2-Methanesulfonyl-4,6-dimethoxypyrimidine
- Product Name
- 2-Methanesulfonyl-4,6-dimethoxypyrimidine
- CAS No.
- 113583-35-0
- Chemical Name
- 2-Methanesulfonyl-4,6-dimethoxypyrimidine
- Synonyms
- MSDP;DMMSP;4,6-DIMETHOXY-2-(METHYLSULFONYL)PYRIMIDINE;4,6-DIMETHOXY-2-METHYL-SULFONYLPYRIMIDIME;21158;2-Methanesulfonyl-4;2-Methylsulfonyl-4,6;4,6-dimethoxy-2-mesyl-pyrimidine;4,6-DIMETHOXY-2-(METHYLSULFONYL);DiMethoxy-2-(Methylsulfonyl)pyriM
- CBNumber
- CB3117219
- Molecular Formula
- C7H10N2O4S
- Formula Weight
- 218.23
- MOL File
- 113583-35-0.mol
2-Methanesulfonyl-4,6-dimethoxypyrimidine Property
- Melting point:
- 129-133 °C(lit.)
- Boiling point:
- 412.6±48.0 °C(Predicted)
- Density
- 1.317±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -3.39±0.30(Predicted)
- color
- Whtie
- InChI
- InChI=1S/C7H10N2O4S/c1-12-5-4-6(13-2)9-7(8-5)14(3,10)11/h4H,1-3H3
- InChIKey
- ITDVJJVNAASTRS-UHFFFAOYSA-N
- SMILES
- C1(S(C)(=O)=O)=NC(OC)=CC(OC)=N1
- CAS DataBase Reference
- 113583-35-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 549878
- Product name
- 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
- Purity
- 97%
- Packaging
- 25g
- Price
- $235
- Updated
- 2023/06/20
- Product number
- D3101
- Product name
- 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- D461475
- Product name
- 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
- Packaging
- 100g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 031266
- Product name
- 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
- Purity
- 97%
- Packaging
- 25g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- 43704
- Product name
- 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 5G
- Price
- $159.46
- Updated
- 2021/12/16
2-Methanesulfonyl-4,6-dimethoxypyrimidine Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine may be used in the microwave assisted preparation of 4,6-dimethoxy-N-methylpyrimidin-2-amine by reacting with methylamine. It may also be used to prepare 2′-pyrimidinecarbonylsulfonanilide derivatives with potent herbicidal activity.
Uses
2-Methanesulfonyl-4,6-dimethoxypyrimidine was used to prepare nonpeptidic endothelin-A receptor antagonists.
Preparation
One method for preparing 2-Methanesulfonyl-4,6-dimethoxypyrimidine comprises with 4, 6-dihydroxyl-2-methylthiopyrimidine is a main raw material, and through superchlorination, methoxylation and oxidizing reaction, reaction formula is as follows:
General Description
4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine can be prepared by the oxidation of 2-methylthio-4,6-dimethoxypyrimidine.
Synthesis
90905-46-7
113583-35-0
Example 10: Synthesis of 4,6-dimethoxy-2-(methylsulfonyl)pyrimidine To 200 mL of acetic acid was added 3% sodium tungstate as a catalyst. Subsequently, 1.0 mol of 2-methylsulfanyl-4,6-dimethoxypyrimidine was added to the solution and stirred until completely dissolved to form a clarified solution. The reaction mixture was heated to 40°C. Over a period of 4-8 hours, 2.1 mol of 30% H2O2 solution was slowly added to the heated reaction mixture and stirring was continued at 40 °C for 3-5 hours. After that, 0.05 mol of 30% H2O2 solution was added supplementally and stirring was continued at the same temperature until the reaction was complete (the progress of the reaction was monitored by TLC or HPLC). After completion of the reaction, the reaction mixture was cooled to room temperature and the precipitated solid was collected by filtration. The resulting solid was washed sequentially with aqueous acetic acid and deionized water to remove impurities. Finally, the washed solid was dried under appropriate conditions to obtain the target product in 83% yield. The filtrate portion was extracted with dichloroethane, and after separating the organic layer, the dichloroethane layer was concentrated to give a residue of about 42 g containing a small amount of product in about 1-1.5% yield.
References
[1] Asian Journal of Chemistry, 2014, vol. 26, # 1, p. 313 - 314
[2] Journal of Agricultural and Food Chemistry, 2018, vol. 66, # 15, p. 3773 - 3782
[3] Pesticide Science, 1996, vol. 47, # 2, p. 115 - 124
[4] Patent: WO2014/128719, 2014, A2. Location in patent: Page/Page column 17
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2006, vol. 49, # 4, p. 339 - 343
2-Methanesulfonyl-4,6-dimethoxypyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methanesulfonyl-4,6-dimethoxypyrimidine manufacturers
- Product
- 2-Methanesulfonyl-4,6-dimethoxypyrimidine 113583-35-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-11-25
- Product
- 2-Methylsulfonyl-4,6-dimethoxypyrimidine 113583-35-0
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kgs
- Release date
- 2021-11-16
- Product
- 2-Methylsulfonyl-4,6-dimethoxypyrimidine 113583-35-0
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-12