CRF (BOVINE)
- Product Name
- CRF (BOVINE)
- CAS No.
- 92307-52-3
- Chemical Name
- CRF (BOVINE)
- Synonyms
- CRF;CRH;CRF (BOVINE);PubChem ID: 71581479;CRF (BOVINE) USP/EP/BP;Bovine ACTH-releasing factor;CORTICOTROPIN RELEASING FACTOR BOVINE;Cattle corticotropin-releasing horMone;Corticotropin Relasing Factor (bovine);Corticotropin-releasing factor (cattle)
- CBNumber
- CB3116898
- Molecular Formula
- C206H340N60O63S
- Formula Weight
- 4697.333
- MOL File
- 92307-52-3.mol
CRF (BOVINE) Property
- storage temp.
- −20°C
- solubility
- Soluble in DMSO
- form
- Solid
- Sequence
- Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Asn-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- C2671
- Product name
- Corticotropin Releasing Factor bovine
- Purity
- ≥90% (HPLC), Synthetic
- Packaging
- 1mg
- Price
- $725
- Updated
- 2025/07/31
CRF (BOVINE) Chemical Properties,Usage,Production
Uses
CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
Biochem/physiol Actions
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Purification Methods
The extract is purified by ion-exchange on CM-cellulose, desalted, evaporated and lyophilised. Then separate from impurities by gel filtration through Sephadex G-50. [Lande et al. Biochemical Preparations 13 45 1971, Esch et al. Biochem Biophys Res Commun 122 899 1984].
References
[1] Hogg JE, et al. The human neuroblastoma cell line, IMR-32, expresses functional corticotropin-releasing factor receptors. Eur J Pharmacol. 1996 Sep 26;312(2):257-61. DOI:10.1016/0014-2999(96)00470-0
[2] Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. DOI:10.1016/s0014-2999(99)00506-3
[3] Esposito P, et al. Corticotropin-releasing factor (CRF) can directly affect brain microvessel endothelial cells. Brain Res. 2003 Apr 11;968(2):192-8. DOI:10.1016/s0006-8993(03)02237-6
CRF (BOVINE) Preparation Products And Raw materials
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View Lastest Price from CRF (BOVINE) manufacturers
- Product
- CRF (BOVINE) 92307-52-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-14