4,6-Dichloroquinazoline

Application

Product Name: 4,6-Dichloroquinazoline
CAS No.: 7253-22-7
Chemical Name: 4,6-Dichloroquinazoline
Synonyms: 6-dichloroquinazoline;4,6-DICHLOROQUINAZOLINE;Quinazoline, 4,6-dichloro-
CBNumber: CB2759151
Molecular Formula: C8H4Cl2N2
Formula Weight: 199.04
MOL File: 7253-22-7.mol

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4,6-Dichloroquinazoline Property

Melting point:: 155-156 °C
Boiling point:: 305.7±22.0 °C(Predicted)
Density: 1.486±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.11±0.30(Predicted)
Appearance: Off-white to yellow Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S658367
Product name: 4,6-DICHLOROQUINAZOLINE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $113
Updated: 2025/07/31

Sigma-Aldrich

Product number: S658367
Product name: 4,6-DICHLOROQUINAZOLINE
Purity: AldrichCPR
Packaging: 25MG
Price: $110
Updated: 2024/03/01

TRC

Product number: D438490
Product name: 4,6-Dichloroquinazoline
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D438490
Product name: 4,6-Dichloroquinazoline
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 072010
Product name: 4,6-Dichloroquinazoline
Purity: 95+%
Packaging: 1g
Price: $76
Updated: 2021/12/16

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4,6-Dichloroquinazoline Chemical Properties,Usage,Production

Application

4,6-Dichloroquinazoline is widely used due to its high pharmacological activity and diverse biological activities. It possesses two carbon-nitrogen double bonds and is widely found in various alkaloids and organic molecules with biopharmacological activity. Its activities include antitumor, antimalarial, anti-inflammatory, antibacterial, anticonvulsant, antituberculosis, and antihypertensive effects.

Synthesis

16064-14-5

7253-22-7

General procedure for the synthesis of 4,6-dichloroquinazoline from 6-chloroquinazolin-4-one: 6-chloroquinazolin-4-one (400 mg, 2.21 mmol, 1.0 eq.), phosphoryl chloride (1.99 mL, 21.4 mmol, 9.64 eq.) and triethylamine (0.99 mL, 7.11 mmol, 3.21 eq.) were mixed under nitrogen protection in a reaction flask. The reaction mixture was stirred and refluxed for 2.5 hours at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporation and the residue was recrystallized twice with toluene to give a brown solid. The solid was dissolved in dichloromethane (25 mL) and the organic phase was washed twice with saturated ammonium chloride solution (25 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated to give a brown solid. The crude product was purified by silica gel column chromatography with an eluent of 9:1 to 3:1 hexane/ethyl acetate to give 4,6-dichloroquinazoline (300 mg) as an off-white solid in 68% yield. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 9.16 (s, 1H), 8.33 (s, 1H), 8.17 (apparent t, 2H, J = 7 Hz).

References

[1] Patent: WO2015/164374, 2015, A1. Location in patent: Paragraph 00349; 00351
[2] Oriental Journal of Chemistry, 2010, vol. 26, # 4, p. 1401 - 1406
[3] Patent: US2005/54626, 2005, A1. Location in patent: Page/Page column 38
[4] Patent: WO2016/91774, 2016, A1. Location in patent: Page/Page column 21
[5] Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982, vol. 37, # 7, p. 907 - 911

4,6-Dichloroquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-Dichloroquinazoline Suppliers

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View Lastest Price from 4,6-Dichloroquinazoline manufacturers

Career Henan Chemical Co

Product: 4,6-Dichloroquinazoline 7253-22-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-03

7253-22-7, 4,6-DichloroquinazolineRelated Search:

CHLOROQUINE Cefazolin sodium salt 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Cefazolin Oxymetazoline hydrochloride 2,4-DICHLOROQUINAZOLINE 6-Methoxy-2,4-dichloroquinazoline 4,7-DICHLOROQUINAZOLINE 7-Fluoro-2,4-dichloroquinazoline 8-Methoxy-2,4-dichloroquinazoline 4,8-DICHLORO-QUINAZOLINE 4,5-Dichloroquinazoline 6-BROMO-2,4-DICHLOROQUINAZOLINE Quinazoline 4,6-DICHLORO-2-(TRIFLUOROMETHYL)QUINAZOLINE 4,6-DICHLORO-2-(4-CHLORO-PHENYL)-QUINAZOLINE 4,6,8-TRICHLOROQUINAZOLINE 2,4,6,8-TETRACHLOROQUINAZOLINE

4,6-DICHLOROQUINAZOLINE

6-dichloroquinazoline

Quinazoline, 4,6-dichloro-

7253-22-7

Halides

Heterocycles