UCN-01

ChemicalBook > CAS DataBase List > UCN-01

Product Name: UCN-01
CAS No.: 112953-11-4
Chemical Name: UCN-01
Synonyms: UNC 01;UCN-01;KW-2401;KRX-0601;NSC 638850;UCN01,UCN 01;KRX-0601，UCN-01;7-hydroxystaurosporine;(5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa;(9S)-2,3,10,11,12,13-Hexahydro-3α-hydroxy-10α-methoxy-9-methyl-11α-methylamino-9β,13β-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
CBNumber: CB2972499
Molecular Formula: C28H26N4O4
Formula Weight: 482.53044
MOL File: 112953-11-4.mol

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UCN-01 Property

Boiling point:: 705.7±60.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >5mg/mL
form: Tan solid
pka: 12.25±0.70(Predicted)
color: light yellow
optical activity: [α]20/D 130 to 160°, c = 0.2 in DMSO

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Safety

WGK Germany: 3
RTECS: KC6600010
Toxicity: mouse,LD50,intraperitoneal,25mg/kg (25mg/kg),Journal of Antibiotics. Vol. 42, Pg. 571, 1989.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: U6508
Product name: UCN-01
Purity: ≥97% (HPLC), powder
Packaging: 1mg
Price: $228
Updated: 2024/03/01

Sigma-Aldrich

Product number: 539644
Product name: UCN-01
Purity: A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases.
Packaging: 500μg
Price: $245
Updated: 2024/03/01

Cayman Chemical

Product number: 18130
Product name: UCN-01
Purity: ≥95%
Packaging: 1mg
Price: $179
Updated: 2024/03/01

Sigma-Aldrich

Product number: U6508
Product name: UCN-01
Purity: ≥97% (HPLC), powder
Packaging: 5mg
Price: $895
Updated: 2024/03/01

ApexBio Technology

Product number: C4783
Product name: UCN-01
Packaging: 1mg(solution)
Price: $215
Updated: 2021/12/16

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UCN-01 Chemical Properties,Usage,Production

Description

UCN-01 is a synthetic derivative of staurosporine with antiproliferative activity against several in vitro and in vivo cancer models. It inhibits a variety of kinases, including Akt, protein kinase C (IC₅₀ = 30 nM), PDK1 (IC₅₀ = 6 nM) and cyclin-dependent kinases (IC₅₀s = 300-600 nM for Cdk1 and Cdk2). UCN-01 arrests tumor cells in the G₁/S phase of the cell cycle and prevents nucleotide excision repair by inhibiting the G₂ checkpoint kinase Chk1 (IC₅₀ = 7 nM), leading to apoptosis.

Uses

UCN-01 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-01 inhibits protein kinase C (PKC) and cyclin-dependant kinase 2 (CDK2), resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by the latter agents.

Uses

UCN 01 is a protein kinase C inhibitor which overrides ZEB1-induced chemoresistance in hepatocellular cancer in human. A cell-permeable Staurosporine derived anticancer agent that inhibits several protein kinases.

General Description

A cell-permeable Staurosporine (Cat. No. 569397) derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases (IC₅₀ = 29 nM, 34 nM, 30 nM, 590 nM and 530 nM for PKCα, PKCβ, PKCγ, PKCδ and PKCε; IC₅₀ = 7 nM, 27 nM, 50 nM, 50 nM, 150 nM and 1.04 M for Chk1, Cdc25C-associated protein kinase 1, Cdk1, PAK4, Cdk5/p25 and Chk2; IC₅₀ = 33 nM, 50 nM, 95 nM, 500 nM, 500 nM and 1.0 M for PDK1, lck, MAPKAP kinase-2, Akt, GSK-3β and PKA, respectively). At higher concentrations (>15 M), affects the activities of Src, PIM-1, CKII, DNA-PK, ErK1, ILK-1 and MAPKK1). Reported to suppress thymidylate synthase expression, induce apoptosis with caspase activation, and sensitize tumor cells to a range of DNA-damaging agents.

Biochem/physiol Actions

Cell permeable: yes

UCN-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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UCN-01 Suppliers

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112953-11-4, UCN-01Related Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Ferric acetylacetonate METHYL ISOCYANOACETATE SALCOMINE COBALT(II) ACETYLACETONATE Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE Aluminum acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) PHENYLSELENOL Benzyl isocyanide Tosylmethyl isocyanide Ethyl isocyanoacetate Cupric acetylacetonate TERT-BUTYL ISOCYANIDE

UCN-01

7-hydroxystaurosporine

KW-2401

(9S)-2,3,10,11,12,13-Hexahydro-3α-hydroxy-10α-methoxy-9-methyl-11α-methylamino-9β,13β-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lM]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-Methoxy-9-Methyl-11-(MethylaMino)-, (3R,9S,10R,11R,13R)-

KRX-0601

NSC 638850

UNC 01

(5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa

(5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14(5H)-one

KRX-0601，UCN-01

UCN01,UCN 01

(3R,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo1,2,3-gh:3',2',1'-lMpyrrolo3,4-j1,7benzodiazonin-1-one

112953-11-4