Broxuridine

ChemicalBook > CAS DataBase List > Broxuridine

Product Name: Broxuridine
CAS No.: 59-14-3
Chemical Name: Broxuridine
Synonyms: BDU;bromodeoxyuridine;5-BRDU;BUDR;BRUDR;BR-DU;5-bdu;5-budr;radibud;5-BrdU5G
CBNumber: CB2775230
Molecular Formula: C9H11BrN2O5
Formula Weight: 307.1
MOL File: 59-14-3.mol

Less

Broxuridine Property

Melting point:: 191-194 °C (dec.)(lit.)
alpha: 31 º (c=1, 0.1N NaOH)
Density: 1.8573 (rough estimate)
refractive index: 22 ° (C=1, H2O)
storage temp.: -20°C
solubility: NH₄OH: 0.1 M at 20 °C, clear, colorless
pka: 7.73±0.10(Predicted)
form: Crystals or Crystalline Powder
color: White to yellow
Water Solubility: 1-5 g/100 mL at 22 ºC
Merck: 14,1452
BRN: 30395
Stability:: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChIKey: XMJRLEURHMTTRX-UHFFFAOYSA-N
LogP: -0.290
CAS DataBase Reference: 59-14-3(CAS DataBase Reference)
EPA Substance Registry System: Uridine, 5-bromo-2'-deoxy- (59-14-3)

Less

Safety

Hazard Codes: Xn,T
Risk Statements: 68-36/37/38-63-46-24-61
Safety Statements: 36/37/39-26-53-45-36
WGK Germany: 2
RTECS: YU7350000
F: 10-23
TSCA: Yes
HS Code: 29349990
Hazardous Substances Data: 59-14-3(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H340May cause genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B5002
Product name: 5-Bromo-2′-deoxyuridine
Purity: ≥99% (HPLC)
Packaging: 1g
Price: $151
Updated: 2024/03/01

Sigma-Aldrich

Product number: B5002
Product name: 5-Bromo-2′-deoxyuridine
Purity: ≥99% (HPLC)
Packaging: 5g
Price: $598
Updated: 2024/03/01

Sigma-Aldrich

Product number: 203806
Product name: 5-Bromo-2ʹ-deoxyuridine - CAS 59-14-3 - Calbiochem
Purity: Thymidineanalog.UsefulforthestudyofDNAsynthesiswhereitisincorporated
Packaging: 1g
Price: $241
Updated: 2024/03/01

Sigma-Aldrich

Product number: 203806
Product name: 5-Bromo-2ʹ-deoxyuridine - CAS 59-14-3 - Calbiochem
Purity: Thymidineanalog.UsefulforthestudyofDNAsynthesiswhereitisincorporated
Packaging: 5G
Price: $758
Updated: 2024/03/01

Sigma-Aldrich

Product number: 10280879001
Product name: 5-Bromo-2′-deoxyuridine
Packaging: 1g
Price: $119
Updated: 2024/03/01

Less

Broxuridine Chemical Properties,Usage,Production

Description

5-Bromo-2'-deoxyuridine is a nitrate reductase inhibitor that prevents the reduction of nitrate to nitrite by inhibiting the enzyme nitrate reductase. 5-Bromo-2'-deoxyuridine is a genotoxic agent that has been shown to cause DNA damage and cell death in vitro. 5-Bromo-2'-deoxyuridine also binds to NMDA receptors and may be useful as a model system for studying neurodegenerative diseases.

Chemical Properties

White crystalline powder

Uses

A Thymidine analogue used as a mutagen in genetic research. Selectively incorporated into cellular DNA during S-phase

Uses

Research tool for measuring DNA synthesis.

Uses

5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.

Definition

ChEBI: A pyrimidine 2'-deoxyribonucleoside compound having 5-bromouracil as the nucleobase.

General Description

White crystalline powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

Broxuridine may be heat and light sensitive. .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Broxuridine emits very toxic fumes of bromide ion and NOx.

Fire Hazard

Flash point data for Broxuridine are not available; however, Broxuridine is probably combustible.

Biological Activity

5-bromodeoxyuridine (5-brdu) is an analog of thy that is incorporated into the dna of cells undergoing the s-phase and can be detected by monoclonal antibodies or polyclona111.

