ChemicalBook > CAS DataBase List > 2-Methanesulfonyl-4,6-dimethoxypyrimidine

2-Methanesulfonyl-4,6-dimethoxypyrimidine

Product Name
2-Methanesulfonyl-4,6-dimethoxypyrimidine
CAS No.
113583-35-0
Chemical Name
2-Methanesulfonyl-4,6-dimethoxypyrimidine
Synonyms
MSDP;DMMSP;4,6-DIMETHOXY-2-(METHYLSULFONYL)PYRIMIDINE;4,6-DIMETHOXY-2-METHYL-SULFONYLPYRIMIDIME;21158;2-Methanesulfonyl-4;2-Methylsulfonyl-4,6;4,6-dimethoxy-2-mesyl-pyrimidine;4,6-DIMETHOXY-2-(METHYLSULFONYL);DiMethoxy-2-(Methylsulfonyl)pyriM
CBNumber
CB3117219
Molecular Formula
C7H10N2O4S
Formula Weight
218.23
MOL File
113583-35-0.mol
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2-Methanesulfonyl-4,6-dimethoxypyrimidine Property

Melting point:
129-133 °C(lit.)
Boiling point:
412.6±48.0 °C(Predicted)
Density 
1.317±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
-3.39±0.30(Predicted)
color 
Whtie
InChI
InChI=1S/C7H10N2O4S/c1-12-5-4-6(13-2)9-7(8-5)14(3,10)11/h4H,1-3H3
InChIKey
ITDVJJVNAASTRS-UHFFFAOYSA-N
SMILES
C1(S(C)(=O)=O)=NC(OC)=CC(OC)=N1
CAS DataBase Reference
113583-35-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
549878
Product name
4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
Purity
97%
Packaging
25g
Price
$235
Updated
2023/06/20
TCI Chemical
Product number
D3101
Product name
4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$68
Updated
2025/07/31
TRC
Product number
D461475
Product name
4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
Packaging
100g
Price
$140
Updated
2021/12/16
Matrix Scientific
Product number
031266
Product name
4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine
Purity
97%
Packaging
25g
Price
$21
Updated
2021/12/16
Chem-Impex
Product number
43704
Product name
4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine,≥98%(GC)
Purity
≥98%(GC)
Packaging
5G
Price
$159.46
Updated
2021/12/16
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2-Methanesulfonyl-4,6-dimethoxypyrimidine Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine may be used in the microwave assisted preparation of 4,6-dimethoxy-N-methylpyrimidin-2-amine by reacting with methylamine. It may also be used to prepare 2′-pyrimidinecarbonylsulfonanilide derivatives with potent herbicidal activity.

Uses

2-Methanesulfonyl-4,6-dimethoxypyrimidine was used to prepare nonpeptidic endothelin-A receptor antagonists.

Preparation

One method for preparing 2-Methanesulfonyl-4,6-dimethoxypyrimidine comprises with 4, 6-dihydroxyl-2-methylthiopyrimidine is a main raw material, and through superchlorination, methoxylation and oxidizing reaction, reaction formula is as follows:

General Description

4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine can be prepared by the oxidation of 2-methylthio-4,6-dimethoxypyrimidine.

Synthesis

90905-46-7

113583-35-0

Example 10: Synthesis of 4,6-dimethoxy-2-(methylsulfonyl)pyrimidine To 200 mL of acetic acid was added 3% sodium tungstate as a catalyst. Subsequently, 1.0 mol of 2-methylsulfanyl-4,6-dimethoxypyrimidine was added to the solution and stirred until completely dissolved to form a clarified solution. The reaction mixture was heated to 40°C. Over a period of 4-8 hours, 2.1 mol of 30% H2O2 solution was slowly added to the heated reaction mixture and stirring was continued at 40 °C for 3-5 hours. After that, 0.05 mol of 30% H2O2 solution was added supplementally and stirring was continued at the same temperature until the reaction was complete (the progress of the reaction was monitored by TLC or HPLC). After completion of the reaction, the reaction mixture was cooled to room temperature and the precipitated solid was collected by filtration. The resulting solid was washed sequentially with aqueous acetic acid and deionized water to remove impurities. Finally, the washed solid was dried under appropriate conditions to obtain the target product in 83% yield. The filtrate portion was extracted with dichloroethane, and after separating the organic layer, the dichloroethane layer was concentrated to give a residue of about 42 g containing a small amount of product in about 1-1.5% yield.

