Narsoplimab

Product Name: Narsoplimab
CAS No.: 2108782-45-0
Chemical Name: Narsoplimab
Synonyms: OMS 721;Narsoplimab;Narsoplimab (anti-MASP2);Research Grade Narsoplimab;Research Grade Narsoplimab(DHA04501)
CBNumber: CB28081065
Formula Weight: 0
MOL File: Mol file

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Narsoplimab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Narsoplimab Chemical Properties,Usage,Production

Uses

Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2[1].

in vivo

Narsoplimab (10 mg/kg; i.v.; WT and Masp2^-/- (KO) mice) decreases percentage of lymphocytes (Lym%) and increases percentage of neutrophils (Neu%)^[1].

Animal Model:	WT and Masp2^-/- (KO) mice (C57BL/6N, female, 12-15 weeks old)^[1]
Dosage:	10 mg/kg
Administration:	Intravenous injection
Result:	Decreased percentage of lymphocytes (Lym%) and an increased percentage of neutrophils (Neu%).

References

[1] Gao T, et, al. Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation. Signal Transduct Target Ther. 2022 Sep 14;7(1):318. DOI:10.1038/s41392-022-01133-5

Narsoplimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Narsoplimab Suppliers

China 20 United States 2 Global 22

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2108782-45-0, NarsoplimabRelated Search:

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Narsoplimab

Research Grade Narsoplimab(DHA04501)

Narsoplimab (anti-MASP2)

OMS 721

Research Grade Narsoplimab

2108782-45-0