Biochem/physiol Actions

5-Bromo-2′-deoxyuridine (BrdU) is used to analyze cell proliferation, because of its facile incorporation into DNA during the S phase of the cell cycle. BrdU stimulates cellular differentiation and maturation in leukemia cell lines, while it inhibits differentiation of friend erythroleukemia cells. Studies of BrdU incorporation often subsequently use BrdU-specific antibodies with fluorescent tags, for detection of the incorporated BrdU, via such methods as flow cytometry or fluorescence microscopy.

Safety Profile

Moderately toxic by subcutaneous, intravenous, intraperitoneal, and possibly other routes. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Brand NOx

in vitro

the effect of 5-brdu on the proliferation was studied in the early phases of dedifferentiation of nicotiana glauca pith explants grown. it was found to be wholly inhibitory only when given during the first 72 h of culture, this inhibition being reversed by simultaneous addition of either deoxyeytidine or thymidine [1].

in vivo

young adult offspring mice were stained for 5-brdu using a monoclonal antibody and the peroxidase-antiperoxidase method. the distribution of immunoreactive nuclei was very similar to the previous [3h] thymidine data. the pattern of labelled nuclei at different embryonic ages followed the spatiotemporal gradients described for cortical and hippocampal neurogenesis. these data indicate that brdu can be used to map neuronal birthdates [2].

storage

-20°C

Purification Methods

Recrystallise the uridine from EtOH or 96% EtOH. It has max 279 nm at pH 7.0, and 279 nm (log 3.95) at pH 1.9. Its RF values are 0.49, 0.46 and 0.53 in n-BuOH/AcOH/H2O (4:1:1), n-BuOH/EtOH/H2O (40:11:19) and i-PrOH-25% aqueous NH3-H2O (7:1:1), respectively. [Nature 209 230 1966, Pryst.s & Sorm Collect Czech Chem Comm 29 2956 1964, Beilstein 24 III/IV 1234.]

References

[1] m. durante, c. geri, v. nuti-ronchi, g. martini, e. guillé, j. grisvard, l. giorgi, r. parenti, m. bulatti. inhibition of nicotiana glauca pich tissue proliferation through incorporation of 5-brdu into sna. cell differentiation, volume 6, issue 1, june 1977, pages 53-63
[2] del rio ja, soriano e. immunocytochemical detection of 5'-bromodeoxyuridine incorporation in the central nervous system of the mouse. brain res dev brain res. 1989 oct 1; 49 (2): 311-7.

Broxuridine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Broxuridine Suppliers

Americas 1 Belgium 1 Canada 3 China 249 Czech 1 Europe 3 France 2 Germany 8 Hungary 1 India 13 Italy 1 Japan 4 Poland 1 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 13 United States 73 Global 379

Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-8233716 18055326116
Email: sales@nuowei-chem.com
Country: China
ProdList: 951
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Hongene Biotech Corporation

Tel: 021-64757213
Fax: 86-21-64700613
Email: info@hongene.com
Country: China
ProdList: 672
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

Nanjing Search Biotech Co., Ltd

Tel: +86-025-81682922 +86-13515111588
Fax: 025-85860962
Email: sales@searchbio.com.cn
Country: China
ProdList: 135
Advantage: 68

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-0553-0553-5842013-801-801 18155347026
Fax: 086-553-5843138
Email: jinhuaren@huarensh.com
Country: China
ProdList: 295
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sphchem Co., Ltd.

Tel: 21-21-56491756 13512199871
Fax: 021-5649-1756
Email: sales@panhongchem.com
Country: China
ProdList: 4000
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Nanjing Asian Chemical Co., Ltd.

Tel: +86 (25) 82263158
Fax: +86 (25) 82263168
Country: China
ProdList: 262
Advantage: 60

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9978
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Shanghai DiBai Chemicals Co., Ltd.

Tel: 021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3991
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

MP Biomedicals

Tel: 400-1500-680 021-62402299
Fax: 021-62402299
Email: nancy.cai@mpbio.com
Country: China
ProdList: 125
Advantage: 60

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Shanghai CanSpecsci Instrument Co., Ltd.