References

[1] Asian Journal of Chemistry, 2014, vol. 26, # 1, p. 313 - 314
[2] Journal of Agricultural and Food Chemistry, 2018, vol. 66, # 15, p. 3773 - 3782
[3] Pesticide Science, 1996, vol. 47, # 2, p. 115 - 124
[4] Patent: WO2014/128719, 2014, A2. Location in patent: Page/Page column 17
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2006, vol. 49, # 4, p. 339 - 343

2-Methanesulfonyl-4,6-dimethoxypyrimidine Preparation Products And Raw materials

Raw materials

Pyramat Sodium Methoxide

Preparation Products

Bispyribac-sodium Pyribenzoxim
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2-Methanesulfonyl-4,6-dimethoxypyrimidine Suppliers

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View Lastest Price from 2-Methanesulfonyl-4,6-dimethoxypyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Methanesulfonyl-4,6-dimethoxypyrimidine 113583-35-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-11-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Methylsulfonyl-4,6-dimethoxypyrimidine 113583-35-0
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kgs
Release date
2021-11-16
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-Methylsulfonyl-4,6-dimethoxypyrimidine 113583-35-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-12

113583-35-0, 2-Methanesulfonyl-4,6-dimethoxypyrimidineRelated Search:

2-Amino-4,6-dimethylpyrimidine 4,6-Dimethoxy-2-(phenoxycarbonyl)aminopyrimidine (Trifluoromethoxy)benzene m-Anisyl alcohol Methoxyacetic acid Anisole Dimethyldimethoxysilane p-Anisidine 2,6-Dihydroxybenzoic acid 2-Mercapto-4,6-dimethoxypyrimidine 4,6-Dimethoxypyrimidine SULFACHLOROPYRIDAZINE Methanesulfonic acid 4,6-DIMETHOXY-2-(METHYLSULFONYL)PYRIMIDINE 2-METHANESULFONYL-PYRIMIDINE 4,6-Dimethoxy-2-methylthiopyrimidine 4,6-Dimethylpyrimidine-2-sulfonamide 2-Methylthio-4,6-pyrimidinedione

  • DMMSP
  • 4,6-DIMETHOXY-2-(METHYLSULFONYL)PYRIMIDINE
  • 4,6-DIMETHOXY-2-METHYL-SULFONYLPYRIMIDIME
  • 2-METHYLSULFONYL-4,6-DIMETHOXYPYRIMIDINE
  • 2-METHYLSULFONY-4,6-DIMETHOXYPYRIDINE
  • 2-METHANESULFONYL-4,6-DIMETHOXY-PYRIMIDINE
  • PYRIMIDINE, 4,6-DIMETHOXY-2-(METHYLSULFONYL)-
  • 2-Methylsulfony-4,5-Dimethoxypyridine
  • 4,6-DIMETHYL-2-(METHOXYSULFONYL)PYRIMIDINE , 97%
  • 4,6-dimethoxy-2-mesyl-pyrimidine
  • 2-methylsulfony-4,6-dimethoxypyrimidine
  • DIMETHOXY-2-METHANESULFONYLPYRIMIDINE
  • 4,6-DIMETHOXY-2-(METHYLSULFONYL)PYRIMIDINE 98+%
  • 4,6-Dimethoxy-2-(Methylsulphonyl)Pyrimidine
  • 4,6-DIMETHOXY-2-(METHYLSULFONYL)
  • 4,6-Dimethyloxide-2-methylsulfonylpyrimidine
  • 2-methylsulphonyl-4,6-dimethoxypyrimidine
  • 4,5-dimethoxy-2-methylsulfonylpyrimidine
  • 2-Methylsulfonyl-4,6-dimethoxypyrimidine,97%
  • 2-Methylsulfonyl-4,6
  • 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine,97%
  • 2-Methanesulfonyl-4
  • 2-Methylsulfonyl-4,6-dimethoxypyrimidine ,98%
  • 4,6-Dimethoxy-2-(methylsulphonyl)-1,3-diazine, 4,6-Dimethoxypyrimidin-2-yl methyl sulphone
  • 4,6- twoMethoxy -2-Methyl sulfonylpyriMidinyl
  • DiMethoxy-2-(Methylsulfonyl)pyriM
  • 21158
  • 4,6-Dimethoxy-2-(methylsulfonyl)pyrimidine&gt
  • MSDP
  • 2-Methylsulfonyl-4,6-dimethoxypyrimidine ISO 9001：2015 REACH
  • 2-Methylsulfonyl-4,6-dimethoxypyrimidin
  • 113583-35-0
  • 13583-35-0
  • C7H10N2O4S
  • D2933G1
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Building Blocks
  • Heterocycle-Pyrimidine series
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidine
  • Pyrimidines
  • bc0001