Doramapimod

Product Name: Doramapimod
CAS No.: 285983-48-4
Chemical Name: Doramapimod
Synonyms: BIRB 796 (DoraMapiMod);CS-379;CS-1863;BIBR-796;BIRB 796;BIRB 796BS;doramapimod;BIRB-796;BIRB796;DoraMapin BIBR796;BIBR-796(DoraMapiMod)
CBNumber: CB2855127
Molecular Formula: C31H37N5O3
Formula Weight: 527.66
MOL File: 285983-48-4.mol

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Doramapimod Property

Melting point:: 142-143 °C
Boiling point:: 631.6±55.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
form: solid
pka: 13.47±0.70(Predicted)
color: White or off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 506172
Product name: p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 10460
Product name: Doramapimod
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 10460
Product name: Doramapimod
Purity: ≥98%
Packaging: 5mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 10460
Product name: Doramapimod
Purity: ≥98%
Packaging: 10mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 10460
Product name: Doramapimod
Purity: ≥98%
Packaging: 25mg
Price: $153
Updated: 2024/03/01

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Doramapimod Chemical Properties,Usage,Production

Description

Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1?(IC50=18 nM). Displays anti-inflammatory activity2?but differential effects on inflammatory genes3. Cell permeable.

Chemical Properties

Pale Beige Solid

Uses

Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.

Definition

ChEBI: A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.

in vitro

birb 796 is a picomolar inhibitor of human p38 map kinase with a 12,000-fold increase in binding affinity. moreover, birb 796 behavors as one of the most potent and slowest dissociating human p38 map kinase inhibitors now known [1].

in vivo

in a lps-stimulated tnf-α synthesis mouse model, a 65% inhibition of tnf-α synthesis was observed when birb 796 was dosed orally at 10 mg/kg. in a model of established collagen-induced arthritis using b10.riii mice, birb 796 showed a 63% inhibition of arthritis severity when dosed orally at 30 mg/kg qd [2].

storage

Store at -20°C

References

1) Pargellis?et al. (2002),?Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol.,?9?268 2) Branger?et al.?(2002),?Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol.,?168?4070 3) Joos?et al. (2010),?Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytes; Br. J. Pharmacol.,?160?1252

Doramapimod Preparation Products And Raw materials

Raw materials

Preparation Products

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Doramapimod Suppliers

Canada 1 China 149 India 2 The Netherlands 1 United Kingdom 3 United States 19 Global 175

AdooQ BioScience, LLC

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HBCChem, Inc.

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Target molecule Corp.

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Musechem

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InvivoChem

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Cckinase, Inc.

Tel: +1 (732)236-3202
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Alchem Pharmtech,Inc.

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Aladdin Scientific

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View Lastest Price from Doramapimod manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Doramapimod 285983-48-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Doramapimod 285983-48-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: Doramapimod 285983-48-4
Price: US $3.00/KG
Min. Order: 3KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-08-26

285983-48-4, DoramapimodRelated Search:

Cyhalofop-butyl Diethylene glycol monobutyl ether Moroxydine hydrochloride Butylnaphtalenesulfonic Acid Sodium Salt tert-Butanol tert-Butylchlorodiphenylsilane Buprofezin 2-Butoxyethanol Tridemorph Moroxydine Butyl acetate Butyl acrylate Dimethomorph MORPHINE 5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-ylamine 4-(2-MORPHOLIN-4-YLETHOXY)ANILINE 4-(2-Morpholinoethoxy)naphthalen-1-amine BIRB 796 (Doramapimod)

1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea

1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea

BIRB 796; BIRB-796; BIRB796;

CS-379

BIRB 796 - BIRB 0796 | Doramapimod

CS-1863

BIBR-796

1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea

DoraMapiMod, BIBR-796

BIBR-796(DoraMapiMod)

BIRB 796 (DoraMapiMod)

BIRB 796BS

N-[3-(1,1-DiMethylethyl)-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]urea

DoraMapin BIBR796

DoraMapiMod (BIRB-796)

BIRB 796

doramapimod

Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-

1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea BIRB 796 (Doramapimod)

Doramapimod 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea

DORAMAPIMOD;BIRB 796;BIRB796

3-[3-Tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea

1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea

1-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1h-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea

BIRB-796;BIRB796

Doramapimod USP/EP/BP

p38 MAP Kinase Inhibitor X BIRB-796 Doramapimod

1-[3-(tert-Butyl)-1-(p-tolyl)-5-pyrazolyl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea

Doramapimod, p38 MAPK inhibitor

Doramapimod, 10 mM in DMSO

285983-48-4

C31H37N5O3

Anti-cancer&immunity

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Protein Kinase Inhibitors and Activators

MAPK

Inhibitors