Tel: 400-6087598 15021221957
Fax: 4006087598-8012
Email: order@canspecsci.com
Country: China
ProdList: 2045
Advantage: 56

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 7295
Advantage: 60

NINGBO INNO PHARMCHEM CO.,LTD.

Tel: 86-574-27787657
Fax: 86-574-27912196
Email: info@dearchem.com
Country: China
ProdList: 4613
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10276
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11481
Advantage: 59

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 13096311329 028-88469284 616445927
Fax: 028-88469284
Email: 616445927@qq.com
Country: China
ProdList: 2874
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Less

View Lastest Price from Broxuridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Bromo-2'-deoxyuridine 59-14-3
Price: US $0.00-0.00/KG
Min. Order: 100g
Purity: 98%min
Supply Ability: 100kgs
Release date: 2021-09-07

Hebei Weibang Biotechnology Co., Ltd

Product: Broxuridine 59-14-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Hebei Mojin Biotechnology Co., Ltd

Product: Broxuridine 59-14-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-10-11

59-14-3, BroxuridineRelated Search:

Trifluridine UMP 1-beta-D-Arabinofuranosyluracil Doxifluridine 2'-Deoxyuridine Bromocresol Purple Dimidium bromide Ethidium bromide Bromocresol green 1-Bromohexane Cyanogen bromide 5-Bromouridine 5-Bromo-2'-deoxy-5'-uridylic acid disodium salt 5-Bromouracil Uridine Uracil Bromine BrdU (Bromodeoxyuridine)

5-BROMO-1-(2-DEOXY-BETA-D-RIBOFURANOSYL)URACIL

5-BRDU

5-BROMO DEOXYURIDINE

5-BROMO-2'-DESOXYURIDINE

(+)-5-BROMO-2'-DEOXYURIDINE

5-BROMO-2'-DEOXYURIDINE

5-budr

bromodeoxyuridine

bromouracildeoxyriboside

5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil

5-BROMO-2'-DEOXYURIDINE SIGMAULTRA

5-Bromodeoxyuridine,Crystalline,>98%

Bromo-2'-deoxyuridine

5-Bromo-2'-deoxy-D-uridine

5-BROMO-2-DEOXYURIDINE,ULTRAPURE

5-BROMO-2''-DEOXYURIDINE(5-BRDU)

BROMO-2'-DEOXYURIDINE, 5-(RG)

5-Bromo-2'-deoxyuridine, 99+%

BROMODESOXYURIDINE

5-BROMO-2''-DEOXYURIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM

5-BROMO-2''-DEOXYURIDINE CRYSTALLINE

BrdU [5-Bromo-2'-deoxyuridine] *CAS 59-14-3*

5-BrdU5G

Bromodeoxyuridine Cell Proliferation Kit, BioAssay&trade

5-bromo-2-deoxyuridine (BrdU)

5-Bromo-1-(2-deoxy-&beta

-D-ribofuranosyl)uracil

BUDR

BROMO-2'-DEOXYURIDINE,5-

BRUDR

BROXURIDINE

BR-DU

BRDU LABELING REAGENT

BDU

CHEMPACIFIC 52436

5-BROMO-2-DEOXYURIDINE extrapure

5-BrdU, 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil, 5-Bromouracil deoxyriboside, BUdR

1-(2-deoxy-β-D-ribofuranosyl)-5-bromouracil

5-bdu

5-bromodesoxyuridine

5-bromouracil-2-deoxyriboside

5-bromouracildeoxyriboside

5''-BROMODEOXYURIDINE (BROXURIDINE)

2'-DEOXY-5-BROMOROURIDINE

2'-DEOXY-5-BROMOURIDINE

NSC-3829

radibud

5-Bromo-2’-deoxyridine

5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uraci

5-Brdu, 5-Bromo-2'-deoxyuridine

(+)-5-BroMo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]pyriMidine-2,4-dione

NSC 38297

5-Br-2'--dU

5-Bromo-1-(2-deoxy-beta-D-ribofuranosyl)uracil 5-BrdU BUdR

l 5-Bromouracil deoxyriboside

5-Bromo-2′-deoxyuridine,5-BrdU, 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil, 5-Bromouracil deoxyriboside, BUdR

5-broMo-1-[(2S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione

5-BroMo-3-deoxyuridine