine (DIPEA, 16.48 mL, 12.23 g, 94.66 mmol) were added slowly and dropwise (note exothermic reaction). The reaction mixture was stirred at room temperature for 30 min and subsequently diluted with dichloromethane (100 mL). The organic phase was washed with 1N hydrochloric acid (2 x 100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product (7.2 g, 88% yield).

References

[1] Patent: WO2006/23852, 2006, A2. Location in patent: Page/Page column 84
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1817 - 1820
[3] Patent: WO2010/126163, 2010, A1. Location in patent: Page/Page column 38
[4] Patent: WO2007/100670, 2007, A1. Location in patent: Page/Page column 47

Nortropinone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Nortropinone hydrochloride Suppliers

Americas 1 Canada 1 China 177 Europe 1 France 1 Germany 2 India 4 Japan 2 Switzerland 1 United Kingdom 4 United States 24 Global 218

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View Lastest Price from Nortropinone hydrochloride manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: Nortropinone hydrochloride 25602-68-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-10-22

Hebei Yanxi Chemical Co., Ltd.

Product: Nortropinone HCl 25602-68-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-07

Beijing Mediking Biopharm Co., Ltd

Product: Nortropinone HCl 25602-68-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2 t
Release date: 2023-11-01

25602-68-0, Nortropinone hydrochlorideRelated Search:

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NORTROPINONE HCL

NORTROPINONE HYDROCHLORIDE

8-Azabicyclo[3.2.1]octan-3-one hydrochloride

3-Nortropanone Hydrochloride

Desmethyltropinone Hydrochloride

Nortropanone Hydrochloride

Nortropinone hydrochlorride

Nortropinone HCl ,98%

(1S,5R)-8-Azabicyclo[3.2.1]octan-3-one hydrochloride

Ntp·HCl

Nortropinone hydrochlorid...

Nortropinone hydrochloride, 8-Aza-3-oxobicyclo[3.2.1]octane hydrochloride

3-Nortropanone Hydrochloride 8-Azabicyclo[3.2.1]octan-3-one Hydrochloride

Nortropinone hydrochloride, 3-Oxo-8-azabicyclo[3.2.1]octane hydrochloride

ABLOCK AB-10-5429

Nortropinone hydrochloride, 98+%

(1R,5S)-8-azabicyclo[3.2.1]octan-3-one hydrochloride

NortropinoneHydrochloride&gt

Nortropinone HydrochL

TIANFUCHEM-- 25602-68-0--High purity Nortropinone hydrochloride in stock

Racemic-8-azabicyclo[3.2.1]octan-3-one hydrochloride

8-azabicyclo[3.2.1]octan-3-one hydrochloride (Nortropinone hydrochloride)

8-?Azabicyclo[3.2.1]?octan-?3-?one, hydrochloride (1:1)

Nortropinone hydrochloride , Nortropinone HCl

Nortropinone hydroehloride

Nortropenone hydrochloride

Tropicanol

25602-68-0

C7H12NOCl

Heterocycle

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Building Blocks/Intermediates

Various Intermediates

Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals

pharmacetical