alpha-methoxy-p-cresol
- Product Name
- alpha-methoxy-p-cresol
- CAS No.
- 5355-17-9
- Chemical Name
- alpha-methoxy-p-cresol
- Synonyms
- α-methoxy-p-cresol;alpha-methoxy-p-cresol;p-(MethoxyMethyl)phenol;4-(Methoxymethyl)phenol;alpha-methoxy-para-cresol;Phenol, 4-(methoxymethyl)-;(4-Hydroxybenzyl)methyl ether;alpha-Methoxy-p-cresol Phenol;4-(2-METHOXYETHYL)PHENOLMETHOTREATE
- CBNumber
- CB2939991
- Molecular Formula
- C8H10O2
- Formula Weight
- 138.16
- MOL File
- 5355-17-9.mol
alpha-methoxy-p-cresol Property
- Melting point:
- 82.5-83.5 °C
- Boiling point:
- 147-153 °C(Press: 11 Torr)
- Density
- 1.5319 g/cm3(Temp: 24 °C)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 9.84±0.26(Predicted)
- InChI
- InChI=1S/C8H10O2/c1-10-6-7-2-4-8(9)5-3-7/h2-5,9H,6H2,1H3
- InChIKey
- AHXXIALEMINDAW-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(COC)C=C1
- LogP
- 1.190 (est)
- EPA Substance Registry System
- Phenol, 4-(methoxymethyl)- (5355-17-9)
Safety
- HS Code
- 2909500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CHM0095350
- Product name
- 4-(METHOXYMETHYL)PHENOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $626.24
- Updated
- 2021/12/16
- Product number
- CHM0095350
- Product name
- 4-(METHOXYMETHYL)PHENOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $839.99
- Updated
- 2021/12/16
- Product number
- CHM0095350
- Product name
- 4-(METHOXYMETHYL)PHENOL
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1175.01
- Updated
- 2021/12/16
- Product number
- 5355179
- Product name
- 4-(Methoxymethyl)phenol
- Packaging
- 5g
- Price
- $696.46
- Updated
- 2021/12/16
- Product number
- CM117091
- Product name
- 4-(Methoxymethyl)phenol
- Purity
- 95+%
- Packaging
- 10g
- Price
- $739
- Updated
- 2021/12/16
alpha-methoxy-p-cresol Chemical Properties,Usage,Production
Definition
ChEBI: 4-(methoxymethyl)phenol is a member of the class of phenols that is p-cresol in which one of the methyl hydrogens has been replaced by a methoxy group. It has a role as a plant metabolite.
Synthesis Reference(s)
Tetrahedron Letters, 30, p. 1939, 1989 DOI: 10.1016/S0040-4039(00)99619-9
Synthesis
67-56-1
623-05-2
5355-17-9
Under nitrogen protection, 3.96 g (0.03 mol) of p-hydroxybenzyl alcohol (purchased from Tokyo Chemical Industry Co., Ltd.) was added to a 100 mL three-necked flask equipped with a thermometer, a three-way stopper and a magnetic stirrer, followed by 21 g of methanol (purchased from Nacalai Tesque, Inc.) and two drops of nitromethane (purchased from Nacalai Tesque, Inc.). Under stirring conditions at room temperature, 0.2 g of hydrochloric acid (purchased from Nacalai Tesque, Inc.) was slowly added dropwise, followed by continuous stirring of the reaction mixture for 5 h at 30 °C. The reaction mixture was then analyzed by HPLC. Upon completion of the reaction, HPLC analysis showed 95% area percentage of the target product 4-methoxymethylphenol. To the reaction system, 0.28 g of pyridine (purchased from Nacalai Tesque, Inc.) and 8 g of toluene (purchased from Nacalai Tesque, Inc.) were added for neutralization, followed by concentration under reduced pressure to remove methanol. To the residue 31 g of toluene and 6 g of water were added for extraction and the organic phase was washed with 5 g of water. The resulting organic layer was concentrated, cooled to below 10 °C, and the precipitated crystals were filtered and dried to give 3.53 g (yield: 80%) of colorless crystalline 4-methoxymethylphenol. It was analyzed by HPLC and its purity was 99% (excluding the solvent toluene).
References
[1] Journal of Chemical Research - Part S, 2000, # 6, p. 266 - 268
[2] Journal of Chemical Research - Part S, 2000, # 6, p. 266 - 268
[3] Chemical and pharmaceutical bulletin, 2002, vol. 50, # 3, p. 380 - 383
[4] Patent: JP5747348, 2015, B2. Location in patent: Paragraph 0058-0062; 0066-0070
[5] Journal of Organic Chemistry, 1988, vol. 53, # 18, p. 4263 - 4273
alpha-methoxy-p-cresol Preparation Products And Raw materials
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View Lastest Price from alpha-methoxy-p-cresol manufacturers
- Product
- alpha-methoxy-p-cresol 5355-17-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-14
- Product
- 4-(methoxymethyl)phenol;4-(Methoxymethyl)phenol ;alpha-Methoxy-p-cresol Phenol 5355-17-9
- Price
- US $3.00/KG
- Min. Order
- 10G
- Purity
- ada@tuskwei.com whatsapp;+008617197824028 sky;17197824028
- Supply Ability
- 6000g/day
- Release date
- 2018-01-23